SCOPe 2.06: Family b.36.1.1: PDZ domain

Lineage for Family b.36.1.1: PDZ domain

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.36: PDZ domain-like [50155] (1 superfamily)
   contains barrel, partly opened; n*=4, S*=8; meander; capped by alpha-helix

4. Superfamily b.36.1: PDZ domain-like [50156] (7 families)
   peptide-binding domain

5. Family b.36.1.1: PDZ domain [50157] (47 proteins)
   Pfam PF00595

Proteins:

1. Afadin [141269] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [141270] (2 PDB entries)
     Uniprot P55196 985-1079! Uniprot P55196 987-1077

2. Alpha-actinin-2 associated LIM protein [110178] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [110179] (1 PDB entry)
     Uniprot O70209 4-93

3. Amyloid beta A4 precursor protein-binding family A member 1 (APBA1, X11) [141282] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [141283] (6 PDB entries)
     Uniprot Q02410 656-740! Uniprot Q02410 657-743! Uniprot Q02410 657-745! Uniprot Q02410 743-822! Uniprot Q02410 745-823! Uniprot Q02410 746-839
     structure of the PTB domain is also known (50757)

4. Cask/Lin-2 [50160] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [50161] (1 PDB entry)

5. Channel associated protein of synapse-110 [141273] (1 species)
   Discs large homolog 2, PSD-93

   • Species Human (Homo sapiens) [TaxId:9606] [141274] (1 PDB entry)
     Uniprot Q15700 190-283

6. Discs large 5 protein KIAA0583 [101725] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [101726] (1 PDB entry)

7. Discs large protein homolog [50158] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [50159] (2 PDB entries)

8. DNA Regulating synaptic membrane exocytosis protein 2, RIMS2 [117176] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [117177] (1 PDB entry)
     Uniprot Q9UQ26 637-754; the structure of the 1st C2 domain (807-934) is also known (101565)

9. Enigma homolog ENH [117174] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [117175] (1 PDB entry)
     Uniprot Q8CI51 5-94

10. Erbin [82085] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [82086] (4 PDB entries)

11. Glutamate receptor interacting protein [82083] (2 species)

    1. Species Mouse (Mus musculus) [TaxId:10090] [110177] (1 PDB entry)
       Uniprot Q925T6 461-570

    2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [82084] (3 PDB entries)

12. Glutamate receptor interacting protein 2, GRIP2 (KIAA1719) [110180] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [110181] (2 PDB entries)
      Uniprot Q9C0E4 238-341

13. Glutamate receptor-interacting protein 1, GRIP1 [101717] (1 species)

    • Species Norway rat (Rattus norvegicus) [TaxId:10116] [101718] (2 PDB entries)

14. GTPase-binding domain of the cell polarity protein par6 (Par-6B) [89315] (2 species)

    1. Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [101716] (3 PDB entries)
       Uniprot O97111 156-253; Cg5884-pa

    2. Species Mouse (Mus musculus) [TaxId:10090] [89316] (1 PDB entry)

15. Harmonin [110182] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [141263] (1 PDB entry)
       Uniprot Q9Y6N9 201-301

    2. Species Mouse (Mus musculus) [TaxId:10090] [110183] (1 PDB entry)
       Uniprot Q9ES64 741-850

16. hypothetical PDZ domain containing protein Uqcrc2 (4930408O21Rik) [117184] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [117185] (1 PDB entry)
      Uniprot Q9CR71 8-120

17. Hypothetical protein KIAA0559 [101727] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101728] (1 PDB entry)

18. Hypothetical protein KIAA1095 [101723] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101724] (2 PDB entries)
      Uniprot Q9UPQ7 246-339, 404-512

19. Hypothetical protein KIAA1849 [101729] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101730] (1 PDB entry)

20. Inad [63756] (1 species)

    • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [63757] (1 PDB entry)

21. KIAA1526 protein [101721] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101722] (3 PDB entries)

22. Maguk p55 subfamily member 5 [141275] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [141276] (1 PDB entry)
      Uniprot Q9JLB2 236-335
      Structure of the second L27 domain is known (101293)

23. Membrane associated guanylate kinase inverted-2 (MAGI-2, KIAA0705) [101719] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101720] (5 PDB entries)
      Uniprot Q86UL8 412-522, 600-682, 774-865, 913-1015, 1141-1230

24. Multiple PDZ domain protein [141267] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141268] (4 PDB entries)
      Uniprot Q5VZ62 1138-1243! Uniprot Q5VZ62 1955-2042

25. Na+/H+ exchanger regulatory factor, NHERF [63754] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [63755] (4 PDB entries)

26. Neurabin-i [141277] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141278] (1 PDB entry)
      Uniprot Q9ULJ8 500-593

27. Neuronal nitric oxide synthase, NNOS [50166] (1 species)

    • Species Norway rat (Rattus norvegicus) [TaxId:10116] [50167] (3 PDB entries)

28. Partitioning-defective 3-like protein, PAR3-L (RIKEN cDNA 2810455b10) [117178] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [117179] (1 PDB entry)
      Uniprot Q5SV53 478-591

29. PDZ domain containing protein 11, Pdzk11 [117182] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [117183] (1 PDB entry)
      Uniprot Q9CZG9 37-127

30. PDZ-LIM protein mystique [110186] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [110187] (1 PDB entry)
      Uniprot Q8R1G6 3-83

31. Phosphatase hPTP1e [50168] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [50169] (7 PDB entries)

    2. Species Mouse (Mus musculus) [TaxId:10090] [74930] (3 PDB entries)

32. Presynaptic protein sap97 [141284] (1 species)
    PSD-95 homologue

    • Species Norway rat (Rattus norvegicus) [TaxId:10116] [141285] (1 PDB entry)
      Uniprot Q62696 221-313

33. Regulating synaptic membrane exocytosis protein 1, RIMS1 [141279] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [141281] (1 PDB entry)
       Uniprot Q86UR5 585-694

    2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [141280] (1 PDB entry)
       Uniprot Q9JIR4 597-705

34. Regulator of G-protein signaling 3, RGS3 [117180] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [141264] (1 PDB entry)
       Uniprot P49796 300-376

    2. Species Mouse (Mus musculus) [TaxId:10090] [117181] (1 PDB entry)
       Uniprot Q9DC04 18-94

35. Rhophilin-2 [110184] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [110185] (1 PDB entry)
      Uniprot Q8BWR8 506-603

36. Scribble (KIAA0147) [101731] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101732] (4 PDB entries)
      Uniprot Q14160 680-951, 1096-1193 # structure of 1st PDZ domain is also known, 1XQ5

37. Segment polarity protein dishevelled homolog Dvl-2 [89313] (3 species)

    1. Species African clawed frog (Xenopus laevis) [TaxId:8355] [89314] (2 PDB entries)

    2. Species Human (Homo sapiens) [TaxId:9606] [188234] (5 PDB entries)

    3. Species Mouse (Mus musculus) [TaxId:10090] [101715] (1 PDB entry)

38. Shank1, PDZ domain [101733] (1 species)
    SH3 and multiple ankyrin repeat domains protein 1

    • Species Norway rat (Rattus norvegicus) [TaxId:10116] [101734] (5 PDB entries)

39. Synapse-associated protein 102 [101713] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101714] (2 PDB entries)

40. Synaptic protein PSD-95 [50162] (2 species)
    Synonym: synapse associated protein 90, sap90
    duplication: contains three PDZ domains

    1. Species Human (Homo sapiens) [TaxId:9606] [74932] (1 PDB entry)

    2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [50163] (12 PDB entries)
       Uniprot P31016 62-154

41. Syntaxin binding protein 4 [141271] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [141272] (1 PDB entry)
      Uniprot Q9WV89 12-107

42. Syntenin 1 [89311] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [89312] (11 PDB entries)

43. Syntrophin [50164] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [50165] (2 PDB entries)

44. Tight junction protein ZO-2, Tjp2 [141265] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [141266] (1 PDB entry)
      Uniprot Q9Z0U1 1-104

45. Tyrosine-protein phosphatase non-receptor type 4, PTPN4 [141286] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141287] (3 PDB entries)
      Uniprot P29074 507-612

46. Zasp (Cypher, Oracle 1) [101735] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [101736] (1 PDB entry)

    2. Species Mouse (Mus musculus) [TaxId:10090] [117173] (1 PDB entry)
       Uniprot Q9D130 1-83

47. automated matches [190055] (7 species)
    not a true protein

    1. Species African clawed frog (Xenopus laevis) [TaxId:8355] [187076] (1 PDB entry)

    2. Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [255425] (2 PDB entries)

    3. Species Homo sapiens [TaxId:9606] [326414] (3 PDB entries)

    4. Species Homo sapiens, influenza a virus [TaxId:9606] [193650] (1 PDB entry)

    5. Species Human (Homo sapiens) [TaxId:9606] [187785] (40 PDB entries)

    6. Species Mouse (Mus musculus) [TaxId:10090] [189198] (6 PDB entries)

    7. Species Norway rat (Rattus norvegicus) [TaxId:10116] [186775] (11 PDB entries)

More info for Family b.36.1.1: PDZ domain

Timeline for Family b.36.1.1: PDZ domain:

• Family b.36.1.1: PDZ domain first appeared (with stable ids) in SCOP 1.55
  
• Family b.36.1.1: PDZ domain appears in SCOPe 2.05
  
• Family b.36.1.1: PDZ domain appears in SCOPe 2.07
  
• Family b.36.1.1: PDZ domain appears in the current release, SCOPe 2.08