SCOP 1.63: Family c.2.1.5: Lactate & malate dehydrogenases, N-terminal domain

Lineage for Family c.2.1.5: Lactate & malate dehydrogenases, N-terminal domain

1. Root: SCOP 1.63

2. Class c: Alpha and beta proteins (a/b) [51349] (117 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (10 families)

5. Family c.2.1.5: Lactate & malate dehydrogenases, N-terminal domain [51848] (4 proteins)

Proteins:

1. L-2-hydroxyisocapronate dehydrogenase, L-HICDH [51857] (1 species)

   • Species Lactobacillus confusus [TaxId:1583] [51858] (1 PDB entry)

2. Lactate dehydrogenase [51859] (11 species)

   1. Species Bacillus stearothermophilus [TaxId:1422] [51864] (3 PDB entries)

   2. Species Bifidobacterium longum, strain am101-2 [TaxId:216816] [51866] (2 PDB entries)

   3. Species Dogfish (Squalus acanthias) [TaxId:7797] [51862] (3 PDB entries)

   4. Species Human (Homo sapiens), heart isoform (H chain) [TaxId:9606] [63939] (1 PDB entry)

   5. Species Human (Homo sapiens), muscle isoform (M chain) [TaxId:9606] [63940] (1 PDB entry)

   6. Species Lactobacillus casei [TaxId:1582] [51865] (1 PDB entry)

   7. Species Lactobacillus pentosus [TaxId:1589] [69418] (1 PDB entry)

   8. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [51863] (3 PDB entries)

   9. Species Mouse (Mus musculus) [TaxId:10090] [51861] (1 PDB entry)

   10. Species Pig (Sus scrofa) [TaxId:9823] [51860] (3 PDB entries)

   11. Species Thermotoga maritima [TaxId:243274] [51867] (1 PDB entry)

3. Malate dehydrogenase [51849] (11 species)

   1. Species Aquaspirillum arcticum [TaxId:87645] [51856] (3 PDB entries)

   2. Species Archaeon Haloarcula marismortui [TaxId:2238] [51855] (5 PDB entries)

   3. Species Chlorobium tepidum [TaxId:1097] [69416] (1 PDB entry)

   4. Species Chlorobium vibrioforme [TaxId:1098] [69417] (2 PDB entries)

   5. Species Chloroflexus aurantiacus [69415] (1 PDB entry)

   6. Species Escherichia coli [TaxId:562] [51853] (4 PDB entries)

   7. Species Flaveria bidentis, chloroplast [TaxId:4224] [51852] (1 PDB entry)

   8. Species Pig (Sus scrofa) [TaxId:9823] [51850] (3 PDB entries)

   9. Species Sorghum (Sorghum vulgare), chloroplast [TaxId:4558] [51851] (1 PDB entry)

   10. Species Thermus flavus [TaxId:274] [51854] (2 PDB entries)

   11. Species Thermus thermophilus [TaxId:274] [82300] (1 PDB entry)
       identical sequence to that from the Thermus flavus enzyme

4. MJ0490, lactate/malate dehydrogenase [63941] (1 species)

   • Species Archaeon Methanococcus jannaschii [TaxId:2190] [63942] (2 PDB entries)

More info for Family c.2.1.5: Lactate & malate dehydrogenases, N-terminal domain

Timeline for Family c.2.1.5: Lactate & malate dehydrogenases, N-terminal domain:

• Family c.2.1.5: Lactate & malate dehydrogenases, N-terminal domain first appeared (with stable ids) in SCOP 1.55
  
• Family c.2.1.5: Lactate & malate dehydrogenases, N-terminal domain appears in SCOP 1.61
  
• Family c.2.1.5: Lactate & malate dehydrogenases, N-terminal domain is called Family c.2.1.5: LDH N-terminal domain-like in SCOP 1.65
  
• Family c.2.1.5: Lactate & malate dehydrogenases, N-terminal domain appears in the current release, SCOPe 2.08, called Family c.2.1.5: LDH N-terminal domain-like