SCOPe 2.03: Family b.55.1.2: Phosphotyrosine-binding domain (PTB)

Lineage for Family b.55.1.2: Phosphotyrosine-binding domain (PTB)

1. Root: SCOPe 2.03

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.55: PH domain-like barrel [50728] (2 superfamilies)
   barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix

4. Superfamily b.55.1: PH domain-like [50729] (14 families)

5. Family b.55.1.2: Phosphotyrosine-binding domain (PTB) [50755] (13 proteins)
   Pfam PF00640

Proteins:

1. Amyloid beta A4 precursor protein-binding family B member 2, Apbb2 [117259] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [117260] (2 PDB entries)
     Uniprot Q9DBR4 582-704

2. Disabled homolog 1 (Dab1) [89357] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [89358] (3 PDB entries)

3. Disabled homolog 2 (Dab2) [101830] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [101831] (2 PDB entries)

4. Docking protein 1, Dok1 [101834] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [101835] (2 PDB entries)
     Uniprot P97465 152-254

5. Downstream of tyrosine kinase 5, Dok-5 [101832] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [101833] (1 PDB entry)

6. EPS8-like protein 1, EPS8L1 [141424] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [141425] (1 PDB entry)
     Uniprot Q8R5F8 31-159

7. FGFR substrate 2 (SNT-1) [117257] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [117258] (1 PDB entry)
     Uniprot Q7LDQ6 11-129

8. Insulin receptor substrate 1, IRS-1 [50758] (1 species)
   duplication: contains two domains of this fold

   • Species Human (Homo sapiens) [TaxId:9606] [50759] (2 PDB entries)

9. Numb [50762] (2 species)

   1. Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [50763] (2 PDB entries)

   2. Species Mouse (Mus musculus) [TaxId:10090] [117256] (1 PDB entry)
      Uniprot Q9QZS3 19-172

10. Shc adaptor protein [50760] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50761] (3 PDB entries)

11. Tensin [141421] (2 species)

    1. Species Chicken (Gallus gallus) [TaxId:9031] [141423] (1 PDB entry)
       Uniprot Q04205 1606-1738

    2. Species Human (Homo sapiens) [TaxId:9606] [141422] (1 PDB entry)
       Uniprot Q9UPS7 1139-1285
       Tensin2

12. X11 [50756] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50757] (2 PDB entries)

13. automated matches [190580] (3 species)
    not a true protein

    1. Species Human (Homo sapiens) [TaxId:9606] [188312] (3 PDB entries)

    2. Species Mouse (Mus musculus) [TaxId:10090] [187584] (1 PDB entry)

    3. Species Norway rat (Rattus norvegicus) [TaxId:10116] [226324] (1 PDB entry)

More info for Family b.55.1.2: Phosphotyrosine-binding domain (PTB)

Timeline for Family b.55.1.2: Phosphotyrosine-binding domain (PTB):

• Family b.55.1.2: Phosphotyrosine-binding domain (PTB) first appeared (with stable ids) in SCOP 1.55
  
• Family b.55.1.2: Phosphotyrosine-binding domain (PTB) appears in SCOPe 2.02
  
• Family b.55.1.2: Phosphotyrosine-binding domain (PTB) appears in SCOPe 2.04
  
• Family b.55.1.2: Phosphotyrosine-binding domain (PTB) appears in the current release, SCOPe 2.08