SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family b.36.1.1: PDZ domain

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2048292Fold b.36: PDZ domain-like [50155] (1 superfamily)
    contains barrel, partly opened; n*=4, S*=8; meander; capped by alpha-helix
  4. 2048293Superfamily b.36.1: PDZ domain-like [50156] (7 families) (S)
    peptide-binding domain
  5. 2048294Family b.36.1.1: PDZ domain [50157] (47 protein domains)
    Pfam PF00595

Protein Domains:

  1. 2048295Afadin [141269] (1 species)
  2. 2048299Alpha-actinin-2 associated LIM protein [110178] (1 species)
  3. 2048302Amyloid beta A4 precursor protein-binding family A member 1 (APBA1, X11) [141282] (1 species)
  4. 2048311Cask/Lin-2 [50160] (1 species)
  5. 2048315Channel associated protein of synapse-110 [141273] (1 species)
    Discs large homolog 2, PSD-93
  6. 2048318Discs large 5 protein KIAA0583 [101725] (1 species)
  7. 2048321Discs large protein homolog [50158] (1 species)
  8. 2048327DNA Regulating synaptic membrane exocytosis protein 2, RIMS2 [117176] (1 species)
  9. 2048330Enigma homolog ENH [117174] (1 species)
  10. 2048333Erbin [82085] (1 species)
  11. 2048340Glutamate receptor interacting protein [82083] (2 species)
    1. 2048341Species Mouse (Mus musculus) [TaxId:10090] [110177] (1 PDB entry)
      Uniprot Q925T6 461-570
    2. 2048343Species Norway rat (Rattus norvegicus) [TaxId:10116] [82084] (3 PDB entries)
  12. 2048348Glutamate receptor interacting protein 2, GRIP2 (KIAA1719) [110180] (1 species)
  13. 2048352Glutamate receptor-interacting protein 1, GRIP1 [101717] (1 species)
  14. 2048357GTPase-binding domain of the cell polarity protein par6 (Par-6B) [89315] (2 species)
    1. 2048358Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [101716] (3 PDB entries)
      Uniprot O97111 156-253; Cg5884-pa
    2. 2048362Species Mouse (Mus musculus) [TaxId:10090] [89316] (1 PDB entry)
  15. 2048365Harmonin [110182] (2 species)
    1. 2048366Species Human (Homo sapiens) [TaxId:9606] [141263] (1 PDB entry)
      Uniprot Q9Y6N9 201-301
    2. 2048368Species Mouse (Mus musculus) [TaxId:10090] [110183] (1 PDB entry)
      Uniprot Q9ES64 741-850
  16. 2048370hypothetical PDZ domain containing protein Uqcrc2 (4930408O21Rik) [117184] (1 species)
  17. 2048373Hypothetical protein KIAA0559 [101727] (1 species)
  18. 2048376Hypothetical protein KIAA1095 [101723] (1 species)
  19. 2048380Hypothetical protein KIAA1849 [101729] (1 species)
  20. 2048383Inad [63756] (1 species)
  21. 2048387KIAA1526 protein [101721] (1 species)
  22. 2048392Maguk p55 subfamily member 5 [141275] (1 species)
  23. 2048395Membrane associated guanylate kinase inverted-2 (MAGI-2, KIAA0705) [101719] (1 species)
  24. 2048402Multiple PDZ domain protein [141267] (1 species)
  25. 2048412Na+/H+ exchanger regulatory factor, NHERF [63754] (1 species)
  26. 2048418Neurabin-i [141277] (1 species)
  27. 2048421Neuronal nitric oxide synthase, NNOS [50166] (1 species)
  28. 2048426Partitioning-defective 3-like protein, PAR3-L (RIKEN cDNA 2810455b10) [117178] (1 species)
  29. 2048429PDZ domain containing protein 11, Pdzk11 [117182] (1 species)
  30. 2048432PDZ-LIM protein mystique [110186] (1 species)
  31. 2048435Phosphatase hPTP1e [50168] (2 species)
    1. 2048436Species Human (Homo sapiens) [TaxId:9606] [50169] (7 PDB entries)
    2. 2048449Species Mouse (Mus musculus) [TaxId:10090] [74930] (3 PDB entries)
  32. 2048453Presynaptic protein sap97 [141284] (1 species)
    PSD-95 homologue
  33. 2048456Regulating synaptic membrane exocytosis protein 1, RIMS1 [141279] (2 species)
    1. 2048457Species Human (Homo sapiens) [TaxId:9606] [141281] (1 PDB entry)
      Uniprot Q86UR5 585-694
    2. 2048459Species Norway rat (Rattus norvegicus) [TaxId:10116] [141280] (1 PDB entry)
      Uniprot Q9JIR4 597-705
  34. 2048461Regulator of G-protein signaling 3, RGS3 [117180] (2 species)
    1. 2048462Species Human (Homo sapiens) [TaxId:9606] [141264] (1 PDB entry)
      Uniprot P49796 300-376
    2. 2048465Species Mouse (Mus musculus) [TaxId:10090] [117181] (1 PDB entry)
      Uniprot Q9DC04 18-94
  35. 2048467Rhophilin-2 [110184] (1 species)
  36. 2048470Scribble (KIAA0147) [101731] (1 species)
  37. 2048477Segment polarity protein dishevelled homolog Dvl-2 [89313] (3 species)
    1. 2048478Species African clawed frog (Xenopus laevis) [TaxId:8355] [89314] (2 PDB entries)
    2. 2048486Species Human (Homo sapiens) [TaxId:9606] [188234] (5 PDB entries)
    3. 2048496Species Mouse (Mus musculus) [TaxId:10090] [101715] (1 PDB entry)
  38. 2048498Shank1, PDZ domain [101733] (1 species)
    SH3 and multiple ankyrin repeat domains protein 1
  39. 2048515Synapse-associated protein 102 [101713] (1 species)
  40. 2048519Synaptic protein PSD-95 [50162] (2 species)
    Synonym: synapse associated protein 90, sap90
    duplication: contains three PDZ domains
    1. 2048520Species Human (Homo sapiens) [TaxId:9606] [74932] (1 PDB entry)
    2. 2048522Species Norway rat (Rattus norvegicus) [TaxId:10116] [50163] (12 PDB entries)
      Uniprot P31016 62-154
  41. 2048531Syntaxin binding protein 4 [141271] (1 species)
  42. 2048534Syntenin 1 [89311] (1 species)
  43. 2048569Syntrophin [50164] (1 species)
  44. 2048573Tight junction protein ZO-2, Tjp2 [141265] (1 species)
  45. 2048576Tyrosine-protein phosphatase non-receptor type 4, PTPN4 [141286] (1 species)
  46. 2048585Zasp (Cypher, Oracle 1) [101735] (2 species)
    1. 2048586Species Human (Homo sapiens) [TaxId:9606] [101736] (1 PDB entry)
    2. 2048588Species Mouse (Mus musculus) [TaxId:10090] [117173] (1 PDB entry)
      Uniprot Q9D130 1-83
  47. 2048590automated matches [190055] (7 species)
    not a true protein
    1. 2048591Species African clawed frog (Xenopus laevis) [TaxId:8355] [187076] (1 PDB entry)
    2. 2048594Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [255425] (2 PDB entries)
    3. 2048597Species Homo sapiens, influenza a virus [TaxId:9606] [193650] (1 PDB entry)
    4. 2048599Species Human (Homo sapiens) [TaxId:9606] [187785] (40 PDB entries)
    5. 2048667Species Mouse (Mus musculus) [TaxId:10090] [189198] (6 PDB entries)
    6. 2048682Species Norway rat (Rattus norvegicus) [TaxId:10116] [186775] (9 PDB entries)
    7. 2283113Species Homo sapiens [TaxId:9606] [326414] (1 PDB entry)

More info for Family b.36.1.1: PDZ domain

Timeline for Family b.36.1.1: PDZ domain: