SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family c.1.23.1: Methylenetetrahydrofolate reductase

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2078560Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 2089931Superfamily c.1.23: FAD-linked oxidoreductase [51730] (2 families) (S)
    distinct cofactor-binding mode from both FMN- and NAD(P)-linked TIM-barrel oxidoreductases; families are related by a circular permutation
  5. 2089932Family c.1.23.1: Methylenetetrahydrofolate reductase [51731] (2 protein domains)
    automatically mapped to Pfam PF02219

Protein Domains:

  1. 2089933Methylenetetrahydrofolate reductase [51732] (2 species)
    1. 2089934Species Escherichia coli [TaxId:562] [51733] (7 PDB entries)
    2. 2089956Species Thermus thermophilus [TaxId:274] [102106] (1 PDB entry)
  2. 2089958automated matches [193645] (3 species)
    not a true protein
    1. 2089959Species Escherichia coli K-12 [TaxId:83333] [225710] (2 PDB entries)
    2. 2089966Species Thermus thermophilus HB8 [TaxId:300852] [193648] (2 PDB entries)
    3. 2286894Species Haemophilus influenzae [TaxId:71421] [330195] (1 PDB entry)

More info for Family c.1.23.1: Methylenetetrahydrofolate reductase

Timeline for Family c.1.23.1: Methylenetetrahydrofolate reductase: