SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family c.23.16.2: DJ-1/PfpI

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2101600Fold c.23: Flavodoxin-like [52171] (15 superfamilies)
    3 layers, a/b/a; parallel beta-sheet of 5 strand, order 21345
  4. 2104318Superfamily c.23.16: Class I glutamine amidotransferase-like [52317] (10 families) (S)
    conserved positions of the oxyanion hole and catalytic nucleophile; different constituent families contain different additional structures
  5. 2104490Family c.23.16.2: DJ-1/PfpI [52325] (10 protein domains)
    contains a catalytic triad or dyad different from the class I GAT triad

Protein Domains:

  1. 2104491DJ-1 [89603] (1 species)
    RNA-binding protein regulatory subunit
  2. 2104554GK2698 ortholog [117481] (1 species)
  3. 2104557HSP31 (HchA; YedU) [89609] (1 species)
    contains a buried Cys-His-Asp triad within one subunit
  4. 2104572Hypothetical protein Atu0886 [142072] (1 species)
  5. 2104577Hypothetical protein Ydr533Cp [102253] (1 species)
    contains a buried Cys-His-Glu triad within one subunit
  6. 2104588Hypothetical protein YhbO [89601] (1 species)
  7. 2104592Intracellular protease [52326] (1 species)
  8. 2104597Protein ThiJ (YajL) [142070] (1 species)
  9. 2104600Putative sigma cross-reacting protein 27A (SCRP-27A, EllB) [89606] (1 species)
    involved in an early stage of isoprenoid biosynthesis; contains a Cys-Glu putative catalytic dyad
  10. 2104608automated matches [190995] (7 species)
    not a true protein
    1. 2104609Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [258813] (1 PDB entry)
    2. 2104611Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:559292] [189556] (1 PDB entry)
    3. 2104614Species Candida albicans [TaxId:237561] [226745] (1 PDB entry)
    4. 2104616Species Human (Homo sapiens) [TaxId:9606] [188709] (1 PDB entry)
    5. 2104618Species Thermococcus onnurineus [TaxId:523850] [189567] (1 PDB entry)
    6. 2279411Species Salmonella enterica [TaxId:90371] [322712] (1 PDB entry)
    7. 2284387Species Escherichia coli [TaxId:562] [327688] (1 PDB entry)

More info for Family c.23.16.2: DJ-1/PfpI

Timeline for Family c.23.16.2: DJ-1/PfpI: