SCOP 1.63: Family b.47.1.3: Viral proteases

Lineage for Family b.47.1.3: Viral proteases

1. Root: SCOP 1.63

2. Class b: All beta proteins [48724] (119 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families)

5. Family b.47.1.3: Viral proteases [50596] (4 proteins)
   beta sheet in the first domain is opened rather than forms a barrel

Proteins:

1. NS3 protease [50600] (2 species)

   1. Species Dengue virus serotype 2 [50602] (2 PDB entries)

   2. Species Human hepatitis C virus (HCV), different isolates [TaxId:11103] [50601] (10 PDB entries)

2. NSP4 proteinase [82128] (1 species)
   minimal fold; contains C-terminal extension

   • Species Equine arteritis virus, EAV [TaxId:11047] [82129] (1 PDB entry)

3. TEV protease (nucleat inclusion protein A, NIA) [82126] (1 species)

   • Species Tobacco etch virus, TEV [TaxId:12227] [82127] (2 PDB entries)

4. Viral capsid protein [50597] (2 species)

   1. Species Semliki forest virus [TaxId:11033] [50599] (2 PDB entries)

   2. Species Sindbis virus [TaxId:11034] [50598] (10 PDB entries)

More info for Family b.47.1.3: Viral proteases

Timeline for Family b.47.1.3: Viral proteases:

• Family b.47.1.3: Viral proteases first appeared (with stable ids) in SCOP 1.55
  
• Family b.47.1.3: Viral proteases appears in SCOP 1.61
  
• Family b.47.1.3: Viral proteases appears in SCOP 1.65
  
• Family b.47.1.3: Viral proteases appears in the current release, SCOPe 2.08