SCOP 1.69: Family b.47.1.2: Eukaryotic proteases

Lineage for Family b.47.1.2: Eukaryotic proteases

1. Root: SCOP 1.69

2. Class b: All beta proteins [48724] (144 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (4 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (46 proteins)

Proteins:

1. (alpha,gamma)-chymotrypsin(ogen) [50522] (3 species)

   1. Species Cow (Bos taurus) [TaxId:9913] [50523] (51 PDB entries)

   2. Species Rat (Rattus norvegicus) [TaxId:10116] [89340] (1 PDB entry)

   3. Species Red fire ant (Solenopsis invicta) [TaxId:13686] [50524] (1 PDB entry)

2. 7S NGF protease subunits [50559] (1 species)
   two pairs of homologous but non-identical chains

   • Species Mouse (Mus musculus) [TaxId:10090] [50560] (1 PDB entry)

3. Activated protein c (autoprothrombin IIa) [50579] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [50580] (1 PDB entry)

4. Alpha tryptase I [89341] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [89342] (1 PDB entry)

5. Beta-acrosin [50593] (2 species)

   1. Species Pig (Sus scrofa) [TaxId:9823] [50595] (1 PDB entry)

   2. Species Sheep (Ovis aries) [TaxId:9940] [50594] (1 PDB entry)

6. beta-Tryptase [50546] (1 species)
   ring-like tetramer with active sites facing a central pore

   • Species Human (Homo sapiens) [TaxId:9606] [50547] (1 PDB entry)

7. Cathepsin G [50548] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [50549] (3 PDB entries)

8. Chymase (mast cell protease I) [89343] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [89344] (1 PDB entry)

9. Chymase II (mast cell proteinase II) [50552] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [50554] (2 PDB entries)

   2. Species Rat (Rattus rattus) [TaxId:10117] [50553] (1 PDB entry)

10. Coagulation factor IXa, protease domain [50583] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [50585] (1 PDB entry)

    2. Species Pig (Sus scrofa) [TaxId:9823] [50584] (1 PDB entry)

11. Coagulation factor VIIa [50550] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50551] (10 PDB entries)

12. Coagulation factor Xa, protease domain [50574] (2 species)

    1. Species Cow (Bos taurus) [TaxId:9913] [50576] (1 PDB entry)

    2. Species Human (Homo sapiens) [TaxId:9606] [50575] (35 PDB entries)

13. Coagulation factor Xa-trypsin chimera [50577] (1 species)

    • Species Synthetic, based on Homo sapiens sequence [50578] (1 PDB entry)
      Xa: residues 16-121; trypsin: residues 122-246

14. Complement C1R protease, catalytic domain [74976] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [74977] (3 PDB entries)

15. Complement C1S protease, catalytic domain [63789] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [63790] (1 PDB entry)

16. Crab collagenase [50527] (1 species)

    • Species Atlantic sand fiddler crab (Uca pugilator) [TaxId:6772] [50528] (1 PDB entry)

17. Duodenase [63791] (1 species)
    new serine protease

    • Species Cow (Bos taurus) [TaxId:9913] [63792] (1 PDB entry)

18. Elastase [50536] (4 species)

    1. Species Earthworm (Eisenia fetida) [74973] (1 PDB entry)
       fibrinolytic enzyme component A

    2. Species Human (Homo sapiens) [TaxId:9606] [50537] (5 PDB entries)

    3. Species Pig (Sus scrofa) [TaxId:9823] [50538] (59 PDB entries)

    4. Species Salmon (Salmo salar) [TaxId:8030] [50539] (1 PDB entry)

19. Enteropeptidase (enterokinase light chain) [50540] (1 species)

    • Species Cow (Bos taurus) [TaxId:9913] [50541] (1 PDB entry)

20. Factor B [50561] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50562] (1 PDB entry)

21. Factor D [50563] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50564] (7 PDB entries)

22. Granzyme A [89345] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [89346] (2 PDB entries)

23. Granzyme B [50590] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [50592] (2 PDB entries)

    2. Species Rat (Rattus norvegicus) [TaxId:10116] [50591] (1 PDB entry)

24. Granzyme K [82124] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [82125] (2 PDB entries)

25. Heparin binding protein, HBP [50544] (1 species)
    multifunctional protein (synonym: CAP37, azurocidin)

    • Species Human (Homo sapiens) [TaxId:9606] [50545] (4 PDB entries)

26. Hepatocyte growth factor, HGF [110239] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [110240] (1 PDB entry)

27. Hepsin, catalytic domain [101813] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101814] (3 PDB entries)

28. HL collagenase [50529] (1 species)

    • Species Common cattle grub (Hypoderma lineatum) [TaxId:7389] [50530] (2 PDB entries)

29. Kallikrein 6 [74974] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [74975] (3 PDB entries)

30. Kallikrein A [50555] (1 species)

    • Species Pig (Sus scrofa) [TaxId:9823] [50556] (3 PDB entries)

31. Kallikrein-13 [50572] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [50573] (1 PDB entry)

32. Mannan-binding lectin serine protease 2 (MASP-2), catalytic domain [110241] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [110242] (1 PDB entry)

33. Matriptase MTSP1 [69284] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [69285] (2 PDB entries)

34. Myeloblastin, PR3 [50581] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50582] (1 PDB entry)

35. Neuropsin [50525] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [50526] (1 PDB entry)

36. Plasmin(ogen), catalytic domain [50588] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50589] (7 PDB entries)

37. Procarboxypeptidase A-S6 subunit III (zymogen E) [50534] (1 species)

    • Species Cow (Bos taurus) [TaxId:9913] [50535] (2 PDB entries)

38. Prostate specific antigen (PSA kallikrein) [82122] (1 species)

    • Species Horse (Equus caballus) [TaxId:9796] [82123] (1 PDB entry)

39. Single chain tissue plasminogen activator [50567] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [50568] (1 PDB entry)

    2. Species Vampire bat (Desmodus rotundus) [TaxId:9430] [50569] (1 PDB entry)

40. Thrombin [50531] (2 species)

    1. Species Cow (Bos taurus) [TaxId:9913] [50533] (26 PDB entries)

    2. Species Human (Homo sapiens) [TaxId:9606] [50532] (155 PDB entries)

41. Tonin [50557] (1 species)

    • Species Rat (Rattus rattus) [TaxId:10117] [50558] (1 PDB entry)

42. Trypsin(ogen) [50515] (8 species)

    1. Species Cow (Bos taurus) [TaxId:9913] [50516] (229 PDB entries)

    2. Species Human (Homo sapiens) [TaxId:9606] [50519] (1 PDB entry)

    3. Species Human (Homo sapiens), trypsin IV (brain isoform) [TaxId:9606] [69283] (1 PDB entry)

    4. Species Mold (Fusarium oxysporum) [TaxId:5507] [50521] (12 PDB entries)

    5. Species North atlantic salmon (Salmo salar) [TaxId:8030] [50520] (11 PDB entries)

    6. Species Pacific chum salmon (Oncorhynchus keta) [TaxId:8018] [82121] (1 PDB entry)

    7. Species Pig (Sus scrofa) [TaxId:9823] [50517] (17 PDB entries)

    8. Species Rat (Rattus norvegicus) [TaxId:10116] [50518] (30 PDB entries)

43. Two-chain tissue plasminogen activator (TC)-T-PA [50565] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50566] (2 PDB entries)

44. Urokinase [50542] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50543] (1 PDB entry)

45. Urokinase-type plasminogen activator (LMW U-PA), catalytic domain [50586] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [50587] (35 PDB entries)

46. Venom serine protease [50570] (2 species)

    1. Species Chinese green tree viper (Trimeresurus stejnejeri) [50571] (1 PDB entry)

    2. Species Hundred-pace snake (Agkistrodon acutus) [TaxId:36307] [110238] (2 PDB entries)

More info for Family b.47.1.2: Eukaryotic proteases

Timeline for Family b.47.1.2: Eukaryotic proteases:

• Family b.47.1.2: Eukaryotic proteases first appeared (with stable ids) in SCOP 1.55
  
• Family b.47.1.2: Eukaryotic proteases appears in SCOP 1.67
  
• Family b.47.1.2: Eukaryotic proteases appears in SCOP 1.71
  
• Family b.47.1.2: Eukaryotic proteases appears in the current release, SCOPe 2.08