SCOP 1.63: Family c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain

Lineage for Family c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain

1. Root: SCOP 1.63

2. Class c: Alpha and beta proteins (a/b) [51349] (117 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (10 families)

5. Family c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain [51868] (10 proteins)
   the beta-sheet is extended to 8 strands, order 32145678; strands 7 & 8 are antiparallel to the rest
   C-terminal domains also show some similarity

Proteins:

1. 6-phosphogluconate dehydrogenase [51871] (2 species)

   1. Species Sheep (Ovis orientalis aries) [TaxId:9940] [51872] (5 PDB entries)

   2. Species Trypanosoma brucei [TaxId:5691] [51873] (1 PDB entry)

2. Acetohydroxy acid isomeroreductase, ketoacid reductoisomerase (KARI) [51869] (1 species)
   contains additional subdomain at the N-terminus, partly ordered

   • Species Spinach (Spinacia oleracea) [TaxId:3562] [51870] (2 PDB entries)

3. Coenzyme F420H2:NADP+ oxidoreductase (FNO) [69421] (1 species)
   lacks all but the first helix of the C-terminal all-alpha domain

   • Species Archaeon Archaeoglobus fulgidus [TaxId:2234] [69422] (2 PDB entries)

4. Conserved hypothetical protein MTH1747 [75113] (1 species)

   • Species Archaeon Methanobacterium thermoautotrophicum [TaxId:145262] [75114] (1 PDB entry)

5. Glycerol-3- phosphate dehydrogenase [51881] (1 species)

   • Species Trypanosome (Leishmania mexicana) [TaxId:5665] [51882] (5 PDB entries)

6. Ketopantoate reductase PanE [69419] (1 species)

   • Species Escherichia coli [TaxId:562] [69420] (1 PDB entry)

7. Mannitol 2-dehydrogenase [82301] (1 species)

   • Species Pseudomonas fluorescens [TaxId:294] [82302] (2 PDB entries)

8. N-(1-D-carboxylethyl)-L-norvaline dehydrogenase [51879] (1 species)

   • Species Arthrobacter, strain 1c [TaxId:1663] [51880] (1 PDB entry)

9. Short chain L-3-hydroxyacyl CoA dehydrogenase [51874] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [51875] (7 PDB entries)

   2. Species Pig (Sus scrofa) [TaxId:9823] [51876] (1 PDB entry)

10. UDP-glucose dehydrogenase (UDPGDH) [51877] (1 species)

    • Species Streptococcus pyogenes [TaxId:1314] [51878] (2 PDB entries)

More info for Family c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain

Timeline for Family c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain:

• Family c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain first appeared (with stable ids) in SCOP 1.55
  
• Family c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain appears in SCOP 1.61
  
• Family c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain appears in SCOP 1.65
  
• Family c.2.1.6: 6-phosphogluconate dehydrogenase-like, N-terminal domain appears in the current release, SCOPe 2.08