SCOP 1.73: Protein: NS3 protease

Lineage for Protein: NS3 protease

Root: SCOP 1.73
Class b: All beta proteins [48724] (165 folds)
Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
barrel, closed; n=6, S=8; greek-key
duplication: consists of two domains of the same fold
Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families)
Family b.47.1.3: Viral proteases [50596] (4 proteins)
beta sheet in the first domain is opened rather than forms a barrel
Protein NS3 protease [50600] (3 species)

Species:

Dengue virus type 2 [TaxId:11060] [50602] (3 PDB entries)
1. Domain for 1bef:
  - Domain d1befa_: 1bef A: [26419]
2. Domains for 1df9:
  1. Domain d1df9a_: 1df9 A: [26420]
    Other proteins in same PDB: d1df9c_
  2. Domain d1df9b_: 1df9 B: [26421]
    Other proteins in same PDB: d1df9c_
3. Domain for 2fom:
  - Domain d2fomb1: 2fom B:18-167 [133884]
    complexed with NS2B peptide cofactor
    complexed with cl, gol
Human hepatitis C virus (HCV), different isolates [TaxId:11103] [50601] (14 PDB entries)
1. Domains for 1a1q:
  1. Domain d1a1qa_: 1a1q A: [26414]
  2. Domain d1a1qb_: 1a1q B: [26415]
  3. Domain d1a1qc_: 1a1q C: [26416]
    complexed with zn
2. Domains for 1a1r:
  1. Domain d1a1r.1: 1a1r A:,C: [26406]
  2. Domain d1a1r.2: 1a1r B:,D: [26407]
    complexed with zn; mutant
3. Domain for 1bt7:
  - Domain d1bt7a_: 1bt7 A: [26418]
    complexed with zn; mutant
4. Domains for 1cu1:
  1. Domain d1cu1a1: 1cu1 A:705-720,A:3-186 [26408]
    Other proteins in same PDB: d1cu1a2, d1cu1a3, d1cu1b2, d1cu1b3
  2. Domain d1cu1b1: 1cu1 B:1705-1720,B:1003-1186 [26409]
    Other proteins in same PDB: d1cu1a2, d1cu1a3, d1cu1b2, d1cu1b3
    complexed with po4, zn
5. Domains for 1dxp:
  1. Domain d1dxp.1: 1dxp A:,C: [26404]
  2. Domain d1dxp.2: 1dxp B:,D: [26405]
    complexed with gol, zn
6. Domain for 1dxw:
  - Domain d1dxwa_: 1dxw A: [26417]
    complexed with abk, zn; mutant
7. Domains for 1dy8:
  1. Domain d1dy8.1: 1dy8 A:,C: [26410]
  2. Domain d1dy8.2: 1dy8 B:,D: [26411]
    complexed with cbz, fki
8. Domains for 1dy9:
  1. Domain d1dy9.1: 1dy9 A:,C: [26400]
  2. Domain d1dy9.2: 1dy9 B:,D: [26401]
    complexed with boc, fki, zn
9. Domains for 1jxp:
  1. Domain d1jxp.1: 1jxp A:,C: [26402]
  2. Domain d1jxp.2: 1jxp B:,D: [26403]
    complexed with zn
10. Domains for 1n1l:
  1. Domain d1n1l.1: 1n1l A:,C: [91544]
  2. Domain d1n1l.2: 1n1l B:,D: [91545]
    complexed with trl, zn; mutant
11. Domains for 1ns3:
  1. Domain d1ns3.1: 1ns3 A:,C: [26412]
  2. Domain d1ns3.2: 1ns3 B:,D: [26413]
    complexed with zn; mutant
12. Domains for 1rgq:
  1. Domain d1rgq.1: 1rgq A:,D: [111803]
  2. Domain d1rgq.2: 1rgq B:,C: [111804]
    complexed with akp, zn
13. Domains for 1rtl:
  1. Domain d1rtl.1: 1rtl A:,C: [111934]
  2. Domain d1rtlb_: 1rtl B: [111935]
  3. Domain d1rtld_: 1rtl D: [111936]
    complexed with cpx, zn
14. Domains for 1w3c:
  1. Domain d1w3c.1: 1w3c A:,C: [114138]
  2. Domain d1w3c.2: 1w3c B:,D: [114139]
    complexed with dn1, dn2; mutant
West nile virus [TaxId:11082] [141386] (1 PDB entry)
- Domain for 2fp7:
  - Domain d2fp7b1: 2fp7 B:19-170 [133899]
    complexed with NS2B cofactor
    complexed with ndl

More info for Protein NS3 protease from b.47.1.3: Viral proteases

Timeline for Protein NS3 protease from b.47.1.3: Viral proteases:

Protein NS3 protease from b.47.1.3: Viral proteases first appeared (with stable ids) in SCOP 1.55
Protein NS3 protease from b.47.1.3: Viral proteases appears in SCOP 1.71
Protein NS3 protease from b.47.1.3: Viral proteases appears in SCOP 1.75
Protein NS3 protease from b.47.1.3: Viral proteases appears in the current release, SCOPe 2.08