Lineage for Family b.55.1.2: Phosphotyrosine-binding domain (PTB)

  1. Root: SCOPe 2.06
  2. 2021373Class b: All beta proteins [48724] (177 folds)
  3. 2070980Fold b.55: PH domain-like barrel [50728] (2 superfamilies)
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
  4. 2070981Superfamily b.55.1: PH domain-like [50729] (14 families) (S)
  5. 2071257Family b.55.1.2: Phosphotyrosine-binding domain (PTB) [50755] (13 proteins)
    Pfam PF00640

Proteins:

  1. 2071258Amyloid beta A4 precursor protein-binding family B member 2, Apbb2 [117259] (1 species)
  2. 2071262Disabled homolog 1 (Dab1) [89357] (1 species)
  3. 2071268Disabled homolog 2 (Dab2) [101830] (1 species)
  4. 2071276Docking protein 1, Dok1 [101834] (1 species)
  5. 2071282Downstream of tyrosine kinase 5, Dok-5 [101832] (1 species)
  6. 2071286EPS8-like protein 1, EPS8L1 [141424] (1 species)
  7. 2071289FGFR substrate 2 (SNT-1) [117257] (1 species)
  8. 2071292Insulin receptor substrate 1, IRS-1 [50758] (1 species)
    duplication: contains two domains of this fold
  9. 2071299Numb [50762] (3 species)
    1. 2071300Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [50763] (2 PDB entries)
    2. 2071303Species Homo sapiens [TaxId:9606] [342799] (1 PDB entry)
    3. 2071307Species Mouse (Mus musculus) [TaxId:10090] [117256] (1 PDB entry)
      Uniprot Q9QZS3 19-172
  10. 2071309Shc adaptor protein [50760] (1 species)
  11. 2071314Tensin [141421] (2 species)
    1. 2071315Species Chicken (Gallus gallus) [TaxId:9031] [141423] (1 PDB entry)
      Uniprot Q04205 1606-1738
    2. 2071317Species Human (Homo sapiens) [TaxId:9606] [141422] (2 PDB entries)
      Uniprot Q9UPS7 1139-1285
      Tensin2
  12. 2071320X11 [50756] (1 species)
  13. 2071326automated matches [190580] (4 species)
    not a true protein
    1. 2071327Species Chicken (Gallus gallus) [TaxId:9031] [255189] (1 PDB entry)
    2. 2071329Species Human (Homo sapiens) [TaxId:9606] [188312] (4 PDB entries)
    3. 2071337Species Mouse (Mus musculus) [TaxId:10090] [187584] (1 PDB entry)
    4. 2071339Species Norway rat (Rattus norvegicus) [TaxId:10116] [226324] (1 PDB entry)

More info for Family b.55.1.2: Phosphotyrosine-binding domain (PTB)

Timeline for Family b.55.1.2: Phosphotyrosine-binding domain (PTB):