SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Family b.7.1.2: Synaptotagmin-like (S variant)

  1. Root: SCOPe 2.06
  2. 2017114Class b: All beta proteins [48724] (177 folds)
  3. 2038038Fold b.7: C2 domain-like [49561] (5 superfamilies)
    sandwich; 8 strands in 2 sheets; greek-key
  4. 2038039Superfamily b.7.1: C2 domain (Calcium/lipid-binding domain, CaLB) [49562] (3 families) (S)
    two constituent families are related by circular permutation
  5. 2038183Family b.7.1.2: Synaptotagmin-like (S variant) [49575] (11 protein domains)
    topologically similar to the C-terminal domain of PapD

Protein Domains:

  1. 2038184C2 domain from protein kinase c (alpha) [49578] (1 species)
  2. 2038192C2 domain from protein kinase c (beta) [49580] (1 species)
  3. 2038196C2 domain protein At1g63220 [117082] (1 species)
  4. C2b-domain of rabphilin [49582] (1 species)
  5. 2038202Piccolo [101566] (1 species)
  6. 2038205Regulating synaptic membrane exocytosis protein, rim2 [101564] (1 species)
  7. 2038208Synaptogamin I [49576] (3 species)
    duplication: contains tandem repeat of two similar domains
    1. 2038209Species Human (Homo sapiens) [TaxId:9606] [158946] (10 PDB entries)
    2. 2038225Species Norway rat (Rattus norvegicus) [TaxId:10116] [49577] (7 PDB entries)
      Uniprot P21707 271-419 ! Uniprot P21707 271-419
    3. 2292135Species Mus musculus [TaxId:10090] [335436] (1 PDB entry)
  8. 2038233Synaptotagmin III [109606] (1 species)
    duplication: contains 2 C2 domains
  9. 2038237Synaptotagmin IV [101562] (2 species)
    duplication: contains 2 C2 domains
    1. 2038238Species Human (Homo sapiens) [TaxId:9606] [101563] (1 PDB entry)
    2. 2038240Species Norway rat (Rattus norvegicus) [TaxId:10116] [110115] (2 PDB entries)
      Uniprot P50232 288-425
  10. 2038243Synaptotagmin XIII [117084] (1 species)
  11. 2038246automated matches [190234] (3 species)
    not a true protein
    1. 2038247Species Human (Homo sapiens) [TaxId:9606] [188037] (3 PDB entries)
    2. 2038253Species Norway rat (Rattus norvegicus) [TaxId:10116] [186999] (7 PDB entries)
    3. 2292111Species Mus musculus [TaxId:10090] [335412] (1 PDB entry)

More info for Family b.7.1.2: Synaptotagmin-like (S variant)

Timeline for Family b.7.1.2: Synaptotagmin-like (S variant):