SCOP 1.73: Family b.1.2.1: Fibronectin type III

Lineage for Family b.1.2.1: Fibronectin type III

1. Root: SCOP 1.73

2. Class b: All beta proteins [48724] (165 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (27 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.2: Fibronectin type III [49265] (1 family)

5. Family b.1.2.1: Fibronectin type III [49266] (43 proteins)
   Pfam PF00041

Proteins:

1. Brother of CDO precursor (BOC) [141037] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [141038] (2 PDB entries)

2. Ciliary neurotrophic factor receptor alpha [110060] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [110061] (1 PDB entry)

3. Common beta-chain in the GM-CSF, IL-3 and IL-5 receptors [49289] (1 species)
   duplication: consists of four similar domains; dimerizes by swapping the C-terminal strands of domains 1 and 3

   • Species Human (Homo sapiens) [TaxId:9606] [49290] (4 PDB entries)

4. Contactin 3 (KIAA1496) [117055] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [117056] (1 PDB entry)

5. Cytokine receptor common gamma chain [141041] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [141042] (2 PDB entries)

6. Cytokine receptor gp130 cytokine-binding domains [49295] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [49296] (5 PDB entries)

7. Down syndrome cell adhesion molecule-like protein 1, DSCAML1 [141055] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [141056] (1 PDB entry)

8. Ephrin type-A receptor 1 [141063] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [141064] (1 PDB entry)

9. Ephrin type-A receptor 8 [141039] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [141040] (1 PDB entry)
     structure of the C-terminal SAM domain is known (scop_sp 101243)

10. Ephrin type-B receptor 1 [141035] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141036] (1 PDB entry)

11. Erythropoietin (EPO) receptor [49282] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49283] (5 PDB entries)

12. Extracellular region of human tissue factor [49267] (2 species)
    tandem of fibronectin type III domains

    1. Species Human (Homo sapiens) [TaxId:9606] [49268] (10 PDB entries)

    2. Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [49269] (18 PDB entries)

13. Fibronectin type 3 and ankyrin repeat domains 1 protein, FANK1 [117053] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [117054] (1 PDB entry)

14. Fibronectin type III domain from chitinase A1. [81975] (1 species)

    • Species Bacillus circulans [TaxId:1397] [81976] (1 PDB entry)

15. Fibronectin type-III domain containing protein 3a, FNDC3A (KIAA0970) [117057] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [117058] (6 PDB entries)

16. Fibronectin, different Fn3 modules [49270] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [49271] (9 PDB entries)

    2. Species Mouse (Mus musculus) [TaxId:10090] [49272] (2 PDB entries)

17. Granulocyte colony-stimulating factor (GC-SF) receptor [49291] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [141034] (1 PDB entry)

    2. Species Mouse (Mus musculus) [TaxId:10090] [49292] (4 PDB entries)

18. Growth hormone receptor [49280] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49281] (7 PDB entries)
      tandem of fibronectin type III domains

19. Hedgehog receptor iHog [141061] (1 species)
    Cg9211-PA

    • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [141062] (3 PDB entries)

20. Host cell factor 2, HCF-2 [117051] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [117052] (1 PDB entry)

21. Integrin beta-4 subunit [49278] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49279] (1 PDB entry)

22. Interferon-alpha/beta receptor beta chain [89199] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [89200] (3 PDB entries)

23. Interferon-gamma receptor alpha chain [49293] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49294] (3 PDB entries)

24. Interleukin-10 receptor 1, IL-10R1 [63670] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [63671] (5 PDB entries)

25. Interleukin-2 receptor beta chain [141047] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141048] (2 PDB entries)

26. Interleukin-4 receptor alpha chain [49287] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49288] (1 PDB entry)

27. Interleukin-6 receptor alpha chain, domains 2 and 3 [81977] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [81978] (3 PDB entries)

28. KIAA0343 protein [101531] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101532] (2 PDB entries)

29. KIAA1355 [110058] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [110059] (1 PDB entry)

30. KIAA1568 protein [101529] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [101530] (2 PDB entries)

31. Myosin binding protein C, fast-type [141057] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [141058] (1 PDB entry)

32. Neogenin [141053] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141054] (6 PDB entries)

33. Neural cell adhesion molecule 1, NCAM [89197] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [141033] (1 PDB entry)

    2. Species Rat (Rattus norvegicus) [TaxId:10116] [89198] (1 PDB entry)

34. Neuroglian, two amino proximal Fn3 repeats [49276] (1 species)
    tandem of fibronectin type III domains

    • Species Drosophila melanogaster [TaxId:7227] [49277] (1 PDB entry)

35. Prolactin receptor [49284] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [49285] (1 PDB entry)

    2. Species Rat (Rattus norvegicus) [TaxId:10116] [49286] (1 PDB entry)

36. Receptor-type tyrosine-protein phosphatase delta, PTPRD [141049] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141050] (1 PDB entry)

37. Receptor-type tyrosine-protein phosphatase F, PTPRF [141059] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141060] (1 PDB entry)

38. Rim binding protein 2 [141043] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141044] (1 PDB entry)

39. Sidekick 2 [141051] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141052] (4 PDB entries)

40. Tenascin [49273] (3 species)

    1. Species Chicken (Gallus gallus) [TaxId:9031] [49274] (1 PDB entry)

    2. Species Human (Homo sapiens) [TaxId:9606] [49275] (1 PDB entry)

    3. Species Rat (Rattus norvegicus) [TaxId:10116] [110057] (1 PDB entry)

41. Tenascin-X [141045] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [141046] (3 PDB entries)

42. The p40 domain of interleukin-12 (IL-12 beta chain), domains 2 and 3 [63672] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [63673] (2 PDB entries)

43. Type I titin module [49297] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49298] (1 PDB entry)

More info for Family b.1.2.1: Fibronectin type III

Timeline for Family b.1.2.1: Fibronectin type III:

• Family b.1.2.1: Fibronectin type III first appeared (with stable ids) in SCOP 1.55
  
• Family b.1.2.1: Fibronectin type III appears in SCOP 1.71
  
• Family b.1.2.1: Fibronectin type III appears in SCOP 1.75
  
• Family b.1.2.1: Fibronectin type III appears in the current release, SCOPe 2.08