SCOP 1.69: Family c.10.2.5: L domain

Lineage for Family c.10.2.5: L domain

1. Root: SCOP 1.69

2. Class c: Alpha and beta proteins (a/b) [51349] (136 folds)

3. Fold c.10: Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [52046] (3 superfamilies)
   2 curved layers, a/b; parallel beta-sheet; order 1234...N; there are sequence similarities between different superfamilies

4. Superfamily c.10.2: L domain-like [52058] (8 families)
   less regular structure consisting of variable repeats

5. Family c.10.2.5: L domain [52071] (4 proteins)
   this is a repeat family; one repeat unit is 1n8z C:42-66 found in domain

Proteins:

1. EGF receptor extracellular domain [82326] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [82327] (3 PDB entries)

2. Protooncoprotein Her2 extracellular domain [82328] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [82329] (2 PDB entries)

   2. Species Rat (Rattus norvegicus) [TaxId:10116] [82330] (1 PDB entry)

3. Receptor protein-tyrosine kinase Erbb-3 extracellular domain [75145] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [75146] (1 PDB entry)

4. Type 1 insulin-like growth factor receptor extracellular domain [52072] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [52073] (1 PDB entry)
     L1 and L2 domains

More info for Family c.10.2.5: L domain

Timeline for Family c.10.2.5: L domain:

• Family c.10.2.5: L domain first appeared (with stable ids) in SCOP 1.55, called Family c.10.2.5: L1 and L2 domains of the type 1 insulin-like growth factor receptor
  
• Family c.10.2.5: L domain appears in SCOP 1.67
  
• Family c.10.2.5: L domain appears in SCOP 1.71
  
• Family c.10.2.5: L domain appears in the current release, SCOPe 2.08