SCOP 1.71: Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain

Lineage for Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain

1. Root: SCOP 1.71

2. Class c: Alpha and beta proteins (a/b) [51349] (134 folds)

3. Fold c.31: DHS-like NAD/FAD-binding domain [52466] (1 superfamily)
   3 layers: a/b/a; parallel beta-sheet of 6 strands, order 321456; Rossmann-like

4. Superfamily c.31.1: DHS-like NAD/FAD-binding domain [52467] (5 families)
   binds cofactor molecules in the opposite direction than classical Rossmann fold

5. Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain [52475] (7 proteins)
   N-terminal domain is Pyr module, and C-terminal domain is PP module of thiamin diphosphate-binding fold

Proteins:

1. Acetohydroxyacid synthase catalytic subunit [69463] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [69464] (6 PDB entries)

2. Benzoylformate decarboxylase [52482] (1 species)

   • Species Pseudomonas putida [TaxId:303] [52483] (5 PDB entries)

3. Carboxyethylarginine synthase [102290] (1 species)

   • Species Streptomyces clavuligerus [TaxId:1901] [102291] (3 PDB entries)

4. Catabolic acetolactate synthase [102288] (1 species)

   • Species Klebsiella pneumoniae [TaxId:573] [102289] (3 PDB entries)

5. Indole-3-pyruvate decarboxylase [89637] (1 species)

   • Species Enterobacter cloacae [TaxId:550] [89638] (1 PDB entry)

6. Pyruvate decarboxylase [52478] (3 species)
   rudiment domain with a variant fold, lacks FAD-binding

   1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [52480] (2 PDB entries)

   2. Species Brewer's yeast (Saccharomyces), uvarum strain [TaxId:230603] [52479] (1 PDB entry)

   3. Species Zymomonas mobilis [TaxId:542] [52481] (1 PDB entry)

7. Pyruvate oxidase [52476] (1 species)
   binds FAD

   • Species Lactobacillus plantarum [TaxId:1590] [52477] (2 PDB entries)

More info for Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain

Timeline for Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain:

• Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain first appeared (with stable ids) in SCOP 1.55
  
• Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain appears in SCOP 1.69
  
• Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain appears in SCOP 1.73
  
• Family c.31.1.3: Pyruvate oxidase and decarboxylase, middle domain appears in the current release, SCOPe 2.08