Lineage for Protein: Pyruvate decarboxylase

  1. Root: SCOP 1.63
  2. 235644Class c: Alpha and beta proteins (a/b) [51349] (117 folds)
  3. 242757Fold c.36: Thiamin diphosphate-binding fold (THDP-binding) [52517] (1 superfamily)
    3 layers: a/b/a; parallel beta-sheet of 6 strands, order 213465
  4. 242758Superfamily c.36.1: Thiamin diphosphate-binding fold (THDP-binding) [52518] (4 families) (S)
    both pyridine (Pyr)- and pyrophosphate (PP)-binding modules have this fold
    conserved core consists of two Pyr and two PP-modules and binds two coenzyme molecules
  5. 242759Family c.36.1.1: Pyruvate oxidase and decarboxylase THDP-binding domains [52519] (4 proteins)
    the N-terminal, Pyr module is separated from the C-terminal, PP module by an alpa/beta domain of Rossmann-like topology
  6. 242806Protein Pyruvate decarboxylase [52520] (3 species)

Species:

  1. 242807Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52522] (2 PDB entries)
    1. Domains for 1pvd:
      1. 242808Domain d1pvda2: 1pvd A:2-181 [31777]
        Other proteins in same PDB: d1pvda1, d1pvdb1
      2. 242809Domain d1pvda3: 1pvd A:361-556 [31778]
        Other proteins in same PDB: d1pvda1, d1pvdb1
      3. 242810Domain d1pvdb2: 1pvd B:2-181 [31779]
        Other proteins in same PDB: d1pvda1, d1pvdb1
      4. 242811Domain d1pvdb3: 1pvd B:361-556 [31780]
        Other proteins in same PDB: d1pvda1, d1pvdb1
        complexed with mg, tpp
    2. Domains for 1qpb:
      1. 242812Domain d1qpba2: 1qpb A:2-181 [31781]
        Other proteins in same PDB: d1qpba1, d1qpbb1
      2. 242813Domain d1qpba3: 1qpb A:361-556 [31782]
        Other proteins in same PDB: d1qpba1, d1qpbb1
      3. 242814Domain d1qpbb2: 1qpb B:2-181 [31783]
        Other proteins in same PDB: d1qpba1, d1qpbb1
      4. 242815Domain d1qpbb3: 1qpb B:361-556 [31784]
        Other proteins in same PDB: d1qpba1, d1qpbb1
  2. 242816Brewer's yeast (Saccharomyces), uvarum strain [TaxId:230603] [52521] (1 PDB entry)
  3. 242821Zymomonas mobilis [TaxId:542] [52523] (1 PDB entry)

More info for Protein Pyruvate decarboxylase from c.36.1.1: Pyruvate oxidase and decarboxylase THDP-binding domains

Timeline for Protein Pyruvate decarboxylase from c.36.1.1: Pyruvate oxidase and decarboxylase THDP-binding domains: