Lineage for Family b.47.1.2: Eukaryotic proteases

  1. Root: SCOPe 2.07
  2. 2344607Class b: All beta proteins [48724] (178 folds)
  3. 2387558Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
    barrel, closed; n=6, S=8; greek-key
    duplication: consists of two domains of the same fold
  4. 2387559Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families) (S)
  5. 2387819Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

Proteins:

  1. 2387820(alpha,gamma)-chymotrypsin(ogen) [50522] (3 species)
    1. 2387821Species Cow (Bos taurus) [TaxId:9913] [50523] (60 PDB entries)
      Uniprot P00766
    2. 2387910Species Norway rat (Rattus norvegicus) [TaxId:10116] [89340] (1 PDB entry)
    3. 2387912Species Red fire ant (Solenopsis invicta) [TaxId:13686] [50524] (1 PDB entry)
  2. 23879157S NGF protease subunits [50559] (1 species)
    two pairs of homologous but non-identical chains
  3. 2387921Activated protein c (autoprothrombin IIa) [50579] (1 species)
  4. 2387925Alpha tryptase I [89341] (1 species)
  5. 2387931Beta-acrosin [50593] (2 species)
    1. 2387932Species Pig (Sus scrofa) [TaxId:9823] [50595] (1 PDB entry)
    2. 2387934Species Sheep (Ovis aries) [TaxId:9940] [50594] (1 PDB entry)
  6. 2387936beta-Tryptase [50546] (1 species)
    ring-like tetramer with active sites facing a central pore
  7. 2388006Cathepsin G [50548] (1 species)
  8. 2388012Chymase (mast cell protease I) [89343] (1 species)
  9. 2388025Chymase II (mast cell proteinase II) [50552] (1 species)
  10. 2388029Coagulation factor IXa, protease domain [50583] (2 species)
    1. 2388030Species Human (Homo sapiens) [TaxId:9606] [50585] (16 PDB entries)
    2. 2388048Species Pig (Sus scrofa) [TaxId:9823] [50584] (2 PDB entries)
  11. 2388051Coagulation factor VIIa [50550] (1 species)
  12. 2388142Coagulation factor Xa, protease domain [50574] (2 species)
    1. 2388143Species Cow (Bos taurus) [TaxId:9913] [50576] (1 PDB entry)
    2. 2388145Species Human (Homo sapiens) [TaxId:9606] [50575] (57 PDB entries)
      Uniprot P00742 235-467
  13. 2388208Coagulation factor Xa-trypsin chimera [50577] (1 species)
  14. 2388211Coagulation factor XI [117237] (1 species)
  15. Complement C1R protease, catalytic domain [74976] (1 species)
  16. 2388268Complement C1S protease, catalytic domain [63789] (1 species)
  17. 2388271Crab collagenase [50527] (1 species)
  18. 2388275Duodenase [63791] (1 species)
    new serine protease
  19. 2388278Elastase [50536] (4 species)
    1. 2388279Species Atlantic salmon (Salmo salar) [TaxId:8030] [50539] (1 PDB entry)
    2. 2388281Species Human (Homo sapiens) [TaxId:9606] [50537] (13 PDB entries)
    3. 2388296Species Pig (Sus scrofa) [TaxId:9823] [50538] (118 PDB entries)
    4. 2388417Species Worm (Eisenia fetida) [TaxId:6396] [74973] (2 PDB entries)
      fibrinolytic enzyme component A
  20. 2388424Enteropeptidase (enterokinase light chain) [50540] (1 species)
  21. 2388427Factor B [50561] (1 species)
  22. 2388434Factor D [50563] (1 species)
  23. 2388471Granzyme A [89345] (1 species)
  24. 2388480Granzyme B [50590] (2 species)
    1. 2388481Species Human (Homo sapiens) [TaxId:9606] [50592] (2 PDB entries)
    2. 2388485Species Norway rat (Rattus norvegicus) [TaxId:10116] [50591] (1 PDB entry)
  25. 2388488Granzyme K [82124] (1 species)
  26. 2388492Heparin binding protein, HBP [50544] (1 species)
    multifunctional protein (synonym: CAP37, azurocidin)
  27. 2388498Hepatocyte growth factor activator, HGFA [267665] (1 species)
  28. 2388503Hepatocyte growth factor, HGF [110239] (1 species)
  29. 2388507Hepsin, catalytic domain [101813] (1 species)
  30. 2388513HL collagenase [50529] (1 species)
  31. 2388519Kallikrein 6 [74974] (1 species)
  32. 2388524Kallikrein A [50555] (1 species)
  33. 2388531Kallikrein-13 [50572] (1 species)
  34. 2388535Mannan-binding lectin serine protease 2 (MASP-2), catalytic domain [110241] (1 species)
  35. 2388540Matriptase MTSP1 [69284] (1 species)
  36. 2388563Myeloblastin, PR3 [50581] (1 species)
  37. 2388569Neuropsin [50525] (1 species)
  38. 2388573Plasmin(ogen), catalytic domain [50588] (1 species)
  39. 2388594Procarboxypeptidase A-S6 subunit III (zymogen E) [50534] (1 species)
  40. 2388599Prostate specific antigen (PSA kallikrein) [82122] (1 species)
  41. 2388602Single chain tissue plasminogen activator [50567] (2 species)
    1. 2388603Species Human (Homo sapiens) [TaxId:9606] [50568] (1 PDB entry)
    2. 2388606Species Vampire bat (Desmodus rotundus) [TaxId:9430] [50569] (1 PDB entry)
  42. 2388608Thrombin [50531] (2 species)
    1. Species Cow (Bos taurus) [TaxId:9913] [50533] (19 PDB entries)
      Uniprot P00734 333-622
    2. 2388644Species Human (Homo sapiens) [TaxId:9606] [50532] (170 PDB entries)
      Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620
  43. 2388840Tonin [50557] (1 species)
  44. 2388843Trypsin(ogen) [50515] (9 species)
    1. 2388844Species Atlantic salmon (Salmo salar) [TaxId:8030] [50520] (11 PDB entries)
    2. 2388859Species Chum salmon (Oncorhynchus keta) [TaxId:8018] [82121] (1 PDB entry)
    3. 2388861Species Cow (Bos taurus) [TaxId:9913] [50516] (442 PDB entries)
      Uniprot P00760
    4. 2389299Species Fungus (Fusarium oxysporum) [TaxId:5507] [50521] (16 PDB entries)
    5. 2389316Species Human (Homo sapiens) [TaxId:9606] [50519] (4 PDB entries)
    6. 2389325Species Human (Homo sapiens), trypsin IV (brain isoform) [TaxId:9606] [69283] (13 PDB entries)
    7. 2389354Species Narrow-clawed crayfish (Pontastacus leptodactylus) [TaxId:6717] [141385] (2 PDB entries)
      Uniprot Q52V24 1-237
    8. 2389358Species Norway rat (Rattus norvegicus) [TaxId:10116] [50518] (37 PDB entries)
    9. 2389400Species Pig (Sus scrofa) [TaxId:9823] [50517] (34 PDB entries)
      Uniprot P00761 9-231 ! Uniprot P00761
  45. 2389440Two-chain tissue plasminogen activator (TC)-T-PA [50565] (1 species)
  46. 2389445Urokinase [50542] (1 species)
  47. 2389448Urokinase-type plasminogen activator (LMW U-PA), catalytic domain [50586] (1 species)
  48. 2389535Venom serine protease [50570] (2 species)
    1. 2389536Species Chinese green tree viper (Trimeresurus stejnegeri) [TaxId:39682] [50571] (1 PDB entry)
    2. 2389539Species Hundred-pace snake (Agkistrodon acutus) [TaxId:36307] [110238] (2 PDB entries)
      Uniprot Q9I8X1
  49. 2389542automated matches [190044] (14 species)
    not a true protein
    1. 2389543Species Agkistrodon contortrix [TaxId:8713] [187405] (2 PDB entries)
    2. 2389546Species Atlantic cod (Gadus morhua) [TaxId:8049] [188345] (1 PDB entry)
    3. 2389548Species Chum salmon (Oncorhynchus keta) [TaxId:8018] [189036] (3 PDB entries)
    4. 2389554Species Cow (Bos taurus) [TaxId:9913] [187001] (14 PDB entries)
    5. 2389572Species Daboia russellii [TaxId:343250] [196182] (3 PDB entries)
    6. 2389576Species Gloydius saxatilis [TaxId:92067] [195310] (1 PDB entry)
    7. 2389578Species Golden hamster (Mesocricetus auratus) [TaxId:10036] [188254] (1 PDB entry)
    8. 2389581Species Halys viper (Agkistrodon halys) [TaxId:8714] [195671] (1 PDB entry)
    9. 2389583Species Human (Homo sapiens) [TaxId:9606] [187233] (146 PDB entries)
    10. 2389746Species Jararacussu (Bothrops jararacussu) [TaxId:8726] [194232] (1 PDB entry)
    11. 2389748Species Macaca mulatta [TaxId:9541] [196009] (1 PDB entry)
    12. 2389751Species Mouse (Mus musculus) [TaxId:10090] [188816] (4 PDB entries)
    13. 2389762Species Oryzias latipes [TaxId:8090] [237103] (1 PDB entry)
    14. 2389765Species Pig (Sus scrofa) [TaxId:9823] [193403] (1 PDB entry)

More info for Family b.47.1.2: Eukaryotic proteases

Timeline for Family b.47.1.2: Eukaryotic proteases: