Lineage for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

  1. Root: SCOPe 2.05
  2. 1755445Class b: All beta proteins [48724] (176 folds)
  3. 1798838Fold b.55: PH domain-like barrel [50728] (2 superfamilies)
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
  4. 1798839Superfamily b.55.1: PH domain-like [50729] (14 families) (S)
  5. 1798840Family b.55.1.1: Pleckstrin-homology domain (PH domain) [50730] (48 proteins)
    Pfam PF00169

Proteins:

  1. 17988413-phosphoinositide dependent protein kinase-1 [117246] (1 species)
  2. 1798849Alpha-1-syntrophin [141411] (1 species)
  3. 1798852beta-spectrin [50733] (3 species)
    1. 1798853Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [50735] (1 PDB entry)
    2. 1798855Species Human (Homo sapiens), brain 2 isoform [TaxId:9606] [117243] (1 PDB entry)
      Uniprot O15020 2219-2324
    3. 1798857Species Mouse (Mus musculus), brain [TaxId:10090] [50734] (2 PDB entries)
  4. 1798860Bruton's tyrosine kinase [50738] (1 species)
    contains Btk zinc-binding motif
  5. 1798868Calcium-dependent activator protein for secretion, CAPS [117252] (1 species)
  6. 1798871Centaurin-delta 1 [141395] (1 species)
  7. 1798874Cytohesin 2 [141401] (1 species)
  8. 1798878Cytohesin 3 [141397] (1 species)
  9. 1798881Dbl's big sister, Dbs [74989] (1 species)
    • 1798882Species Mouse (Mus musculus) [TaxId:10090] [74990] (4 PDB entries)
      SQ Q64096 624-958 # 98% sequence identity; the rat sequence Q63406 region 499-833 is 100% identical to the PDB sequence
  10. 1798895DCC-interacting protein 13-alpha, APPL1 [159211] (1 species)
  11. 1798898Dedicator of cytokinesis protein 9, DOCK9 [117248] (1 species)
  12. 1798901Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH [50749] (1 species)
  13. 1798905Dynamin [50736] (1 species)
  14. 1798911Exocyst complex protein EXO84 [141399] (1 species)
  15. 1798914FYVE, RhoGEF and PH domain containing protein 3, FGD3 [141415] (1 species)
  16. 1798917FYVE, RhoGEF and PH domain containing protein 6, Fgd6 (KIAA1362) [117250] (1 species)
  17. 1798920G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1) [50747] (2 species)
    1. 1798921Species Cow (Bos taurus) [TaxId:9913] [89354] (6 PDB entries)
    2. 1798931Species Human (Homo sapiens) [TaxId:9606] [50748] (1 PDB entry)
  18. 1798933GEF of intersectin [74991] (1 species)
  19. 1798937GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1) [50745] (1 species)
  20. 1798943Grp1 [50751] (1 species)
    ARF1 Guanine nucleotide exchange factor and integrin binding protein homolog
  21. 1798955KIAA1914 [141407] (1 species)
  22. 1798958Oxysterol binding protein-related protein 8 (ORP-8, KIAA1451) [110266] (1 species)
  23. 1798961Phosphoinositide phospholipase C, PLC-gamma-1 [141413] (1 species)
    contains split PH domain
  24. 1798964Phosphoinositol 3-phosphate binding protein-1, PEPP1 [117244] (1 species)
  25. 1798968Phospholipase C delta-1 [50731] (1 species)
  26. 1798971Phospholipase C-beta-2 [159207] (1 species)
  27. 1798975Pleckstrin [50740] (1 species)
  28. 1798985Pleckstrin-2 [141409] (1 species)
  29. 1798988Protein kinase c, d2 type [141419] (1 species)
  30. 1798991Rac-alpha serine/threonine kinase [89355] (1 species)
  31. 1798997Rac-beta serine/threonine protein kinase (PKB/AKT) [110254] (1 species)
  32. 1799000Rac/CDC42 GEF 6, alpha-pix [110262] (1 species)
  33. 1799003Rho GTPase-activating protein 21 [159213] (1 species)
  34. 1799011Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF [117254] (1 species)
  35. 1799019Rho guanine nucleotide exchange factor 12 [110270] (1 species)
  36. 1799026Rho guanine nucleotide exchange factor 9, Collybistin [159209] (1 species)
  37. 1799030Rho-GTPase-activating protein 25 (KIAA0053) [110268] (1 species)
  38. 1799033SET binding factor 1, Sbf1 [110260] (1 species)
  39. 1799036SH2 and PH domain-containing adapter protein APS [110256] (1 species)
  40. 1799039Signal-transducing adaptor protein 1, STAP-1 [141405] (1 species)
  41. 1799042Son of sevenless-1 (sos-1) [50742] (2 species)
    1. 1799043Species Human (Homo sapiens) [TaxId:9606] [50744] (4 PDB entries)
      Uniprot Q07889 189-1046
    2. 1799050Species Mouse (Mus musculus) [TaxId:10090] [50743] (1 PDB entry)
  42. 1799052Src kinase-associated phosphoprotein SKAP55 (SCAP1) [141403] (1 species)
  43. 1799058Src-associated adaptor protein Skap2 [141417] (1 species)
  44. 1799069Tapp1 [74993] (1 species)
  45. 1799072Tapp2 [110258] (1 species)
  46. 1799075Triple functional domain protein TRIO [110264] (1 species)
  47. 1799079UNC-89 [50753] (1 species)
  48. 1799082automated matches [190063] (3 species)
    not a true protein
    1. 1799083Species Bos taurus [TaxId:9913] [270894] (1 PDB entry)
    2. 1799088Species Human (Homo sapiens) [TaxId:9606] [187187] (8 PDB entries)
    3. 1799107Species Norway rat (Rattus norvegicus) [TaxId:10116] [188181] (2 PDB entries)

More info for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

Timeline for Family b.55.1.1: Pleckstrin-homology domain (PH domain):