Lineage for Protein: NS3 protease

  1. Root: SCOP 1.63
  2. 218896Class b: All beta proteins [48724] (119 folds)
  3. 230291Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 230292Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families) (S)
  5. 231168Family b.47.1.3: Viral proteases [50596] (4 proteins)
    beta sheet in the first domain is opened rather than forms a barrel
  6. 231169Protein NS3 protease [50600] (2 species)

Species:

  1. 231170Dengue virus serotype 2 [50602] (2 PDB entries)
    1. Domain for 1bef:
    2. Domains for 1df9:
      1. 231172Domain d1df9a_: 1df9 A: [26420]
        Other proteins in same PDB: d1df9c_
      2. 231173Domain d1df9b_: 1df9 B: [26421]
        Other proteins in same PDB: d1df9c_
  2. 231174Human hepatitis C virus (HCV), different isolates [TaxId:11103] [50601] (10 PDB entries)
    1. Domains for 1a1q:
      1. 231189Domain d1a1qa_: 1a1q A: [26414]
      2. 231190Domain d1a1qb_: 1a1q B: [26415]
      3. 231191Domain d1a1qc_: 1a1q C: [26416]
        complexed with zn
    2. Domains for 1a1r:
      1. 231179Domain d1a1r.1: 1a1r A:,C: [26406]
      2. 231180Domain d1a1r.2: 1a1r B:,D: [26407]
        complexed with zn; mutant
    3. Domain for 1bt7:
    4. Domains for 1cu1:
      1. 231183Domain d1cu1a1: 1cu1 A:705-720,A:3-186 [26408]
        Other proteins in same PDB: d1cu1a2, d1cu1a3, d1cu1b2, d1cu1b3
      2. 231184Domain d1cu1b1: 1cu1 B:1705-1720,B:1003-1186 [26409]
        Other proteins in same PDB: d1cu1a2, d1cu1a3, d1cu1b2, d1cu1b3
        complexed with po4, zn
    5. Domains for 1dxp:
      1. 231181Domain d1dxp.1: 1dxp A:,C: [26404]
      2. 231182Domain d1dxp.2: 1dxp B:,D: [26405]
        complexed with gol, zn
    6. Domain for 1dxw:
    7. Domains for 1dy8:
      1. 231185Domain d1dy8.1: 1dy8 A:,C: [26410]
      2. 231186Domain d1dy8.2: 1dy8 B:,D: [26411]
        complexed with cbz, fki
    8. Domains for 1dy9:
      1. 231175Domain d1dy9.1: 1dy9 A:,C: [26400]
      2. 231176Domain d1dy9.2: 1dy9 B:,D: [26401]
        complexed with boc, fki, zn
    9. Domains for 1jxp:
      1. 231177Domain d1jxp.1: 1jxp A:,C: [26402]
      2. 231178Domain d1jxp.2: 1jxp B:,D: [26403]
        complexed with zn
    10. Domains for 1ns3:
      1. 231187Domain d1ns3.1: 1ns3 A:,C: [26412]
      2. 231188Domain d1ns3.2: 1ns3 B:,D: [26413]
        complexed with zn; mutant

More info for Protein NS3 protease from b.47.1.3: Viral proteases

Timeline for Protein NS3 protease from b.47.1.3: Viral proteases: