SCOP 1.65: Protein: Lactate dehydrogenase

Lineage for Protein: Lactate dehydrogenase

Root: SCOP 1.65
Class c: Alpha and beta proteins (a/b) [51349] (121 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (10 families)
Family c.2.1.5: LDH N-terminal domain-like [51848] (5 proteins)
Protein Lactate dehydrogenase [51859] (11 species)

Species:

Bacillus stearothermophilus [TaxId:1422] [51864] (3 PDB entries)
1. Domain for 1ldb:
  - Domain d1ldb_1: 1ldb 15-162 [30174]
    Other proteins in same PDB: d1ldb_2
    complexed with so4
2. Domains for 1ldn:
  1. Domain d1ldna1: 1ldn A:15-162 [30166]
    Other proteins in same PDB: d1ldna2, d1ldnb2, d1ldnc2, d1ldnd2, d1ldne2, d1ldnf2, d1ldng2, d1ldnh2
  2. Domain d1ldnb1: 1ldn B:15-162 [30167]
    Other proteins in same PDB: d1ldna2, d1ldnb2, d1ldnc2, d1ldnd2, d1ldne2, d1ldnf2, d1ldng2, d1ldnh2
  3. Domain d1ldnc1: 1ldn C:15-162 [30168]
    Other proteins in same PDB: d1ldna2, d1ldnb2, d1ldnc2, d1ldnd2, d1ldne2, d1ldnf2, d1ldng2, d1ldnh2
  4. Domain d1ldnd1: 1ldn D:15-162 [30169]
    Other proteins in same PDB: d1ldna2, d1ldnb2, d1ldnc2, d1ldnd2, d1ldne2, d1ldnf2, d1ldng2, d1ldnh2
  5. Domain d1ldne1: 1ldn E:15-162 [30170]
    Other proteins in same PDB: d1ldna2, d1ldnb2, d1ldnc2, d1ldnd2, d1ldne2, d1ldnf2, d1ldng2, d1ldnh2
  6. Domain d1ldnf1: 1ldn F:15-162 [30171]
    Other proteins in same PDB: d1ldna2, d1ldnb2, d1ldnc2, d1ldnd2, d1ldne2, d1ldnf2, d1ldng2, d1ldnh2
  7. Domain d1ldng1: 1ldn G:15-162 [30172]
    Other proteins in same PDB: d1ldna2, d1ldnb2, d1ldnc2, d1ldnd2, d1ldne2, d1ldnf2, d1ldng2, d1ldnh2
  8. Domain d1ldnh1: 1ldn H:15-162 [30173]
    Other proteins in same PDB: d1ldna2, d1ldnb2, d1ldnc2, d1ldnd2, d1ldne2, d1ldnf2, d1ldng2, d1ldnh2
    complexed with fbp, nad, oxm
3. Domain for 2ldb:
  - Domain d2ldb_1: 2ldb 15-162 [30175]
    Other proteins in same PDB: d2ldb_2
    complexed with fbp, nad, so4
Bifidobacterium longum, strain am101-2 [TaxId:216816] [51866] (2 PDB entries)
1. Domains for 1lld:
  1. Domain d1llda1: 1lld A:7-149 [30177]
    Other proteins in same PDB: d1llda2, d1lldb2
  2. Domain d1lldb1: 1lld B:7-149 [30178]
    Other proteins in same PDB: d1llda2, d1lldb2
    complexed with nad; mutant
2. Domains for 1lth:
  1. Domain d1lthr1: 1lth R:7-149 [30179]
    Other proteins in same PDB: d1lthr2, d1ltht2
  2. Domain d1ltht1: 1lth T:7-149 [30180]
    Other proteins in same PDB: d1lthr2, d1ltht2
    complexed with fbp, nad, oxm; mutant
Dogfish (Squalus acanthias) [TaxId:7797] [51862] (3 PDB entries)
1. Domain for 1ldm:
  - Domain d1ldm_1: 1ldm 1-160 [30160]
    Other proteins in same PDB: d1ldm_2
    complexed with nad, oxm
2. Domain for 6ldh:
  - Domain d6ldh_1: 6ldh 1-160 [30161]
    Other proteins in same PDB: d6ldh_2
    complexed with so4
3. Domain for 8ldh:
  - Domain d8ldh_1: 8ldh 1-160 [30162]
    Other proteins in same PDB: d8ldh_2
    complexed with cit
Human (Homo sapiens), heart isoform (H chain) [TaxId:9606] [63939] (1 PDB entry)
- Domains for 1i0z:
  1. Domain d1i0za1: 1i0z A:1-160 [61495]
    Other proteins in same PDB: d1i0za2, d1i0zb2
  2. Domain d1i0zb1: 1i0z B:1-160 [61497]
    Other proteins in same PDB: d1i0za2, d1i0zb2
    complexed with nai, oxm
Human (Homo sapiens), muscle isoform (M chain) [TaxId:9606] [63940] (1 PDB entry)
- Domains for 1i10:
  1. Domain d1i10a1: 1i10 A:1-159 [61499]
    Other proteins in same PDB: d1i10a2, d1i10b2, d1i10c2, d1i10d2, d1i10e2, d1i10f2, d1i10g2, d1i10h2
  2. Domain d1i10b1: 1i10 B:1-159 [61501]
    Other proteins in same PDB: d1i10a2, d1i10b2, d1i10c2, d1i10d2, d1i10e2, d1i10f2, d1i10g2, d1i10h2
  3. Domain d1i10c1: 1i10 C:1-159 [61503]
    Other proteins in same PDB: d1i10a2, d1i10b2, d1i10c2, d1i10d2, d1i10e2, d1i10f2, d1i10g2, d1i10h2
  4. Domain d1i10d1: 1i10 D:1-159 [61505]
    Other proteins in same PDB: d1i10a2, d1i10b2, d1i10c2, d1i10d2, d1i10e2, d1i10f2, d1i10g2, d1i10h2
  5. Domain d1i10e1: 1i10 E:1-159 [61507]
    Other proteins in same PDB: d1i10a2, d1i10b2, d1i10c2, d1i10d2, d1i10e2, d1i10f2, d1i10g2, d1i10h2
  6. Domain d1i10f1: 1i10 F:1-159 [61509]
    Other proteins in same PDB: d1i10a2, d1i10b2, d1i10c2, d1i10d2, d1i10e2, d1i10f2, d1i10g2, d1i10h2
  7. Domain d1i10g1: 1i10 G:1-159 [61511]
    Other proteins in same PDB: d1i10a2, d1i10b2, d1i10c2, d1i10d2, d1i10e2, d1i10f2, d1i10g2, d1i10h2
  8. Domain d1i10h1: 1i10 H:1-159 [61513]
    Other proteins in same PDB: d1i10a2, d1i10b2, d1i10c2, d1i10d2, d1i10e2, d1i10f2, d1i10g2, d1i10h2
    complexed with act, nai, oxm
Lactobacillus casei [TaxId:1582] [51865] (1 PDB entry)
- Domain for 1llc:
  - Domain d1llc_1: 1llc 13-164 [30176]
    Other proteins in same PDB: d1llc_2
    complexed with fbp, so4
Lactobacillus pentosus [TaxId:1589] [69418] (1 PDB entry)
- Domains for 1ez4:
  1. Domain d1ez4a1: 1ez4 A:16-162 [64917]
    Other proteins in same PDB: d1ez4a2, d1ez4b2, d1ez4c2, d1ez4d2
  2. Domain d1ez4b1: 1ez4 B:16-162 [64919]
    Other proteins in same PDB: d1ez4a2, d1ez4b2, d1ez4c2, d1ez4d2
  3. Domain d1ez4c1: 1ez4 C:16-162 [64921]
    Other proteins in same PDB: d1ez4a2, d1ez4b2, d1ez4c2, d1ez4d2
  4. Domain d1ez4d1: 1ez4 D:16-162 [64923]
    Other proteins in same PDB: d1ez4a2, d1ez4b2, d1ez4c2, d1ez4d2
    complexed with nad
Malaria parasite (Plasmodium falciparum) [TaxId:5833] [51863] (3 PDB entries)
1. Domain for 1ceq:
  - Domain d1ceqa1: 1ceq A:19-163 [30163]
    Other proteins in same PDB: d1ceqa2
2. Domain for 1cet:
  - Domain d1ceta1: 1cet A:18-163 [30164]
    Other proteins in same PDB: d1ceta2
    complexed with clq
3. Domain for 1ldg:
  - Domain d1ldg_1: 1ldg 18-163 [30165]
    Other proteins in same PDB: d1ldg_2
    complexed with nad, oxm
Mouse (Mus musculus) [TaxId:10090] [51861] (1 PDB entry)
- Domain for 2ldx:
  - Domain d2ldx_1: 2ldx 1-159 [30159]
    Other proteins in same PDB: d2ldx_2
Pig (Sus scrofa) [TaxId:9823] [51860] (3 PDB entries)
1. Domain for 5ldh:
  - Domain d5ldh_1: 5ldh 1-162 [30158]
    Other proteins in same PDB: d5ldh_2
    complexed with cit, nal
2. Domains for 9ldb:
  1. Domain d9ldba1: 9ldb A:1-162 [30156]
    Other proteins in same PDB: d9ldba2, d9ldbb2
  2. Domain d9ldbb1: 9ldb B:1-162 [30157]
    Other proteins in same PDB: d9ldba2, d9ldbb2
    complexed with nad, oxm, so4
3. Domains for 9ldt:
  1. Domain d9ldta1: 9ldt A:1-162 [30154]
    Other proteins in same PDB: d9ldta2, d9ldtb2
  2. Domain d9ldtb1: 9ldt B:1-162 [30155]
    Other proteins in same PDB: d9ldta2, d9ldtb2
    complexed with nad, oxm, so4
Thermotoga maritima [TaxId:243274] [51867] (1 PDB entry)
- Domain for 1a5z:
  - Domain d1a5z_1: 1a5z 22-163 [30181]
    Other proteins in same PDB: d1a5z_2
    complexed with cd, fbp, nad, oxm

More info for Protein Lactate dehydrogenase from c.2.1.5: LDH N-terminal domain-like

Timeline for Protein Lactate dehydrogenase from c.2.1.5: LDH N-terminal domain-like:

Protein Lactate dehydrogenase from c.2.1.5: LDH N-terminal domain-like first appeared (with stable ids) in SCOP 1.55, called Protein Lactate dehydrogenase from c.2.1.5: Lactate & malate dehydrogenases, N-terminal domain
Protein Lactate dehydrogenase from c.2.1.5: LDH N-terminal domain-like was called Protein Lactate dehydrogenase from c.2.1.5: Lactate & malate dehydrogenases, N-terminal domain in SCOP 1.63
Protein Lactate dehydrogenase from c.2.1.5: LDH N-terminal domain-like appears in SCOP 1.67
Protein Lactate dehydrogenase from c.2.1.5: LDH N-terminal domain-like appears in the current release, SCOPe 2.08