SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family c.1.8.4: Family 1 of glycosyl hydrolase

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2078560Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 2081496Superfamily c.1.8: (Trans)glycosidases [51445] (15 families) (S)
  5. 2082913Family c.1.8.4: Family 1 of glycosyl hydrolase [51521] (6 protein domains)

Protein Domains:

  1. 20829146-phospho-beta-D-galactosidase, PGAL [51526] (1 species)
  2. 2082923Beta-glucosidase A [51528] (9 species)
    1. 2082924Species Bacillus circulans, subsp. alkalophilus [TaxId:1397] [51530] (1 PDB entry)
    2. 2082941Species Bacillus polymyxa [TaxId:1406] [51529] (5 PDB entries)
    3. 2082956Species Clostridium cellulovorans [TaxId:1493] [189410] (1 PDB entry)
    4. 2082961Species Pyrococcus horikoshii [TaxId:53953] [141785] (1 PDB entry)
      Uniprot O58104 1-423
    5. 2082963Species Streptomyces sp. [TaxId:1931] [82248] (2 PDB entries)
    6. 2082968Species Thermotoga maritima [TaxId:2336] [89475] (8 PDB entries)
      Uniprot Q08638
    7. 2082981Species Thermus nonproteolyticus [TaxId:116039] [89477] (1 PDB entry)
    8. 2082984Species Thermus thermophilus [TaxId:274] [89476] (2 PDB entries)
    9. 2082987Species Uncultured bacterium [TaxId:77133] [188736] (6 PDB entries)
  3. 2082994beta-Glycosidase [51531] (2 species)
    1. 2082995Species Sulfolobus solfataricus [TaxId:2287] [51532] (9 PDB entries)
      Uniprot P22498
    2. 2083016Species Thermosphaera aggregans [TaxId:54254] [51533] (1 PDB entry)
  4. 2083019Plant beta-glucosidase (myrosinase) [51522] (4 species)
    1. 2083020Species Creeping white clover (Trifolium repens) [TaxId:3899] [51524] (1 PDB entry)
      Cyanogenic beta-glucosidase
    2. 2083022Species Maize (Zea mays), zmglu1 [TaxId:4577] [51525] (9 PDB entries)
      Uniprot P49235
    3. 2083041Species Sorghum (Sorghum bicolor) [TaxId:4558] [110351] (2 PDB entries)
      Uniprot Q41290
    4. 2083049Species White mustard (Sinapis alba) [TaxId:3728] [51523] (18 PDB entries)
  5. 2083068Thioglucosidase [141786] (1 species)
  6. 2083072automated matches [190245] (11 species)
    not a true protein
    1. 2083073Species Acidilobus saccharovorans [TaxId:666510] [194546] (2 PDB entries)
    2. 2083076Species Camellia sinensis [TaxId:4442] [256516] (3 PDB entries)
    3. 2083083Species Pyrococcus furiosus [TaxId:2261] [189762] (2 PDB entries)
    4. 2083092Species Secale cereale [TaxId:4550] [255749] (3 PDB entries)
    5. 2083096Species Sulfolobus solfataricus [TaxId:273057] [195161] (4 PDB entries)
    6. 2083101Species Thermotoga maritima [TaxId:2336] [187021] (20 PDB entries)
    7. 2083148Species Thermotoga maritima [TaxId:243274] [256277] (1 PDB entry)
    8. 2083152Species Thermus thermophilus HB8 [TaxId:300852] [193939] (1 PDB entry)
    9. 2083156Species Thermus thermophilus [TaxId:274] [193989] (1 PDB entry)
    10. 2083160Species Wheat (Triticum aestivum) [TaxId:4565] [255115] (4 PDB entries)
    11. 2286141Species Thermotoga neapolitana [TaxId:2337] [329442] (1 PDB entry)

More info for Family c.1.8.4: Family 1 of glycosyl hydrolase

Timeline for Family c.1.8.4: Family 1 of glycosyl hydrolase: