Lineage for Protein: NS3 protease

  1. Root: SCOP 1.65
  2. 287094Class b: All beta proteins [48724] (126 folds)
  3. 298675Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 298676Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families) (S)
  5. 299596Family b.47.1.3: Viral proteases [50596] (4 proteins)
    beta sheet in the first domain is opened rather than forms a barrel
  6. 299597Protein NS3 protease [50600] (2 species)

Species:

  1. 299598Dengue virus serotype 2 [50602] (2 PDB entries)
    1. Domain for 1bef:
    2. Domains for 1df9:
      1. 299600Domain d1df9a_: 1df9 A: [26420]
        Other proteins in same PDB: d1df9c_
      2. 299601Domain d1df9b_: 1df9 B: [26421]
        Other proteins in same PDB: d1df9c_
  2. 299602Human hepatitis C virus (HCV), different isolates [TaxId:11103] [50601] (10 PDB entries)
    1. Domains for 1a1q:
      1. 299617Domain d1a1qa_: 1a1q A: [26414]
      2. 299618Domain d1a1qb_: 1a1q B: [26415]
      3. 299619Domain d1a1qc_: 1a1q C: [26416]
        complexed with zn
    2. Domains for 1a1r:
      1. 299607Domain d1a1r.1: 1a1r A:,C: [26406]
      2. 299608Domain d1a1r.2: 1a1r B:,D: [26407]
        complexed with zn; mutant
    3. Domain for 1bt7:
    4. Domains for 1cu1:
      1. 299611Domain d1cu1a1: 1cu1 A:705-720,A:3-186 [26408]
        Other proteins in same PDB: d1cu1a2, d1cu1a3, d1cu1b2, d1cu1b3
      2. 299612Domain d1cu1b1: 1cu1 B:1705-1720,B:1003-1186 [26409]
        Other proteins in same PDB: d1cu1a2, d1cu1a3, d1cu1b2, d1cu1b3
        complexed with po4, zn
    5. Domains for 1dxp:
      1. 299609Domain d1dxp.1: 1dxp A:,C: [26404]
      2. 299610Domain d1dxp.2: 1dxp B:,D: [26405]
        complexed with gol, zn
    6. Domain for 1dxw:
    7. Domains for 1dy8:
      1. 299613Domain d1dy8.1: 1dy8 A:,C: [26410]
      2. 299614Domain d1dy8.2: 1dy8 B:,D: [26411]
        complexed with cbz, fki
    8. Domains for 1dy9:
      1. 299603Domain d1dy9.1: 1dy9 A:,C: [26400]
      2. 299604Domain d1dy9.2: 1dy9 B:,D: [26401]
        complexed with boc, fki, zn
    9. Domains for 1jxp:
      1. 299605Domain d1jxp.1: 1jxp A:,C: [26402]
      2. 299606Domain d1jxp.2: 1jxp B:,D: [26403]
        complexed with zn
    10. Domains for 1ns3:
      1. 299615Domain d1ns3.1: 1ns3 A:,C: [26412]
      2. 299616Domain d1ns3.2: 1ns3 B:,D: [26413]
        complexed with zn; mutant

More info for Protein NS3 protease from b.47.1.3: Viral proteases

Timeline for Protein NS3 protease from b.47.1.3: Viral proteases: