SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family c.1.8.3: beta-glycanases

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2078560Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 2081496Superfamily c.1.8: (Trans)glycosidases [51445] (15 families) (S)
  5. 2082160Family c.1.8.3: beta-glycanases [51487] (27 protein domains)
    consist of a number of sequence families

Protein Domains:

  1. 2082161Alkaline cellulase K catalytic domain [63906] (1 species)
  2. 2082165Alpha-L-arabinofuranosidase, catalytic domain [102075] (2 species)
    glycosyl hydrolase family 51
    1. 2082166Species Bacillus stearothermophilus [TaxId:1422] [102076] (4 PDB entries)
    2. 2082175Species Clostridium thermocellum [TaxId:1515] [141779] (2 PDB entries)
      Uniprot Q4CJG5 17-386
  3. 2082188Beta-1,4-galactanase [89469] (4 species)
    1. 2082189Species Bacillus licheniformis [TaxId:1402] [117367] (4 PDB entries)
      Uniprot Q65CX5 36-422 ! Uniprot Q65CX5 28-424
    2. 2082197Species Fungus (Aspergillus aculeatus) [TaxId:5053] [89470] (2 PDB entries)
    3. 2082200Species Fungus (Humicola insolens) [TaxId:34413] [89472] (1 PDB entry)
    4. 2082202Species Thielavia heterothallica, aka Myceliophthora thermophila [TaxId:78579] [89471] (2 PDB entries)
      Myceliophthora thermophila is the anamorph name whilst Thielavia heterothallica is the teleomorph name
  4. 2082211Beta-D-xylosidase, catalytic domain [102077] (2 species)
    glycosyl hydrolase family 39
    1. 2082212Species Bacillus stearothermophilus [TaxId:1422] [141780] (3 PDB entries)
      Uniprot Q9ZFM2 15-361
    2. 2082237Species Thermoanaerobacterium saccharolyticum [TaxId:28896] [102078] (2 PDB entries)
  5. 2082244beta-Galactosidase, domain 3 [51510] (2 species)
    1. 2082245Species Arthrobacter sp. c2-2 [TaxId:192168] [141778] (1 PDB entry)
      Uniprot Q8KRF6 313-609
    2. 2082252Species Escherichia coli [TaxId:562] [51511] (42 PDB entries)
      Uniprot P00722
  6. 2082453beta-Glucuronidase, domain 3 [51512] (1 species)
  7. 2082461Beta-mannanase [51502] (4 species)
    1. 2082462Species Bacillus sp. JAMB-602 [TaxId:244966] [141775] (1 PDB entry)
      Uniprot Q4W8M3 34-490
      contains additional C-terminal domain (CBM)
    2. 2082464Species Thermobifida fusca [TaxId:2021] [51503] (3 PDB entries)
    3. 2082468Species Tomato (Lycopersicon esculentum) [TaxId:4081] [141774] (1 PDB entry)
      Uniprot Q93WT4 30-399
    4. 2082470Species Trichoderma reesei [TaxId:51453] [51504] (5 PDB entries)
  8. 2082476endo-1,4-beta-mannosidase [141781] (1 species)
  9. 2082479Endocellulase E1 [51497] (1 species)
  10. 2082487Endocellulase EngI [75066] (1 species)
  11. 2082493Endoglucanase Cel5a [51499] (4 species)
    1. 2082494Species Bacillus agaradhaerens [TaxId:76935] [51500] (21 PDB entries)
      Uniprot O85465 30-329
    2. 2082516Species Bacillus subtilis [TaxId:1423] [75068] (1 PDB entry)
    3. 2082518Species Erwinia chrysanthemi [TaxId:556] [51501] (1 PDB entry)
    4. 2082522Species Pseudoalteromonas haloplanktis [TaxId:228] [141773] (2 PDB entries)
      Uniprot O86099 33-325
  12. 2082527Endoglucanase CelA [51491] (1 species)
  13. 2082530Endoglucanase CelC [51493] (1 species)
  14. 2082535Endoglucanase H N-terminal domain [141783] (1 species)
  15. 2082539Endoglucanase homologue TM1752 [102066] (1 species)
  16. 2082542Exo-beta-(1,3)-glucanase [51495] (2 species)
    1. 2082543Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [102065] (1 PDB entry)
    2. 2082546Species Yeast (Candida albicans) [TaxId:5476] [51496] (4 PDB entries)
  17. 2082551Exochitosanase CsxA [159383] (1 species)
  18. 2082559Exomannosidase [102068] (1 species)
    mannosyl-oligosaccharide glucosidase
  19. 2082563Five-domain beta-mannosidase, domain 3 [159385] (1 species)
  20. 2082569Glucosylceramidase, catalytic domain [89473] (1 species)
    acid-beta-glucosidase; glycosyl hydrolase family 30; contains additional beta-domain similar to one found in alpha amylases
  21. 2082623Glycosyl hydrolase family 5 xylanase, catalytic domain [102073] (1 species)
    overall domain organization is similar to the homologous glucosylceramidase
  22. 2082627Mannanase A, ManA [63908] (2 species)
    1. 2082628Species Cellulomonas fimi [TaxId:1708] [141776] (2 PDB entries)
      Uniprot Q9XCV5 55-420
    2. 2082632Species Pseudomonas cellulosa (Cellvibrio japonicus) [TaxId:155077] [63909] (5 PDB entries)
  23. 2082639Plant beta-glucanases [51507] (3 species)
    1. 2082640Species Banana (Musa acuminata), 1,3-beta-glucanase [TaxId:4641] [141777] (1 PDB entry)
      Uniprot O22317 29-340
    2. 2082642Species Barley (Hordeum vulgare), 1,3-1,4-beta-glucanase [TaxId:4513] [51509] (2 PDB entries)
    3. 2082646Species Barley (Hordeum vulgare), 1,3-beta-glucanase [TaxId:4513] [51508] (1 PDB entry)
  24. 2082649Xylanase [51488] (6 species)
    1. 2082650Species Bacillus stearothermophilus, Ixt6 [TaxId:1422] [102063] (7 PDB entries)
      intra-cellular xylanase
    2. 2082665Species Bacillus stearothermophilus, Xt6 [TaxId:1422] [69386] (8 PDB entries)
      Uniprot P40943
    3. 2082674Species Cellvibrio mixtus [TaxId:39650] [102064] (4 PDB entries)
    4. 2082679Species Clostridium thermocellum, XynZ [TaxId:1515] [51489] (1 PDB entry)
      belongs to family F
    5. 2082682Species Fungus (Penicillium simplicissimum) [TaxId:69488] [51490] (1 PDB entry)
      belongs to family 10
    6. 2082684Species Thermotoga maritima [TaxId:2336] [141772] (1 PDB entry)
      Uniprot Q9WXS5 23-346
  25. 2082686Xylanase 10c [102071] (1 species)
    Endo-beta-1,4-xylanase
  26. 2082690Xylanase A, catalytic core [51514] (8 species)
    1. 2082691Species Cellulomonas fimi [TaxId:1708] [51520] (14 PDB entries)
      synonym: beta-1,4-glycanase Cex
    2. 2082706Species Emericella nidulans (Aspergillus nidulans) [TaxId:162425] [110350] (1 PDB entry)
      Uniprot Q00177
    3. 2082708Species Fungus (Penicillium simplicissimum) [TaxId:69488] [51516] (7 PDB entries)
    4. 2082716Species Pseudomonas fluorescens [TaxId:294] [51517] (7 PDB entries)
      Uniprot P14768 265-610
    5. 2082733Species Streptomyces halstedii [TaxId:1944] [102070] (1 PDB entry)
    6. 2082735Species Streptomyces lividans [TaxId:1916] [51515] (9 PDB entries)
      Uniprot P26514 43-344
    7. 2082746Species Streptomyces olivaceoviridis [TaxId:1921] [51519] (12 PDB entries)
      Uniprot Q7SI98
      N-terminal domain; fused with a ricin A-like beta-trefoil domain
    8. 2082770Species Thermoascus aurantiacus [TaxId:5087] [51518] (11 PDB entries)
  27. 2082782automated matches [190057] (26 species)
    not a true protein
    1. 2082783Species Aspergillus niger [TaxId:425011] [311484] (1 PDB entry)
    2. 2082786Species Aspergillus niger [TaxId:5061] [260290] (4 PDB entries)
    3. 2082789Species Bacillus agaradhaerens [TaxId:76935] [187246] (1 PDB entry)
    4. 2082791Species Bacillus halodurans [TaxId:86665] [188453] (1 PDB entry)
    5. 2082793Species Bacillus licheniformis [TaxId:1402] [187025] (3 PDB entries)
    6. 2082799Species Bacillus sp. [TaxId:65673] [187690] (9 PDB entries)
    7. 2082809Species Bacillus sp. [TaxId:89769] [189058] (3 PDB entries)
    8. 2082813Species Bacteroides thetaiotaomicron [TaxId:226186] [255614] (7 PDB entries)
    9. Species Bacteroides thetaiotaomicron [TaxId:818] [255622] (1 PDB entry)
    10. 2082831Species Cellulomonas fimi [TaxId:1708] [231537] (1 PDB entry)
    11. 2082834Species Cellvibrio mixtus [TaxId:39650] [255089] (1 PDB entry)
    12. 2082836Species Clostridium thermocellum [TaxId:1515] [187247] (4 PDB entries)
    13. 2082841Species Emericella nidulans [TaxId:162425] [226738] (1 PDB entry)
    14. 2082843Species Hypocrea jecorina [TaxId:431241] [311485] (1 PDB entry)
    15. 2082845Species Podospora anserina [TaxId:5145] [256160] (1 PDB entry)
    16. 2082847Species Pseudomonas cellulosa (Cellvibrio japonicus) [TaxId:155077] [188920] (1 PDB entry)
    17. 2082849Species Rubber tree (Hevea brasiliensis) [TaxId:3981] [189057] (4 PDB entries)
    18. 2082866Species Soil metagenome [TaxId:410658] [236610] (2 PDB entries)
    19. 2082871Species Streptomyces olivaceoviridis [TaxId:1921] [225150] (8 PDB entries)
    20. 2082886Species Streptomyces thermolilacinus [TaxId:285540] [272999] (2 PDB entries)
    21. 2082891Species Thermoascus aurantiacus [TaxId:5087] [190006] (5 PDB entries)
    22. 2082899Species Thermotoga petrophila [TaxId:390874] [189941] (2 PDB entries)
    23. 2082904Species Yeast (Candida albicans) [TaxId:5476] [188406] (8 PDB entries)
    24. 2268447Species Geobacillus sp. [TaxId:575526] [311753] (1 PDB entry)
    25. 2268882Species Bacillus sp. [TaxId:253629] [312188] (1 PDB entry)
    26. 2287033Species Talaromyces verruculosus [TaxId:198730] [330334] (2 PDB entries)

More info for Family c.1.8.3: beta-glycanases

Timeline for Family c.1.8.3: beta-glycanases: