Lineage for Protein: Inosine monophosphate dehydrogenase (IMPDH)

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 814174Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 814982Superfamily c.1.5: Inosine monophosphate dehydrogenase (IMPDH) [51412] (1 family) (S)
    The phosphate moiety of substrate binds in the 'common' phosphate-binding site
  5. 814983Family c.1.5.1: Inosine monophosphate dehydrogenase (IMPDH) [51413] (1 protein)
  6. 814984Protein Inosine monophosphate dehydrogenase (IMPDH) [51414] (8 species)

Species:

  1. 814985Chinese hamster (Cricetulus griseus) [TaxId:10029] [63902] (1 PDB entry)
  2. 814988Human (Homo sapiens), type I [TaxId:9606] [89456] (1 PDB entry)
  3. 814991Human (Homo sapiens), type II [TaxId:9606] [51418] (3 PDB entries)
    1. Domains for 1b3o:
      1. 814992Domain d1b3oa1: 1b3o A:10-109,A:232-499 [28640]
        Other proteins in same PDB: d1b3ob4
        contains two CBS domains inserted into the common fold, residues 112-231
      2. 814993Domain d1b3ob1: 1b3o B:10-111,B:232-499 [28641]
        Other proteins in same PDB: d1b3ob4
        contains two CBS domains inserted into the common fold, residues 112-231
        complexed with cpr, sae
    2. Domains for 1nf7:
      1. 814994Domain d1nf7a1: 1nf7 A:10-111,A:232-514 [91852]
        Other proteins in same PDB: d1nf7a4, d1nf7b4
      2. 814995Domain d1nf7b1: 1nf7 B:10-111,B:232-514 [91855]
        Other proteins in same PDB: d1nf7a4, d1nf7b4
        complexed with k, myd, rvp
    3. Domains for 1nfb:
      1. 814996Domain d1nfba1: 1nfb A:10-111,A:232-498 [91858]
        Other proteins in same PDB: d1nfba4, d1nfbb4
      2. 814997Domain d1nfbb1: 1nfb B:10-111,B:232-498 [91861]
        Other proteins in same PDB: d1nfba4, d1nfbb4
        complexed with cpr, nad
  4. 814998Lyme disease spirochete (Borrelia burgdorferi) [TaxId:139] [51415] (1 PDB entry)
  5. 815001Pyrococcus horikoshii [TaxId:53953] [159379] (1 PDB entry)
    Uniprot O58045 3-96,207-480
  6. 815003Streptococcus pyogenes [TaxId:1314] [51416] (1 PDB entry)
  7. 815005Thermotoga maritima [TaxId:2336] [159378] (1 PDB entry)
    Uniprot Q9X168 1-85,213-457
  8. 815007Tritrichomonas foetus [TaxId:5724] [51417] (9 PDB entries)
    1. Domain for 1ak5:
    2. Domains for 1lrt:
      1. 815016Domain d1lrta1: 1lrt A:2-100,A:231-485 [84685]
        there are two CBS domains in the disordered region 101-230
      2. 815017Domain d1lrtb1: 1lrt B:2-100,B:231-485 [84686]
        there are two CBS domains in the disordered region 101-230
      3. 815018Domain d1lrtc1: 1lrt C:2-100,C:231-485 [84687]
        there are two CBS domains in the disordered region 101-230
      4. 815019Domain d1lrtd1: 1lrt D:2-100,D:231-485 [84688]
        there are two CBS domains in the disordered region 101-230
        complexed with bog, imp, k, tad, trs
    3. Domain for 1me7:
    4. Domain for 1me8:
    5. Domain for 1me9:
    6. Domain for 1meh:
    7. Domain for 1mei:
    8. Domain for 1mew:
    9. Domains for 1pvn:
      1. 815008Domain d1pvna1: 1pvn A:2-99,A:231-494 [88312]
        there are two CBS domains in the disordered region 100-230
      2. 815009Domain d1pvnb1: 1pvn B:2-99,B:231-494 [88313]
        there are two CBS domains in the disordered region 100-230
      3. 815010Domain d1pvnc1: 1pvn C:2-99,C:231-494 [88314]
        there are two CBS domains in the disordered region 100-230
      4. 815011Domain d1pvnd1: 1pvn D:2-99,D:231-494 [88315]
        there are two CBS domains in the disordered region 100-230
        complexed with k, mzp, trs

More info for Protein Inosine monophosphate dehydrogenase (IMPDH) from c.1.5.1: Inosine monophosphate dehydrogenase (IMPDH)

Timeline for Protein Inosine monophosphate dehydrogenase (IMPDH) from c.1.5.1: Inosine monophosphate dehydrogenase (IMPDH):