Class b: All beta proteins [48724] (178 folds) |
Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily) barrel, closed; n=6, S=8; greek-key duplication: consists of two domains of the same fold |
Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families) |
Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins) |
(alpha,gamma)-chymotrypsin(ogen) [50522] (3 species) |
Species Cow (Bos taurus) [TaxId:9913] [50523] (66 PDB entries) Uniprot P00766 |
Species Norway rat (Rattus norvegicus) [TaxId:10116] [89340] (1 PDB entry) |
Species Red fire ant (Solenopsis invicta) [TaxId:13686] [50524] (1 PDB entry) |
7S NGF protease subunits [50559] (1 species) two pairs of homologous but non-identical chains |
Species Mouse (Mus musculus) [TaxId:10090] [50560] (1 PDB entry) |
Activated protein c (autoprothrombin IIa) [50579] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [50580] (3 PDB entries) |
Alpha tryptase I [89341] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [89342] (1 PDB entry) |
Beta-acrosin [50593] (2 species) |
Species Pig (Sus scrofa) [TaxId:9823] [50595] (1 PDB entry) |
Species Sheep (Ovis aries) [TaxId:9940] [50594] (1 PDB entry) |
beta-Tryptase [50546] (1 species) ring-like tetramer with active sites facing a central pore |
Species Human (Homo sapiens) [TaxId:9606] [50547] (22 PDB entries) |
Cathepsin G [50548] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [50549] (4 PDB entries) |
Chymase (mast cell protease I) [89343] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [89344] (13 PDB entries) |
Chymase II (mast cell proteinase II) [50552] (1 species) |
Species Rat (Rattus rattus) [TaxId:10117] [50553] (1 PDB entry) |
Coagulation factor IXa, protease domain [50583] (2 species) |
Species Human (Homo sapiens) [TaxId:9606] [50585] (20 PDB entries) |
Species Pig (Sus scrofa) [TaxId:9823] [50584] (2 PDB entries) |
Coagulation factor VIIa [50550] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [50551] (89 PDB entries) Uniprot P08709 213-466 ! Uniprot P08709 213-446 |
Coagulation factor Xa, protease domain [50574] (2 species) |
Species Cow (Bos taurus) [TaxId:9913] [50576] (1 PDB entry) |
Species Human (Homo sapiens) [TaxId:9606] [50575] (57 PDB entries) Uniprot P00742 235-467 |
Coagulation factor Xa-trypsin chimera [50577] (1 species) |
Species Synthetic, based on Homo sapiens sequence [50578] (1 PDB entry) Xa: residues 16-121; trypsin: residues 122-246 |
Coagulation factor XI [117237] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [117238] (58 PDB entries) Uniprot P03951 388-624 |
Complement C1R protease, catalytic domain [74976] (1 species) |
Complement C1S protease, catalytic domain [63789] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [63790] (1 PDB entry) |
Crab collagenase [50527] (1 species) |
Species Atlantic sand fiddler crab (Uca pugilator) [TaxId:6772] [50528] (1 PDB entry) |
Duodenase [63791] (1 species) new serine protease |
Species Cow (Bos taurus) [TaxId:9913] [63792] (1 PDB entry) |
Elastase [50536] (4 species) |
Species Atlantic salmon (Salmo salar) [TaxId:8030] [50539] (1 PDB entry) |
Species Human (Homo sapiens) [TaxId:9606] [50537] (15 PDB entries) |
Species Pig (Sus scrofa) [TaxId:9823] [50538] (123 PDB entries) |
Species Worm (Eisenia fetida) [TaxId:6396] [74973] (2 PDB entries) fibrinolytic enzyme component A |
Enteropeptidase (enterokinase light chain) [50540] (1 species) |
Species Cow (Bos taurus) [TaxId:9913] [50541] (1 PDB entry) |
Factor B [50561] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [50562] (4 PDB entries) Uniprot P00751 268-764 |
Factor D [50563] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [50564] (24 PDB entries) |
Granzyme A [89345] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [89346] (2 PDB entries) |
Granzyme B [50590] (2 species) |
Species Human (Homo sapiens) [TaxId:9606] [50592] (2 PDB entries) |
Species Norway rat (Rattus norvegicus) [TaxId:10116] [50591] (1 PDB entry) |
Granzyme K [82124] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [82125] (2 PDB entries) |
Heparin binding protein, HBP [50544] (1 species) multifunctional protein (synonym: CAP37, azurocidin) |
Species Human (Homo sapiens) [TaxId:9606] [50545] (4 PDB entries) |
Hepatocyte growth factor activator, HGFA [267665] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [267750] (2 PDB entries) |
Hepatocyte growth factor, HGF [110239] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [110240] (3 PDB entries) Uniprot P14210 495-728 ! Uniprot P14210 495-722 |
Hepsin, catalytic domain [101813] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [101814] (4 PDB entries) Uniprot P05981 163-417 |
HL collagenase [50529] (1 species) |
Species Common cattle grub (Hypoderma lineatum) [TaxId:7389] [50530] (2 PDB entries) |
Kallikrein 6 [74974] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [74975] (9 PDB entries) |
Kallikrein A [50555] (1 species) |
Species Pig (Sus scrofa) [TaxId:9823] [50556] (3 PDB entries) |
Kallikrein-13 [50572] (1 species) |
Species Mouse (Mus musculus) [TaxId:10090] [50573] (1 PDB entry) |
Mannan-binding lectin serine protease 2 (MASP-2), catalytic domain [110241] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [110242] (2 PDB entries) Uniprot O00187 366-686 |
Matriptase MTSP1 [69284] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [69285] (21 PDB entries) |
Myeloblastin, PR3 [50581] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [50582] (1 PDB entry) |
Neuropsin [50525] (1 species) |
Species Mouse (Mus musculus) [TaxId:10090] [50526] (1 PDB entry) |
Plasmin(ogen), catalytic domain [50588] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [50589] (10 PDB entries) |
Procarboxypeptidase A-S6 subunit III (zymogen E) [50534] (1 species) |
Species Cow (Bos taurus) [TaxId:9913] [50535] (2 PDB entries) |
Prostate specific antigen (PSA kallikrein) [82122] (1 species) |
Species Horse (Equus caballus) [TaxId:9796] [82123] (1 PDB entry) |
Single chain tissue plasminogen activator [50567] (2 species) |
Species Human (Homo sapiens) [TaxId:9606] [50568] (1 PDB entry) |
Species Vampire bat (Desmodus rotundus) [TaxId:9430] [50569] (1 PDB entry) |
Thrombin [50531] (2 species) |
Species Human (Homo sapiens) [TaxId:9606] [50532] (171 PDB entries) Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620 |
Tonin [50557] (1 species) |
Species Rat (Rattus rattus) [TaxId:10117] [50558] (1 PDB entry) |
Trypsin(ogen) [50515] (9 species) |
Species Atlantic salmon (Salmo salar) [TaxId:8030] [50520] (11 PDB entries) |
Species Chum salmon (Oncorhynchus keta) [TaxId:8018] [82121] (1 PDB entry) |
Species Cow (Bos taurus) [TaxId:9913] [50516] (494 PDB entries) Uniprot P00760 |
Species Fungus (Fusarium oxysporum) [TaxId:5507] [50521] (16 PDB entries) |
Species Human (Homo sapiens) [TaxId:9606] [50519] (4 PDB entries) |
Species Human (Homo sapiens), trypsin IV (brain isoform) [TaxId:9606] [69283] (15 PDB entries) |
Species Narrow-clawed crayfish (Pontastacus leptodactylus) [TaxId:6717] [141385] (2 PDB entries) Uniprot Q52V24 1-237 |
Species Norway rat (Rattus norvegicus) [TaxId:10116] [50518] (37 PDB entries) |
Species Pig (Sus scrofa) [TaxId:9823] [50517] (34 PDB entries) Uniprot P00761 9-231 ! Uniprot P00761 |
Two-chain tissue plasminogen activator (TC)-T-PA [50565] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [50566] (2 PDB entries) |
Urokinase [50542] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [50543] (1 PDB entry) |
Urokinase-type plasminogen activator (LMW U-PA), catalytic domain [50586] (1 species) |
Species Human (Homo sapiens) [TaxId:9606] [50587] (88 PDB entries) Uniprot P00749 156-178,179-424 |
Venom serine protease [50570] (2 species) |
Species Chinese green tree viper (Trimeresurus stejnegeri) [TaxId:39682] [50571] (1 PDB entry) |
Species Hundred-pace snake (Agkistrodon acutus) [TaxId:36307] [110238] (2 PDB entries) Uniprot Q9I8X1 |
automated matches [190044] (14 species) not a true protein |
Species Agkistrodon contortrix [TaxId:8713] [187405] (2 PDB entries) |
Species Atlantic cod (Gadus morhua) [TaxId:8049] [188345] (1 PDB entry) |
Species Chum salmon (Oncorhynchus keta) [TaxId:8018] [189036] (3 PDB entries) |
Species Cow (Bos taurus) [TaxId:9913] [187001] (23 PDB entries) |
Species Daboia russellii [TaxId:343250] [196182] (3 PDB entries) |
Species Gloydius saxatilis [TaxId:92067] [195310] (1 PDB entry) |
Species Golden hamster (Mesocricetus auratus) [TaxId:10036] [188254] (1 PDB entry) |
Species Halys viper (Agkistrodon halys) [TaxId:8714] [195671] (1 PDB entry) |
Species Human (Homo sapiens) [TaxId:9606] [187233] (166 PDB entries) |
Species Jararacussu (Bothrops jararacussu) [TaxId:8726] [194232] (1 PDB entry) |
Species Macaca mulatta [TaxId:9541] [196009] (1 PDB entry) |
Species Mouse (Mus musculus) [TaxId:10090] [188816] (5 PDB entries) |
Species Oryzias latipes [TaxId:8090] [237103] (1 PDB entry) |
Species Pig (Sus scrofa) [TaxId:9823] [193403] (1 PDB entry) |
Timeline for Family b.47.1.2: Eukaryotic proteases: