SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family c.1.2.1: Histidine biosynthesis enzymes

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2078560Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
    contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
    the first seven superfamilies have similar phosphate-binding sites
  4. 2079053Superfamily c.1.2: Ribulose-phoshate binding barrel [51366] (7 families) (S)
  5. 2079054Family c.1.2.1: Histidine biosynthesis enzymes [51367] (3 protein domains)
    structural evidence for the gene duplication within the barrel fold
    automatically mapped to Pfam PF00977

Protein Domains:

  1. 2079055Cyclase subunit (or domain) of imidazoleglycerolphosphate synthase HisF [51370] (4 species)
    1. 2079056Species Baker's yeast (Saccharomyces cerevisiae), His7 [TaxId:4932] [69379] (4 PDB entries)
    2. 2079065Species Pyrobaculum aerophilum [TaxId:13773] [69380] (1 PDB entry)
    3. 2079068Species Thermotoga maritima [TaxId:2336] [51371] (5 PDB entries)
    4. 2079080Species Thermus thermophilus [TaxId:274] [82237] (1 PDB entry)
  2. 2079082Phosphoribosylformimino-5-aminoimidazole carboxamide ribotite isomerase HisA [51368] (2 species)
    1. 2079083Species Streptomyces coelicolor [TaxId:1902] [141744] (1 PDB entry)
      Uniprot P16250 2-240
    2. 2079085Species Thermotoga maritima [TaxId:2336] [51369] (2 PDB entries)
  3. 2079090automated matches [190186] (10 species)
    not a true protein
    1. 2079091Species Actinomyces urogenitalis [TaxId:525246] [269148] (1 PDB entry)
    2. 2079093Species Arthrobacter aurescens [TaxId:43663] [260126] (1 PDB entry)
    3. 2079095Species Corynebacterium efficiens [TaxId:152794] [226694] (1 PDB entry)
    4. 2079098Species Mycobacterium tuberculosis [TaxId:83332] [189657] (4 PDB entries)
    5. 2079106Species Streptomyces coelicolor [TaxId:100226] [277529] (1 PDB entry)
    6. 2079108Species Streptomyces coelicolor [TaxId:1902] [189237] (2 PDB entries)
    7. 2079111Species Streptomyces sp. [TaxId:465541] [259607] (2 PDB entries)
    8. 2079114Species Streptomyces sviceus [TaxId:463191] [258540] (2 PDB entries)
    9. 2079117Species Thermotoga maritima [TaxId:2336] [186925] (4 PDB entries)
    10. 2283013Species Thermotoga maritima [TaxId:243274] [326314] (1 PDB entry)

More info for Family c.1.2.1: Histidine biosynthesis enzymes

Timeline for Family c.1.2.1: Histidine biosynthesis enzymes: