SCOPe 2.01: Protein: Dihydroorotate dehydrogenase

Lineage for Protein: Dihydroorotate dehydrogenase

Root: SCOPe 2.01
Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
the first seven superfamilies have similar phosphate-binding sites

Superfamily c.1.4: FMN-linked oxidoreductases [51395] (2 families)
Family c.1.4.1: FMN-linked oxidoreductases [51396] (19 proteins)
Protein Dihydroorotate dehydrogenase [51397] (7 species)

Species:

Escherichia coli [TaxId:562] [82239] (1 PDB entry)
- Domains for 1f76:
  1. Domain d1f76a_: 1f76 A: [76160]
    complexed with fmn, fmt, oro
  2. Domain d1f76b_: 1f76 B: [76161]
    complexed with fmn, fmt, oro
  3. Domain d1f76d_: 1f76 D: [76162]
    complexed with fmn, fmt, oro
  4. Domain d1f76e_: 1f76 E: [76163]
    complexed with fmn, fmt, oro
Human (Homo sapiens) [TaxId:9606] [51400] (11 PDB entries)
1. Domain for 1d3g:
  - Domain d1d3ga_: 1d3g A: [28600]
    complexed with act, bre, ddq, fmn, oro, so4
2. Domain for 1d3h:
  - Domain d1d3ha_: 1d3h A: [28601]
    complexed with a26, act, fmn, oro, so4
3. Domain for 2b0m:
  - Domain d2b0ma1: 2b0m A:33-396 [127644]
    automatically matched to d1d3ga_
    complexed with 201, fmn, oro
4. Domain for 2fpt:
  - Domain d2fpta1: 2fpt A:30-396 [133923]
    automatically matched to d1d3ga_
    complexed with act, fmn, ilb, oro, so4
5. Domain for 2fpv:
  - Domain d2fpva1: 2fpv A:33-396 [133926]
    automatically matched to d1d3ga_
    complexed with act, fmn, ilc, oro, so4
6. Domain for 2fpy:
  - Domain d2fpya1: 2fpy A:33-396 [133931]
    automatically matched to d1d3ga_
    complexed with act, fmn, ilf, oro, so4
7. Domain for 2fqi:
  - Domain d2fqia1: 2fqi A:34-396 [133955]
    automatically matched to d1d3ga_
    complexed with act, fmn, ilh, oro, so4
8. Domain for 2prh:
  - Domain d2prha_: 2prh A: [149800]
    automated match to d1d3ga_
    complexed with 238, ddq, fmn, oro
9. Domain for 2prl:
  - Domain d2prla_: 2prl A: [149801]
    automated match to d1d3ga_
    complexed with act, ddq, fmn, oro, r2c, so4
10. Domain for 2prm:
  - Domain d2prma1: 2prm A:30-396 [149802]
    automatically matched to d1d3ga_
    complexed with fmn, oro
11. Domain for 3f1q:
  - Domain d3f1qa_: 3f1q A: [175415]
    automated match to d1d3ga_
    complexed with acy, bce, fmn, oro, so4
Lactococcus lactis, isozyme A [TaxId:1358] [51398] (9 PDB entries)
1. Domains for 1dor:
  1. Domain d1dora_: 1dor A: [28595]
    complexed with fmn
  2. Domain d1dorb_: 1dor B: [28596]
    complexed with fmn
2. Domains for 1jqv:
  1. Domain d1jqva_: 1jqv A: [90900]
    complexed with acy, fmn, mg, oro; mutant
  2. Domain d1jqvb_: 1jqv B: [90901]
    complexed with acy, fmn, mg, oro; mutant
3. Domains for 1jqx:
  1. Domain d1jqxa_: 1jqx A: [90902]
    complexed with fmn, gol, mg, oro; mutant
  2. Domain d1jqxb_: 1jqx B: [90903]
    complexed with fmn, gol, mg, oro; mutant
4. Domains for 1jrb:
  1. Domain d1jrba_: 1jrb A: [90904]
    complexed with fmn, oro; mutant
  2. Domain d1jrbb_: 1jrb B: [90905]
    complexed with fmn, oro; mutant
5. Domains for 1jrc:
  1. Domain d1jrca_: 1jrc A: [90906]
    complexed with fmn, oro; mutant
  2. Domain d1jrcb_: 1jrc B: [90907]
    complexed with fmn, oro; mutant
6. Domains for 1jub:
  1. Domain d1juba_: 1jub A: [90908]
    complexed with fmn, gol, mg; mutant
  2. Domain d1jubb_: 1jub B: [90909]
    complexed with fmn, gol, mg; mutant
7. Domains for 1jue:
  1. Domain d1juea_: 1jue A: [90910]
    complexed with acy, fmn, gol, mg
  2. Domain d1jueb_: 1jue B: [90911]
    complexed with acy, fmn, gol, mg
8. Domains for 1ovd:
  1. Domain d1ovda_: 1ovd A: [93593]
    complexed with fmn, gol, mg, oro; mutant
  2. Domain d1ovdb_: 1ovd B: [93594]
    complexed with fmn, gol, mg, oro; mutant
9. Domains for 2dor:
  1. Domain d2dora_: 2dor A: [28593]
    complexed with fmn, oro
  2. Domain d2dorb_: 2dor B: [28594]
    complexed with fmn, oro
Lactococcus lactis, isozyme B [TaxId:1358] [51399] (3 PDB entries)
PyrD subunit
1. Domain for 1ep1:
  - Domain d1ep1a_: 1ep1 A: [28598]
    Other proteins in same PDB: d1ep1b1, d1ep1b2
    complexed with fad, fes, fmn
2. Domain for 1ep2:
  - Domain d1ep2a_: 1ep2 A: [28599]
    Other proteins in same PDB: d1ep2b1, d1ep2b2
    complexed with fad, fes, fmn, oro
3. Domain for 1ep3:
  - Domain d1ep3a_: 1ep3 A: [28597]
    Other proteins in same PDB: d1ep3b1, d1ep3b2
    complexed with fad, fes, fmn
Malaria parasite (Plasmodium falciparum) [TaxId:5833] [141759] (1 PDB entry)
Uniprot Q08210 158-566
homolog, mitochonrial
- Domain for 1tv5:
  - Domain d1tv5a1: 1tv5 A:158-566 [119347]
    complexed with a26, fmn, n8e, oro, so4
Norway rat (Rattus norvegicus) [TaxId:10116] [102039] (2 PDB entries)
1. Domains for 1uum:
  1. Domain d1uuma_: 1uum A: [100010]
    complexed with afi, bog, fmn, oro
  2. Domain d1uumb_: 1uum B: [100011]
    complexed with afi, bog, fmn, oro
2. Domain for 1uuo:
  - Domain d1uuoa_: 1uuo A: [100014]
    complexed with brf, fmn, na, ni, oro
Trypanosome (Trypanosoma brucei) [TaxId:5691] [141758] (1 PDB entry)
Uniprot Q57U83 2-313
- Domain for 2b4g:
  - Domain d2b4ga1: 2b4g A:2-313 [127829]
    Other proteins in same PDB: d2b4gb_, d2b4gc_, d2b4gd_
    complexed with br, fmn, gol, oro

More info for Protein Dihydroorotate dehydrogenase from c.1.4.1: FMN-linked oxidoreductases

Timeline for Protein Dihydroorotate dehydrogenase from c.1.4.1: FMN-linked oxidoreductases:

Protein Dihydroorotate dehydrogenase from c.1.4.1: FMN-linked oxidoreductases first appeared (with stable ids) in SCOP 1.55
Protein Dihydroorotate dehydrogenase from c.1.4.1: FMN-linked oxidoreductases appears in SCOP 1.75
Protein Dihydroorotate dehydrogenase from c.1.4.1: FMN-linked oxidoreductases appears in SCOPe 2.02
Protein Dihydroorotate dehydrogenase from c.1.4.1: FMN-linked oxidoreductases appears in the current release, SCOPe 2.08