SCOP 1.75: Family c.1.10.1: Class I aldolase

Lineage for Family c.1.10.1: Class I aldolase

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.10: Aldolase [51569] (8 families)
   Common fold covers whole protein structure

5. Family c.1.10.1: Class I aldolase [51570] (12 proteins)
   the catalytic lysine forms schiff-base intermediate with substrate
   possible link between the aldolase superfamily and the phosphate-binding beta/alpha barrels

Proteins:

1. 2-keto-3-deoxy gluconate aldolase Eda [110360] (1 species)

   • Species Sulfolobus solfataricus [TaxId:2287] [110361] (4 PDB entries)
     Uniprot Q97U28

2. Archaeal fructose 1,6-bisphosphate aldolase [102088] (1 species)

   • Species Archaeon Thermoproteus tenax [TaxId:2271] [102089] (5 PDB entries)

3. Decameric fructose-6-phosphate aldolase/transaldolase [75085] (3 species)
   forms helix-swapped pentamers

   1. Species Escherichia coli [TaxId:562] [75086] (1 PDB entry)

   2. Species Thermotoga maritima [TaxId:2336] [117379] (1 PDB entry)
      Uniprot Q9WYD1

   3. Species Thermus thermophilus [TaxId:274] [141836] (1 PDB entry)
      Uniprot Q5SJE8 1-211
      clear orthologue of the E.coli protein; annotated as transaldolase in UniProt

4. Deoxyribose-phosphate aldolase DeoC [69394] (6 species)

   1. Species Aquifex aeolicus [TaxId:63363] [82271] (1 PDB entry)

   2. Species Archaeon Aeropyrum pernix [TaxId:56636] [89493] (1 PDB entry)

   3. Species Archaeon Pyrobaculum aerophilum [TaxId:13773] [141830] (1 PDB entry)
      Uniprot Q8ZXK7 1-226

   4. Species Escherichia coli [TaxId:562] [69395] (4 PDB entries)
      Uniprot P00882

   5. Species Thermotoga maritima [TaxId:2336] [82270] (1 PDB entry)
      TM1559

   6. Species Thermus thermophilus [TaxId:274] [89492] (2 PDB entries)

5. Dihydrodipicolinate synthase [51574] (4 species)

   1. Species Bacillus anthracis [TaxId:1392] [141832] (2 PDB entries)
      Uniprot Q81WN7 1-292

   2. Species Escherichia coli [TaxId:562] [51575] (9 PDB entries)

   3. Species Mycobacterium tuberculosis [TaxId:1773] [141831] (1 PDB entry)
      Uniprot P63945 5-300

   4. Species Thermotoga maritima [TaxId:2336] [102090] (1 PDB entry)

6. Fructose-1,6-bisphosphate aldolase [51576] (10 species)

   1. Species Drosophila melanogaster [TaxId:7227] [51579] (1 PDB entry)

   2. Species Human (Homo sapiens), brain isozyme [TaxId:9606] [141834] (1 PDB entry)
      Uniprot P09972 2-343

   3. Species Human (Homo sapiens), liver isozyme [TaxId:9606] [51578] (3 PDB entries)

   4. Species Human (Homo sapiens), muscle isozyme [TaxId:9606] [51577] (3 PDB entries)

   5. Species Plasmodium falciparum [TaxId:5833] [51581] (1 PDB entry)

   6. Species Plasmodium yoelii yoelii [TaxId:73239] [141833] (1 PDB entry)
      Uniprot Q7RMC9 3-258

   7. Species Rabbit (Oryctolagus cuniculus), liver isozyme [TaxId:9986] [63920] (1 PDB entry)

   8. Species Rabbit (Oryctolagus cuniculus), muscle isozyme [TaxId:9986] [51580] (15 PDB entries)

   9. Species Trypanosome (Leishmania mexicana) [TaxId:5665] [51582] (4 PDB entries)

   10. Species Trypanosome (Trypanosoma brucei) [TaxId:5691] [51583] (1 PDB entry)

7. Hypothetical protein HI0047 [102092] (1 species)
   putative KHG/KDPG aldolase

   • Species Haemophilus influenzae [TaxId:727] [102093] (1 PDB entry)

8. KDPG aldolase [51584] (3 species)

   1. Species Escherichia coli [TaxId:562] [51585] (7 PDB entries)

   2. Species Pseudomonas putida [TaxId:303] [102091] (1 PDB entry)

   3. Species Thermotoga maritima [TaxId:2336] [110357] (2 PDB entries)
      Uniprot Q9WXS1

9. N-acetylneuraminate lyase [51571] (2 species)

   1. Species Escherichia coli [TaxId:562] [51572] (4 PDB entries)

   2. Species Haemophilus influenzae [TaxId:727] [51573] (6 PDB entries)

10. Putative aldolase YihT [110358] (1 species)

    • Species Salmonella typhimurium [TaxId:90371] [110359] (1 PDB entry)
      Uniprot Q9L7R9

11. Transaldolase [51588] (3 species)
    probably related to class I aldolases by a circular permutation

    1. Species Escherichia coli [TaxId:562] [51589] (7 PDB entries)

    2. Species Human (Homo sapiens) [TaxId:9606] [51590] (1 PDB entry)

    3. Species Mouse (Mus musculus) [TaxId:10090] [141835] (2 PDB entries)
       Uniprot Q93092 13-331

12. Type I 3-dehydroquinate dehydratase [51586] (2 species)

    1. Species Salmonella typhi [TaxId:90370] [51587] (3 PDB entries)

    2. Species Staphylococcus aureus [TaxId:1280] [117378] (2 PDB entries)
       Uniprot Q6GII7

More info for Family c.1.10.1: Class I aldolase

Timeline for Family c.1.10.1: Class I aldolase:

• Family c.1.10.1: Class I aldolase first appeared (with stable ids) in SCOP 1.55
  
• Family c.1.10.1: Class I aldolase appears in SCOP 1.73
  
• Family c.1.10.1: Class I aldolase appears in SCOPe 2.01
  
• Family c.1.10.1: Class I aldolase appears in the current release, SCOPe 2.08