Lineage for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

  1. Root: SCOP 1.73
  2. 651986Class b: All beta proteins [48724] (165 folds)
  3. 672997Fold b.55: PH domain-like barrel [50728] (2 superfamilies)
    barrel, partly opened; n*=6, S*=12; meander; capped by an alpha-helix
  4. 672998Superfamily b.55.1: PH domain-like [50729] (12 families) (S)
  5. 672999Family b.55.1.1: Pleckstrin-homology domain (PH domain) [50730] (43 proteins)
    Pfam PF00169

Proteins:

  1. 6730003-phosphoinositide dependent protein kinase-1 [117246] (1 species)
  2. 673008Alpha-1-syntrophin [141411] (1 species)
  3. 673011beta-spectrin [50733] (3 species)
    1. 673012Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [50735] (1 PDB entry)
    2. 673014Species Human (Homo sapiens), brain 2 isoform [TaxId:9606] [117243] (1 PDB entry)
    3. 673016Species Mouse (Mus musculus), brain [TaxId:10090] [50734] (2 PDB entries)
  4. 673019Bruton's tyrosine kinase [50738] (1 species)
    contains Btk zinc-binding motif
  5. 673027Calcium-dependent activator protein for secretion, CAPS [117252] (1 species)
  6. 673030Centaurin-delta 1 [141395] (1 species)
  7. 673033Cytohesin 2 [141401] (1 species)
  8. 673037Cytohesin 3 [141397] (1 species)
  9. 673040Dbl's big sister, Dbs [74989] (1 species)
  10. 673054Dedicator of cytokinesis protein 9, DOCK9 [117248] (1 species)
  11. 673057Dual adaptor of phosphotyrosine and 3-phosphoinositides DAPP1/PHISH [50749] (1 species)
  12. 673061Dynamin [50736] (1 species)
  13. 673067Exocyst complex protein EXO84 [141399] (1 species)
  14. 673073FYVE, RhoGEF and PH domain containing protein 3, FGD3 [141415] (1 species)
  15. 673076FYVE, RhoGEF and PH domain containing protein 6, Fgd6 (KIAA1362) [117250] (1 species)
  16. 673079G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1) [50747] (2 species)
    1. 673080Species Cow (Bos taurus) [TaxId:9913] [89354] (3 PDB entries)
    2. 673087Species Human (Homo sapiens) [TaxId:9606] [50748] (1 PDB entry)
  17. 673089GEF of intersectin [74991] (1 species)
  18. 673093GEF of TIAM1 (T-Lymphoma invasion and metastasis inducing protein 1) [50745] (1 species)
  19. 673099Grp1 [50751] (1 species)
    ARF1 Guanine nucleotide exchange factor and integrin binding protein homolog
  20. 673107KIAA1914 [141407] (1 species)
  21. 673110Oxysterol binding protein-related protein 8 (ORP-8, KIAA1451) [110266] (1 species)
  22. 673113Phosphoinositide phospholipase C, PLC-gamma-1 [141413] (1 species)
    contains split PH domain
  23. 673116Phosphoinositol 3-phosphate binding protein-1, PEPP1 [117244] (1 species)
  24. 673120Phospholipase C delta-1 [50731] (1 species)
  25. 673123Pleckstrin [50740] (1 species)
  26. 673130Pleckstrin-2 [141409] (1 species)
  27. 673133Protein kinase c, d2 type [141419] (1 species)
  28. 673136Rac-alpha serine/threonine kinase [89355] (1 species)
  29. 673143Rac-beta serine/threonine protein kinase (PKB/AKT) [110254] (1 species)
  30. 673146Rac/CDC42 GEF 6, alpha-pix [110262] (1 species)
  31. 673149Rho guanine nucleotide exchange factor 11, PDZ-RhoGEF [117254] (1 species)
  32. 673153Rho guanine nucleotide exchange factor 12 [110270] (1 species)
  33. 673160Rho-GTPase-activating protein 25 (KIAA0053) [110268] (1 species)
  34. 673163SET binding factor 1, Sbf1 [110260] (1 species)
  35. 673166SH2 and PH domain-containing adapter protein APS [110256] (1 species)
  36. 673169Signal-transducing adaptor protein 1, STAP-1 [141405] (1 species)
  37. 673172Son of sevenless-1 (sos-1) [50742] (2 species)
    1. 673173Species Human (Homo sapiens) [TaxId:9606] [50744] (4 PDB entries)
    2. 673180Species Mouse (Mus musculus) [TaxId:10090] [50743] (1 PDB entry)
  38. 673182Src kinase-associated phosphoprotein SKAP55 (SCAP1) [141403] (1 species)
  39. 673188Src-associated adaptor protein Skap2 [141417] (1 species)
  40. 673199Tapp1 [74993] (1 species)
  41. 673202Tapp2 [110258] (1 species)
  42. 673205Triple functional domain protein TRIO [110264] (1 species)
  43. 673209UNC-89 [50753] (1 species)

More info for Family b.55.1.1: Pleckstrin-homology domain (PH domain)

Timeline for Family b.55.1.1: Pleckstrin-homology domain (PH domain):