SCOP 1.75: Family b.68.1.1: Sialidases (neuraminidases)

Lineage for Family b.68.1.1: Sialidases (neuraminidases)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.68: 6-bladed beta-propeller [50938] (11 superfamilies)
   consists of six 4-stranded beta-sheet motifs; meander

4. Superfamily b.68.1: Sialidases [50939] (2 families)

5. Family b.68.1.1: Sialidases (neuraminidases) [50940] (9 proteins)

Proteins:

1. Hemagglutinin-neuraminidase glycoprotein [101891] (1 species)

   • Species Human parainfluenza virus type 3 [TaxId:11216] [101892] (5 PDB entries)

2. Influenza neuraminidase [50943] (2 species)

   1. Species Influenza A virus, different strains [TaxId:11320] [50944] (54 PDB entries)
      Uniprot P03472 84-470

   2. Species Influenza B virus, different strains [TaxId:11520] [50945] (12 PDB entries)

3. Leech intramolecular trans-sialidase, C-terminal domain [50948] (1 species)
   contains incomplete beta-barrel subdomain inserted in the second blade

   • Species North american leech (Macrobdella decora) [TaxId:6405] [50949] (5 PDB entries)

4. Micromonospora sialidase, N-terminal domain [50946] (1 species)

   • Species Micromonospora viridifaciens [TaxId:1881] [50947] (8 PDB entries)
     Uniprot Q02834 47-647

5. Paramyxovirus hemagglutinin-neuraminidase head domain [63823] (1 species)

   • Species Newcastle disease virus [TaxId:11176] [63824] (5 PDB entries)

6. Salmonella sialidase [50941] (1 species)

   • Species Salmonella typhimurium, strain lt2 [TaxId:90371] [50942] (5 PDB entries)

7. Sialidase 2 (Neu2) [117274] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [117275] (8 PDB entries)
     Uniprot Q9Y3R4

8. Trypanosoma sialidase [82164] (2 species)

   1. Species Parasitic flagellate protozoan (Trypanosoma cruzi) [TaxId:5693] [89371] (12 PDB entries)
      Uniprot Q26966

   2. Species Trypanosoma rangeli [TaxId:5698] [82165] (10 PDB entries)
      Uniprot O44049 20-653

9. Vibrio cholerae sialidase [50950] (1 species)
   contains 2 additional domains of ConA-like fold

   • Species Vibrio cholerae [TaxId:666] [50951] (3 PDB entries)
     Uniprot P37060

More info for Family b.68.1.1: Sialidases (neuraminidases)

Timeline for Family b.68.1.1: Sialidases (neuraminidases):

• Family b.68.1.1: Sialidases (neuraminidases) first appeared (with stable ids) in SCOP 1.55
  
• Family b.68.1.1: Sialidases (neuraminidases) appears in SCOP 1.73
  
• Family b.68.1.1: Sialidases (neuraminidases) appears in SCOPe 2.01
  
• Family b.68.1.1: Sialidases (neuraminidases) appears in the current release, SCOPe 2.08