SCOP 1.63: Protein: Alcohol dehydrogenase

Lineage for Protein: Alcohol dehydrogenase

Root: SCOP 1.63
Class c: Alpha and beta proteins (a/b) [51349] (117 folds)

Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
The nucleotide-binding modes of this and the next two folds/superfamilies are similar

Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (10 families)
Family c.2.1.1: Alcohol/glucose dehydrogenases, C-terminal domain [51736] (6 proteins)
N-terminal all-beta domain defines family
Protein Alcohol dehydrogenase [51737] (5 species)

Species:

Archaeon Sulfolobus solfataricus [TaxId:2287] [82286] (1 PDB entry)
- Domain for 1jvb:
  - Domain d1jvba2: 1jvb A:154-297 [77182]
    Other proteins in same PDB: d1jvba1
    complexed with mse, zn
Cod (Gadus callarias) [TaxId:8053] [51741] (1 PDB entry)
- Domains for 1cdo:
  1. Domain d1cdoa2: 1cdo A:176-324 [29763]
    Other proteins in same PDB: d1cdoa1, d1cdob1
  2. Domain d1cdob2: 1cdo B:176-324 [29764]
    Other proteins in same PDB: d1cdoa1, d1cdob1
    complexed with nad, zn
Horse (Equus caballus) [TaxId:9796] [51738] (30 PDB entries)
1. Domains for 1a71:
  1. Domain d1a71a2: 1a71 A:175-324 [29689]
    Other proteins in same PDB: d1a71a1, d1a71b1
  2. Domain d1a71b2: 1a71 B:175-324 [29690]
    Other proteins in same PDB: d1a71a1, d1a71b1
    complexed with etf, nad, zn; mutant
2. Domain for 1a72:
  - Domain d1a72_2: 1a72 175-324 [29715]
    Other proteins in same PDB: d1a72_1
    complexed with pad, zn; mutant
3. Domains for 1adb:
  1. Domain d1adba2: 1adb A:175-324 [29699]
    Other proteins in same PDB: d1adba1, d1adbb1
  2. Domain d1adbb2: 1adb B:175-324 [29700]
    Other proteins in same PDB: d1adba1, d1adbb1
    complexed with cnd, eoh, zn
4. Domains for 1adc:
  1. Domain d1adca2: 1adc A:175-324 [29718]
    Other proteins in same PDB: d1adca1, d1adcb1
  2. Domain d1adcb2: 1adc B:175-324 [29719]
    Other proteins in same PDB: d1adca1, d1adcb1
    complexed with eoh, pad, zn
5. Domain for 1adf:
  - Domain d1adf_2: 1adf 175-324 [29717]
    Other proteins in same PDB: d1adf_1
    complexed with tad, zn
6. Domain for 1adg:
  - Domain d1adg_2: 1adg 175-324 [29716]
    Other proteins in same PDB: d1adg_1
    complexed with sad, zn
7. Domains for 1axe:
  1. Domain d1axea2: 1axe A:175-324 [29697]
    Other proteins in same PDB: d1axea1, d1axeb1
  2. Domain d1axeb2: 1axe B:175-324 [29698]
    Other proteins in same PDB: d1axea1, d1axeb1
    complexed with etf, nad, zn; mutant
8. Domains for 1axg:
  1. Domain d1axga2: 1axg A:175-324 [29707]
    Other proteins in same PDB: d1axga1, d1axgb1, d1axgc1, d1axgd1
  2. Domain d1axgb2: 1axg B:175-324 [29708]
    Other proteins in same PDB: d1axga1, d1axgb1, d1axgc1, d1axgd1
  3. Domain d1axgc2: 1axg C:175-324 [29709]
    Other proteins in same PDB: d1axga1, d1axgb1, d1axgc1, d1axgd1
  4. Domain d1axgd2: 1axg D:175-324 [29710]
    Other proteins in same PDB: d1axga1, d1axgb1, d1axgc1, d1axgd1
    complexed with etf, nad, zn; mutant
9. Domains for 1bto:
  1. Domain d1btoa2: 1bto A:175-324 [29693]
    Other proteins in same PDB: d1btoa1, d1btob1, d1btoc1, d1btod1
  2. Domain d1btob2: 1bto B:175-324 [29694]
    Other proteins in same PDB: d1btoa1, d1btob1, d1btoc1, d1btod1
  3. Domain d1btoc2: 1bto C:175-324 [29695]
    Other proteins in same PDB: d1btoa1, d1btob1, d1btoc1, d1btod1
  4. Domain d1btod2: 1bto D:175-324 [29696]
    Other proteins in same PDB: d1btoa1, d1btob1, d1btoc1, d1btod1
    complexed with nad, ssb, zn
10. Domains for 1ee2:
  1. Domain d1ee2a2: 1ee2 A:174-323 [29679]
    Other proteins in same PDB: d1ee2a1, d1ee2b1
  2. Domain d1ee2b2: 1ee2 B:174-323 [29680]
    Other proteins in same PDB: d1ee2a1, d1ee2b1
    steroid-active isozyme
    complexed with chd, nad, zn
11. Domains for 1het:
  1. Domain d1heta2: 1het A:175-324 [60976]
    Other proteins in same PDB: d1heta1, d1hetb1
  2. Domain d1hetb2: 1het B:175-324 [60978]
    Other proteins in same PDB: d1heta1, d1hetb1
    complexed with mpd, nad, zn
12. Domains for 1heu:
  1. Domain d1heua2: 1heu A:175-324 [60980]
    Other proteins in same PDB: d1heua1, d1heub1
  2. Domain d1heub2: 1heu B:175-324 [60982]
    Other proteins in same PDB: d1heua1, d1heub1
    complexed with cd, mpd, nad
13. Domains for 1hf3:
  1. Domain d1hf3a2: 1hf3 A:175-324 [61001]
    Other proteins in same PDB: d1hf3a1, d1hf3b1
  2. Domain d1hf3b2: 1hf3 B:175-324 [61003]
    Other proteins in same PDB: d1hf3a1, d1hf3b1
    complexed with cd, mpd, nad
14. Domains for 1hld:
  1. Domain d1hlda2: 1hld A:175-324 [29691]
    Other proteins in same PDB: d1hlda1, d1hldb1
  2. Domain d1hldb2: 1hld B:175-324 [29692]
    Other proteins in same PDB: d1hlda1, d1hldb1
    complexed with brb, nad, pfb, zn
15. Domains for 1ju9:
  1. Domain d1ju9a2: 1ju9 A:175-324 [63294]
    Other proteins in same PDB: d1ju9a1, d1ju9b1
  2. Domain d1ju9b2: 1ju9 B:175-324 [63296]
    Other proteins in same PDB: d1ju9a1, d1ju9b1
    complexed with nad, zn; mutant
16. Domains for 1lde:
  1. Domain d1ldea2: 1lde A:175-324 [29702]
    Other proteins in same PDB: d1ldea1, d1ldeb1, d1ldec1, d1lded1
  2. Domain d1ldeb2: 1lde B:175-324 [29703]
    Other proteins in same PDB: d1ldea1, d1ldeb1, d1ldec1, d1lded1
  3. Domain d1ldec2: 1lde C:175-324 [29704]
    Other proteins in same PDB: d1ldea1, d1ldeb1, d1ldec1, d1lded1
  4. Domain d1lded2: 1lde D:175-324 [29705]
    Other proteins in same PDB: d1ldea1, d1ldeb1, d1ldec1, d1lded1
    complexed with fpi, nad, zn
17. Domains for 1ldy:
  1. Domain d1ldya2: 1ldy A:175-324 [29711]
    Other proteins in same PDB: d1ldya1, d1ldyb1, d1ldyc1, d1ldyd1
  2. Domain d1ldyb2: 1ldy B:175-324 [29712]
    Other proteins in same PDB: d1ldya1, d1ldyb1, d1ldyc1, d1ldyd1
  3. Domain d1ldyc2: 1ldy C:175-324 [29713]
    Other proteins in same PDB: d1ldya1, d1ldyb1, d1ldyc1, d1ldyd1
  4. Domain d1ldyd2: 1ldy D:175-324 [29714]
    Other proteins in same PDB: d1ldya1, d1ldyb1, d1ldyc1, d1ldyd1
    complexed with cxf, nad, zn
18. Domains for 1mg0:
  1. Domain d1mg0a2: 1mg0 A:175-324 [79052]
    Other proteins in same PDB: d1mg0a1, d1mg0b1, d1mg0c1, d1mg0d1
  2. Domain d1mg0b2: 1mg0 B:175-324 [79054]
    Other proteins in same PDB: d1mg0a1, d1mg0b1, d1mg0c1, d1mg0d1
  3. Domain d1mg0c2: 1mg0 C:175-324 [79056]
    Other proteins in same PDB: d1mg0a1, d1mg0b1, d1mg0c1, d1mg0d1
  4. Domain d1mg0d2: 1mg0 D:175-324 [79058]
    Other proteins in same PDB: d1mg0a1, d1mg0b1, d1mg0c1, d1mg0d1
    complexed with dfb, nad, zn
19. Domains for 1mgo:
  1. Domain d1mgoa2: 1mgo A:175-324 [79095]
    Other proteins in same PDB: d1mgoa1, d1mgob1
  2. Domain d1mgob2: 1mgo B:175-324 [79097]
    Other proteins in same PDB: d1mgoa1, d1mgob1
    complexed with mpd, nad, pfb, zn; mutant
20. Domains for 1n8k:
  1. Domain d1n8ka2: 1n8k A:175-324 [80299]
    Other proteins in same PDB: d1n8ka1, d1n8kb1
  2. Domain d1n8kb2: 1n8k B:175-324 [80301]
    Other proteins in same PDB: d1n8ka1, d1n8kb1
    complexed with mpd, naj, pzo, zn; mutant
21. Domains for 1n92:
  1. Domain d1n92a2: 1n92 A:175-324 [80328]
    Other proteins in same PDB: d1n92a1, d1n92b1
  2. Domain d1n92b2: 1n92 B:175-324 [80330]
    Other proteins in same PDB: d1n92a1, d1n92b1
    complexed with mpd, naj, pyz, zn
22. Domain for 1qlh:
  - Domain d1qlha2: 1qlh A:175-324 [29701]
    Other proteins in same PDB: d1qlha1
23. Domain for 1qlj:
  - Domain d1qlja2: 1qlj A:175-324 [29720]
    Other proteins in same PDB: d1qlja1
24. Domains for 2ohx:
  1. Domain d2ohxa2: 2ohx A:175-324 [29685]
    Other proteins in same PDB: d2ohxa1, d2ohxb1
  2. Domain d2ohxb2: 2ohx B:175-324 [29686]
    Other proteins in same PDB: d2ohxa1, d2ohxb1
    complexed with dms, nad, zn
25. Domains for 2oxi:
  1. Domain d2oxia2: 2oxi A:175-324 [29687]
    Other proteins in same PDB: d2oxia1, d2oxib1
  2. Domain d2oxib2: 2oxi B:175-324 [29688]
    Other proteins in same PDB: d2oxia1, d2oxib1
    complexed with cu, dms, nad, zn
26. Domains for 3bto:
  1. Domain d3btoa2: 3bto A:175-324 [29681]
    Other proteins in same PDB: d3btoa1, d3btob1, d3btoc1, d3btod1
  2. Domain d3btob2: 3bto B:175-324 [29682]
    Other proteins in same PDB: d3btoa1, d3btob1, d3btoc1, d3btod1
  3. Domain d3btoc2: 3bto C:175-324 [29683]
    Other proteins in same PDB: d3btoa1, d3btob1, d3btoc1, d3btod1
  4. Domain d3btod2: 3bto D:175-324 [29684]
    Other proteins in same PDB: d3btoa1, d3btob1, d3btoc1, d3btod1
    complexed with nad, ssb, zn
27. Domain for 5adh:
  - Domain d5adh_2: 5adh 175-324 [29721]
    Other proteins in same PDB: d5adh_1
    complexed with adr, mpd, zn
28. Domains for 6adh:
  1. Domain d6adha2: 6adh A:175-324 [29722]
    Other proteins in same PDB: d6adha1, d6adhb1
  2. Domain d6adhb2: 6adh B:175-324 [29723]
    Other proteins in same PDB: d6adha1, d6adhb1
    complexed with dms, nad, zn
29. Domain for 7adh:
  - Domain d7adh_2: 7adh 175-324 [29724]
    Other proteins in same PDB: d7adh_1
    complexed with zn
30. Domain for 8adh:
  - Domain d8adh_2: 8adh 175-324 [29706]
    Other proteins in same PDB: d8adh_1
    complexed with zn
Human (Homo sapiens), different isozymes [TaxId:9606] [51739] (17 PDB entries)
1. Domains for 1agn:
  1. Domain d1agna2: 1agn A:175-324 [29753]
    Other proteins in same PDB: d1agna1, d1agnb1, d1agnc1, d1agnd1
  2. Domain d1agnb2: 1agn B:175-324 [29754]
    Other proteins in same PDB: d1agna1, d1agnb1, d1agnc1, d1agnd1
  3. Domain d1agnc2: 1agn C:175-324 [29755]
    Other proteins in same PDB: d1agna1, d1agnb1, d1agnc1, d1agnd1
  4. Domain d1agnd2: 1agn D:175-324 [29756]
    Other proteins in same PDB: d1agna1, d1agnb1, d1agnc1, d1agnd1
    sigma isozyme
    complexed with act, nad, zn
2. Domains for 1d1s:
  1. Domain d1d1sa2: 1d1s A:175-324 [29743]
    Other proteins in same PDB: d1d1sa1, d1d1sb1, d1d1sc1, d1d1sd1
  2. Domain d1d1sb2: 1d1s B:175-324 [29744]
    Other proteins in same PDB: d1d1sa1, d1d1sb1, d1d1sc1, d1d1sd1
  3. Domain d1d1sc2: 1d1s C:175-324 [29745]
    Other proteins in same PDB: d1d1sa1, d1d1sb1, d1d1sc1, d1d1sd1
  4. Domain d1d1sd2: 1d1s D:175-324 [29746]
    Other proteins in same PDB: d1d1sa1, d1d1sb1, d1d1sc1, d1d1sd1
    sigma isozyme
    complexed with act, cac, nad, zn
3. Domains for 1d1t:
  1. Domain d1d1ta2: 1d1t A:175-324 [29735]
    Other proteins in same PDB: d1d1ta1, d1d1tb1, d1d1tc1, d1d1td1
  2. Domain d1d1tb2: 1d1t B:175-324 [29736]
    Other proteins in same PDB: d1d1ta1, d1d1tb1, d1d1tc1, d1d1td1
  3. Domain d1d1tc2: 1d1t C:175-324 [29737]
    Other proteins in same PDB: d1d1ta1, d1d1tb1, d1d1tc1, d1d1td1
  4. Domain d1d1td2: 1d1t D:175-324 [29738]
    Other proteins in same PDB: d1d1ta1, d1d1tb1, d1d1tc1, d1d1td1
    sigma isozyme
    complexed with act, cac, nad, zn; mutant
4. Domains for 1deh:
  1. Domain d1deha2: 1deh A:175-324 [29729]
    Other proteins in same PDB: d1deha1, d1dehb1
  2. Domain d1dehb2: 1deh B:175-324 [29730]
    Other proteins in same PDB: d1deha1, d1dehb1
    complexed with cl, nad, pyz, zn
5. Domains for 1hdx:
  1. Domain d1hdxa2: 1hdx A:175-324 [29733]
    Other proteins in same PDB: d1hdxa1, d1hdxb1
  2. Domain d1hdxb2: 1hdx B:175-324 [29734]
    Other proteins in same PDB: d1hdxa1, d1hdxb1
    complexed with cl, cxl, nad, zn
6. Domains for 1hdy:
  1. Domain d1hdya2: 1hdy A:175-324 [29739]
    Other proteins in same PDB: d1hdya1, d1hdyb1
  2. Domain d1hdyb2: 1hdy B:175-324 [29740]
    Other proteins in same PDB: d1hdya1, d1hdyb1
    complexed with cl, nad, pyz, zn
7. Domains for 1hdz:
  1. Domain d1hdza2: 1hdz A:175-324 [29741]
    Other proteins in same PDB: d1hdza1, d1hdzb1
  2. Domain d1hdzb2: 1hdz B:175-324 [29742]
    Other proteins in same PDB: d1hdza1, d1hdzb1
    complexed with cl, nad, zn; mutant
8. Domains for 1hso:
  1. Domain d1hsoa2: 1hso A:175-324 [29747]
    Other proteins in same PDB: d1hsoa1, d1hsob1
  2. Domain d1hsob2: 1hso B:175-324 [29748]
    Other proteins in same PDB: d1hsoa1, d1hsob1
    alpha isozyme
    complexed with nad, pyz, zn
9. Domains for 1hsz:
  1. Domain d1hsza2: 1hsz A:175-324 [29727]
    Other proteins in same PDB: d1hsza1, d1hszb1
  2. Domain d1hszb2: 1hsz B:175-324 [29728]
    Other proteins in same PDB: d1hsza1, d1hszb1
    beta-1 isozyme
    complexed with nad, po4, zn
10. Domains for 1ht0:
  1. Domain d1ht0a2: 1ht0 A:175-324 [29725]
    Other proteins in same PDB: d1ht0a1, d1ht0b1
  2. Domain d1ht0b2: 1ht0 B:175-324 [29726]
    Other proteins in same PDB: d1ht0a1, d1ht0b1
    gamma-2 isozyme
    complexed with nad, zn; mutant
11. Domains for 1htb:
  1. Domain d1htba2: 1htb A:175-324 [29731]
    Other proteins in same PDB: d1htba1, d1htbb1
  2. Domain d1htbb2: 1htb B:175-324 [29732]
    Other proteins in same PDB: d1htba1, d1htbb1
    complexed with cl, nad, pyz, zn
12. Domains for 1m6h:
  1. Domain d1m6ha2: 1m6h A:175-324 [74530]
    Other proteins in same PDB: d1m6ha1, d1m6hb1
  2. Domain d1m6hb2: 1m6h B:175-324 [74532]
    Other proteins in same PDB: d1m6ha1, d1m6hb1
    glutathione-dependent formaldehyde dehydrogenase
    complexed with k, po4, zn
13. Domains for 1m6w:
  1. Domain d1m6wa2: 1m6w A:175-324 [74569]
    Other proteins in same PDB: d1m6wa1, d1m6wb1
  2. Domain d1m6wb2: 1m6w B:175-324 [74571]
    Other proteins in same PDB: d1m6wa1, d1m6wb1
    glutathione-dependent formaldehyde dehydrogenase
    complexed with 12h, k, po4, zn
14. Domains for 1ma0:
  1. Domain d1ma0a2: 1ma0 A:175-324 [74606]
    Other proteins in same PDB: d1ma0a1, d1ma0b1
  2. Domain d1ma0b2: 1ma0 B:175-324 [74608]
    Other proteins in same PDB: d1ma0a1, d1ma0b1
    glutathione-dependent formaldehyde dehydrogenase
    complexed with k, lau, nad, po4, zn
15. Domains for 1mp0:
  1. Domain d1mp0a2: 1mp0 A:175-324 [79371]
    Other proteins in same PDB: d1mp0a1, d1mp0b1
  2. Domain d1mp0b2: 1mp0 B:175-324 [79373]
    Other proteins in same PDB: d1mp0a1, d1mp0b1
    glutathione-dependent formaldehyde dehydrogenase
    complexed with k, nad, po4, zn
16. Domains for 1teh:
  1. Domain d1teha2: 1teh A:175-324 [29749]
    Other proteins in same PDB: d1teha1, d1tehb1
  2. Domain d1tehb2: 1teh B:175-324 [29750]
    Other proteins in same PDB: d1teha1, d1tehb1
    glutathione-dependent formaldehyde dehydrogenase
    complexed with nad, zn
17. Domains for 3hud:
  1. Domain d3huda2: 3hud A:175-324 [29751]
    Other proteins in same PDB: d3huda1, d3hudb1
  2. Domain d3hudb2: 3hud B:175-324 [29752]
    Other proteins in same PDB: d3huda1, d3hudb1
    complexed with nad, zn
Mouse (Mus musculus), class II [TaxId:10090] [51740] (3 PDB entries)
1. Domains for 1e3e:
  1. Domain d1e3ea2: 1e3e A:175-324 [29759]
    Other proteins in same PDB: d1e3ea1, d1e3eb1
  2. Domain d1e3eb2: 1e3e B:175-324 [29760]
    Other proteins in same PDB: d1e3ea1, d1e3eb1
    complexed with nad, zn
2. Domains for 1e3i:
  1. Domain d1e3ia2: 1e3i A:175-324 [29757]
    Other proteins in same PDB: d1e3ia1, d1e3ib1
  2. Domain d1e3ib2: 1e3i B:175-324 [29758]
    Other proteins in same PDB: d1e3ia1, d1e3ib1
    complexed with cxf, nad, zn
3. Domains for 1e3l:
  1. Domain d1e3la2: 1e3l A:175-324 [29761]
    Other proteins in same PDB: d1e3la1, d1e3lb1
  2. Domain d1e3lb2: 1e3l B:175-324 [29762]
    Other proteins in same PDB: d1e3la1, d1e3lb1
    complexed with nad, zn; mutant

More info for Protein Alcohol dehydrogenase from c.2.1.1: Alcohol/glucose dehydrogenases, C-terminal domain

Timeline for Protein Alcohol dehydrogenase from c.2.1.1: Alcohol/glucose dehydrogenases, C-terminal domain:

Protein Alcohol dehydrogenase from c.2.1.1: Alcohol/glucose dehydrogenases, C-terminal domain first appeared (with stable ids) in SCOP 1.55
Protein Alcohol dehydrogenase from c.2.1.1: Alcohol/glucose dehydrogenases, C-terminal domain appears in SCOP 1.61
Protein Alcohol dehydrogenase from c.2.1.1: Alcohol/glucose dehydrogenases, C-terminal domain is called Protein Alcohol dehydrogenase from c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain in SCOP 1.65
Protein Alcohol dehydrogenase from c.2.1.1: Alcohol/glucose dehydrogenases, C-terminal domain appears in the current release, SCOPe 2.08, called Protein Alcohol dehydrogenase from c.2.1.1: Alcohol dehydrogenase-like, C-terminal domain