SCOP 1.75: Family b.22.1.1: TNF-like

Lineage for Family b.22.1.1: TNF-like

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.22: TNF-like [49841] (1 superfamily)
   sandwich, 10 strands in 2 sheets; jelly-roll

4. Superfamily b.22.1: TNF-like [49842] (1 family)

5. Family b.22.1.1: TNF-like [49843] (14 proteins)

Proteins:

1. 30 kDa adipocyte complement-related protein [49846] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [49847] (2 PDB entries)

2. A proliferation-inducing ligand, APRIL [117117] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [117118] (5 PDB entries)
     Uniprot Q9D777 105-251
     Uniprot Q9D777 105-241
     Uniprot Q9D777 105-251 ! Uniprot Q9D777 105-241

3. Apoptosis-2 ligand, apo2l/TRAIL [49851] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [49852] (5 PDB entries)

4. Collagen NC1 trimerisation domain [69230] (2 species)

   1. Species Human (Homo sapiens), isoform X [TaxId:9606] [69231] (1 PDB entry)

   2. Species Mouse (Mus musculus), isoform VIII [TaxId:10090] [101612] (1 PDB entry)

5. Complement c1q globular head, A chain [101613] (1 species)
   hetrotrimer of A, B and C chains

   • Species Human (Homo sapiens) [TaxId:9606] [101614] (3 PDB entries)

6. Complement c1q globular head, B chain [101615] (1 species)
   hetrotrimer of A, B and C chains

   • Species Human (Homo sapiens) [TaxId:9606] [101616] (3 PDB entries)

7. Complement c1q globular head, C chain [101617] (1 species)
   hetrotrimer of A, B and C chains

   • Species Human (Homo sapiens) [TaxId:9606] [101618] (3 PDB entries)

8. Ectodysplasin A, Eda-a1 [101610] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [101611] (2 PDB entries)

9. Extracellular domain of CD40 ligand [49844] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [49845] (2 PDB entries)

10. Glucocorticoid-induced TNF-related ligand, TNFSF18 [158982] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [158984] (5 PDB entries)
       Uniprot Q9UNG2 55-177! Uniprot Q9UNG2 57-172! Uniprot Q9UNG2 57-176

    2. Species Mouse (Mus musculus) [TaxId:10090] [158983] (3 PDB entries)
       Uniprot Q7TS55 51-173! Uniprot Q80YG2 49-173

11. Soluble part of TALL-1, sTALL-1 (BAFF) [69228] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [69229] (6 PDB entries)
      also includes the PDB entry (1otz) that together with the entry (1p0t) provides the multimeric structure of the complex of this protein with its receptor, BAFF-R. In these entries protein chains are designated by both upper case and lower case letters creating problems with its processing and presentation in SCOP
      also includes the PDB entry (1otz) that together with the entry (1p0t) provides the multimeric structure of the complex of this protein with its receptor, BAFF-R. In these entries protein chains are designated by both upper case and lower case letters creating problems with its processing and presentation in SCOP

12. TRANCE/RANKL cytokine [63721] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [63722] (3 PDB entries)

13. Tumor necrosis factor (TNF) [49848] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [49849] (7 PDB entries)

    2. Species Mouse (Mus musculus) [TaxId:10090] [49850] (1 PDB entry)

14. Tumor necrosis factor ligand superfamily member 4, OX40L [141127] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [141128] (1 PDB entry)
       Uniprot P23510 58-183

    2. Species Mouse (Mus musculus) [TaxId:10090] [141129] (2 PDB entries)
       Uniprot P43488 58-185

More info for Family b.22.1.1: TNF-like

Timeline for Family b.22.1.1: TNF-like:

• Family b.22.1.1: TNF-like first appeared (with stable ids) in SCOP 1.55
  
• Family b.22.1.1: TNF-like appears in SCOP 1.73
  
• Family b.22.1.1: TNF-like appears in SCOPe 2.01
  
• Family b.22.1.1: TNF-like appears in the current release, SCOPe 2.08