SCOPe 2.07: Family b.1.2.1: Fibronectin type III

Lineage for Family b.1.2.1: Fibronectin type III

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.2: Fibronectin type III [49265] (2 families)

5. Family b.1.2.1: Fibronectin type III [49266] (45 proteins)
   Pfam PF00041

Proteins:

1. Brother of CDO precursor (BOC) [141037] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [141038] (2 PDB entries)
     Uniprot Q6AZB0 591-689! Uniprot Q6AZB0 707-807

2. Ciliary neurotrophic factor receptor alpha [110060] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [110061] (1 PDB entry)
     Uniprot P26992 202-305

3. Common beta-chain in the GM-CSF, IL-3 and IL-5 receptors [49289] (1 species)
   duplication: consists of four similar domains; dimerizes by swapping the C-terminal strands of domains 1 and 3

   • Species Human (Homo sapiens) [TaxId:9606] [49290] (5 PDB entries)

4. Contactin 3 (KIAA1496) [117055] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [117056] (1 PDB entry)
     Uniprot Q9P232 893-996

5. Cytokine receptor common gamma chain [141041] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [141042] (6 PDB entries)
     Uniprot P31785 142-246! Uniprot P31785 142-248! Uniprot P31785 54-141! Uniprot P31785 56-141

6. Cytokine receptor gp130 cytokine-binding domains [49295] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [49296] (5 PDB entries)

7. Down syndrome cell adhesion molecule-like protein 1, DSCAML1 [141055] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [141056] (1 PDB entry)
     Uniprot Q8TD84 979-1087

8. Ephrin type-A receptor 1 [141063] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [141064] (1 PDB entry)
     Uniprot Q60750 446-539

9. Ephrin type-A receptor 8 [141039] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [141040] (1 PDB entry)
     Uniprot P29322 473-534
     structure of the C-terminal SAM domain is known (101243)

10. Ephrin type-B receptor 1 [141035] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141036] (1 PDB entry)
      Uniprot P54762 434-528

11. Erythropoietin (EPO) receptor [49282] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49283] (6 PDB entries)

12. Extracellular region of human tissue factor [49267] (2 species)
    tandem of fibronectin type III domains

    1. Species Human (Homo sapiens) [TaxId:9606] [49268] (35 PDB entries)
       Uniprot P13726 33-242

    2. Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [49269] (1 PDB entry)

13. Fibronectin type 3 and ankyrin repeat domains 1 protein, FANK1 [117053] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [117054] (1 PDB entry)
      Uniprot Q9DAM9 1-107

14. Fibronectin type III domain from chitinase A1. [81975] (1 species)

    • Species Bacillus circulans [TaxId:1397] [81976] (1 PDB entry)

15. Fibronectin type-III domain containing protein 3a, FNDC3A (KIAA0970) [117057] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [117058] (6 PDB entries)
      Uniprot Q9Y2H6 192-315

16. Fibronectin, different Fn3 modules [49270] (3 species)

    1. Species Escherichia coli K-12 [TaxId:83333] [158899] (1 PDB entry)

    2. Species Human (Homo sapiens) [TaxId:9606] [49271] (9 PDB entries)

    3. Species Mouse (Mus musculus) [TaxId:10090] [49272] (2 PDB entries)

17. Granulocyte colony-stimulating factor (GC-SF) receptor [49291] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [141034] (1 PDB entry)
       Uniprot Q99062 120-226! Uniprot Q99062 227-331

    2. Species Mouse (Mus musculus) [TaxId:10090] [49292] (4 PDB entries)

18. Growth hormone receptor [49280] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49281] (6 PDB entries)
      tandem of fibronectin type III domains

19. Hedgehog receptor iHog [141061] (1 species)
    Cg9211-PA

    • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [141062] (3 PDB entries)
      Uniprot Q9VM64 466-572! Uniprot Q9VM64 573-667

20. Host cell factor 2, HCF-2 [117051] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [117052] (1 PDB entry)
      Uniprot Q9D968 127-236

21. Insulin receptor [158901] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [158902] (1 PDB entry)
      Uniprot P06213 495-618

22. Integrin beta-4 subunit [49278] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49279] (3 PDB entries)

23. Interferon-alpha/beta receptor beta chain [89199] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [89200] (5 PDB entries)

24. Interferon-gamma receptor alpha chain [49293] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49294] (3 PDB entries)

25. Interleukin-10 receptor 1, IL-10R1 [63670] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [63671] (5 PDB entries)

26. Interleukin-2 receptor beta chain [141047] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141048] (4 PDB entries)
      Uniprot P14784 130-232! Uniprot P14784 130-233! Uniprot P14784 32-129

27. Interleukin-4 receptor alpha chain [49287] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49288] (1 PDB entry)

28. Interleukin-6 receptor alpha chain, domains 2 and 3 [81977] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [81978] (3 PDB entries)

29. KIAA0343 protein [101531] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101532] (2 PDB entries)

30. KIAA1355 [110058] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [110059] (1 PDB entry)
      Uniprot Q9P2J2 [Fragment] 634-728

31. KIAA1568 protein [101529] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101530] (2 PDB entries)

32. Myosin binding protein C, fast-type [141057] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [141058] (1 PDB entry)
      Uniprot Q5XKE0 731-828

33. Neogenin [141053] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141054] (6 PDB entries)
      Uniprot Q92859 429-535! Uniprot Q92859 529-631! Uniprot Q92859 623-741! Uniprot Q92859 718-830! Uniprot Q92859 853-952! Uniprot Q92859 942-1054

34. Neural cell adhesion molecule 1, NCAM [89197] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [141033] (4 PDB entries)
       Uniprot P13592 498-598

    2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [89198] (1 PDB entry)

35. Neuroglian, two amino proximal Fn3 repeats [49276] (1 species)
    tandem of fibronectin type III domains

    • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [49277] (1 PDB entry)

36. Prolactin receptor [49284] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [49285] (1 PDB entry)

    2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [49286] (1 PDB entry)

37. Receptor-type tyrosine-protein phosphatase delta, PTPRD [141049] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141050] (2 PDB entries)
      Uniprot P23468 504-607

38. Receptor-type tyrosine-protein phosphatase F, PTPRF [141059] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141060] (1 PDB entry)
      Uniprot P10586 811-904

39. Rim binding protein 2 [141043] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141044] (1 PDB entry)
      Uniprot O15034 477-593

40. Sidekick 2 [141051] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141052] (4 PDB entries)
      Uniprot Q58EX2 1279-1395! Uniprot Q58EX2 578-685! Uniprot Q58EX2 881-988! Uniprot Q58EX2 981-1081

41. Tenascin [49273] (3 species)

    1. Species Chicken (Gallus gallus) [TaxId:9031] [49274] (1 PDB entry)

    2. Species Human (Homo sapiens) [TaxId:9606] [49275] (1 PDB entry)

    3. Species Norway rat (Rattus norvegicus) [TaxId:10116] [110057] (1 PDB entry)
       Uniprot Q05546 502-770

42. Tenascin-X [141045] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141046] (3 PDB entries)
      Uniprot P22105 3699-3798! Uniprot P22105 3890-3991! Uniprot P22105 3977-4069

43. The p40 domain of interleukin-12 (IL-12 beta chain), domains 2 and 3 [63672] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [63673] (5 PDB entries)

44. Type I titin module [49297] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49298] (1 PDB entry)

45. automated matches [190888] (2 species)
    not a true protein

    1. Species Escherichia coli [TaxId:562] [360878] (1 PDB entry)

    2. Species Human (Homo sapiens) [TaxId:9606] [188282] (32 PDB entries)

More info for Family b.1.2.1: Fibronectin type III

Timeline for Family b.1.2.1: Fibronectin type III:

• Family b.1.2.1: Fibronectin type III first appeared (with stable ids) in SCOP 1.55
  
• Family b.1.2.1: Fibronectin type III appears in SCOPe 2.06
  
• Family b.1.2.1: Fibronectin type III appears in the current release, SCOPe 2.08