SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2078560Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 2085156Superfamily c.1.10: Aldolase [51569] (9 families) (S)
    Common fold covers whole protein structure
  5. 2086002Family c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) [51594] (2 protein domains)
    hybrid of classes I and II aldolase
    automatically mapped to Pfam PF00490

Protein Domains:

  1. 20860035-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase) [51595] (5 species)
    1. 2086004Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [51596] (12 PDB entries)
    2. 2086017Species Escherichia coli [TaxId:562] [51598] (4 PDB entries)
    3. 2086025Species Human (Homo sapiens) [TaxId:9606] [63921] (4 PDB entries)
    4. 2086030Species Prosthecochloris vibrioformis [TaxId:1098] [110362] (2 PDB entries)
      Uniprot Q59334
    5. 2086035Species Pseudomonas aeruginosa [TaxId:287] [51597] (2 PDB entries)
  2. 2086040automated matches [190088] (5 species)
    not a true protein
    1. 2086041Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [186810] (1 PDB entry)
    2. 2086043Species Pseudomonas aeruginosa [TaxId:287] [187506] (8 PDB entries)
    3. 2086059Species Pseudomonas aeruginosa, PA01 [TaxId:208964] [188066] (6 PDB entries)
    4. 2271765Species Escherichia coli [TaxId:83333] [315066] (1 PDB entry)
    5. 2283730Species Escherichia coli [TaxId:562] [327031] (1 PDB entry)

More info for Family c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase)

Timeline for Family c.1.10.3: 5-aminolaevulinate dehydratase, ALAD (porphobilinogen synthase):