SCOPe 2.05: Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain

Lineage for Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (7 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain [52475] (8 proteins)
   N-terminal domain is Pyr module, and C-terminal domain is PP module of thiamin diphosphate-binding fold

Proteins:

1. Acetohydroxyacid synthase catalytic subunit [69463] (2 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [69464] (6 PDB entries)
      Uniprot P07342 84-687

   2. Species Thale cress (Arabidopsis thaliana), chloroplast [TaxId:3702] [142123] (6 PDB entries)
      Uniprot P17597 281-459

2. Benzoylformate decarboxylase [52482] (1 species)

   • Species Pseudomonas putida [TaxId:303] [52483] (41 PDB entries)
     Uniprot P20906

3. Carboxyethylarginine synthase [102290] (1 species)

   • Species Streptomyces clavuligerus [TaxId:1901] [102291] (6 PDB entries)

4. Catabolic acetolactate synthase [102288] (1 species)

   • Species Klebsiella pneumoniae [TaxId:573] [102289] (3 PDB entries)

5. Indole-3-pyruvate decarboxylase [89637] (1 species)

   • Species Enterobacter cloacae [TaxId:550] [89638] (1 PDB entry)

6. Oxalyl-CoA decarboxylase [142124] (1 species)

   • Species Oxalobacter formigenes [TaxId:847] [142125] (6 PDB entries)
     Uniprot P40149 195-369

7. Pyruvate decarboxylase [52478] (3 species)
   rudiment domain with a variant fold, lacks FAD-binding

   1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52480] (2 PDB entries)

   2. Species Brewer's yeast (Saccharomyces uvarum) [TaxId:230603] [52479] (1 PDB entry)

   3. Species Zymomonas mobilis [TaxId:542] [52481] (1 PDB entry)

8. Pyruvate oxidase [52476] (2 species)
   binds FAD

   1. Species Aerococcus viridans [TaxId:1377] [142122] (2 PDB entries)

   2. Species Lactobacillus plantarum [TaxId:1590] [52477] (8 PDB entries)

More info for Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain

Timeline for Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain:

• Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain first appeared (with stable ids) in SCOP 1.55
  
• Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain appears in SCOPe 2.04
  
• Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain appears in SCOPe 2.06
  
• Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain appears in the current release, SCOPe 2.08