SCOP 1.65: Family b.1.1.4: I set domains

Lineage for Family b.1.1.4: I set domains

1. Root: SCOP 1.65

2. Class b: All beta proteins [48724] (126 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (20 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (4 families)

5. Family b.1.1.4: I set domains [49159] (29 proteins)

Proteins:

1. Axonin-1 [49184] (1 species)
   tandem repeat of 4 L1 domains

   • Species Chicken (Gallus gallus) [TaxId:9031] [49185] (1 PDB entry)

2. Biliary glycoprotein C (CD66a, CEACAM1A[1,4]), C-terminal domain [81956] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [81957] (1 PDB entry)

3. Cardiac myosin binding protein C, central domain [89185] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [89186] (1 PDB entry)

4. CD3 epsilon chain ectodomain fragment [69162] (1 species)
   possibly an intermediate structure between the I set and FnIII domains

   • Species Mouse (Mus musculus) [TaxId:10090] [69163] (1 PDB entry)

5. CD3 gamma chain ectodomain fragment [69160] (1 species)
   possibly an intermediate structure between the I set and FnIII domains

   • Species Mouse (Mus musculus) [TaxId:10090] [69161] (1 PDB entry)

6. Fc gamma receptor ectodomain (CD32) [49196] (3 species)
   possibly an intermediate structure between the I set and FnIII domains

   1. Species Human (Homo sapiens), IIa [TaxId:9606] [49197] (2 PDB entries)

   2. Species Human (Homo sapiens), IIb [TaxId:9606] [49198] (1 PDB entry)

   3. Species Human (Homo sapiens), III [TaxId:9606] [49199] (5 PDB entries)

7. Fibroblast growth factor receptor, FGFR [49179] (3 species)

   1. Species Human (Homo sapiens), FGFR1 [TaxId:9606] [49180] (3 PDB entries)

   2. Species Human (Homo sapiens), FGFR2a [TaxId:9606] [49181] (5 PDB entries)

   3. Species Human (Homo sapiens), FGFR2b [TaxId:9606] [81955] (1 PDB entry)

8. Hemolin [49182] (1 species)
   Duplication: tandem repeat of 4 domains, known as L1 domains

   • Species Moth (Hyalophora cecropia) [TaxId:7123] [49183] (1 PDB entry)

9. Ig alpha Fc receptor, FCARI (CD89) [89188] (1 species)
   possibly an intermediate structure between the I set and FnIII domains

   • Species Human (Homo sapiens) [TaxId:9606] [89189] (3 PDB entries)

10. IgE high affinity receptor alpha subunit [49200] (1 species)
    possibly an intermediate structure between the I set and FnIII domains

    • Species Human (Homo sapiens) [TaxId:9606] [49201] (6 PDB entries)

11. Interleukin-6 receptor alpha chain, N-teminal domain [81958] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [81959] (1 PDB entry)

12. Junction adhesion molecule, JAM, C-terminal domain [49186] (2 species)

    1. Species Human (Homo sapiens) [TaxId:9606] [89187] (1 PDB entry)

    2. Species Mouse (Mus musculus) [TaxId:10090] [49187] (1 PDB entry)

13. Killer cell inhibitory receptor [49202] (4 species)
    possibly an intermediate structure between the I set and FnIII domains

    1. Species Human (Homo sapiens), 2dl2 [TaxId:9606] [49205] (2 PDB entries)

    2. Species Human (Homo sapiens), kir2dl3 [TaxId:9606] [49203] (2 PDB entries)

    3. Species Human (Homo sapiens), kir2ds3, CD158j [TaxId:9606] [89190] (1 PDB entry)

    4. Species Human (Homo sapiens), p58-cl42 kir [TaxId:9606] [49204] (2 PDB entries)

14. Ligand binding domain of lir-1 (ilt2) [49206] (1 species)
    possibly an intermediate structure between the I set and FnIII domains

    • Species Human (Homo sapiens) [TaxId:9606] [49207] (1 PDB entry)

15. Ligand binding domain of trkB receptor [49192] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49193] (2 PDB entries)

16. Mucosal addressin cell adhesion molecule-1 (MADCAM-1) [49168] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49169] (2 PDB entries)

17. N-terminal domain of intracellular adhesion molecule-1, ICAM-1 [49162] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49163] (4 PDB entries)

18. N-terminal domain of intracellular adhesion molecule-2, ICAM-2 [49164] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49165] (1 PDB entry)

19. N-terminal domain of vascular cell adhesion molecule-1 (VCAM-1) [49160] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49161] (3 PDB entries)

20. Neural cell adhesion molecule (NCAM) [49166] (2 species)

    1. Species Chicken (Gallus gallus) [TaxId:9031] [63664] (1 PDB entry)

    2. Species Rat (Rattus norvegicus) [TaxId:10116] [49167] (3 PDB entries)
       Rat and mouse sequences are identical for the two N-terminal modules

21. NGF binding domain of trkA receptor [49190] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49191] (3 PDB entries)

22. NT3 binding domain of trkC receptor [49194] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49195] (1 PDB entry)

23. Perlecan Ig3 domain [69158] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [69159] (1 PDB entry)

24. Second domain of the Flt-1 receptor [49188] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [49189] (4 PDB entries)

25. Telokin [49170] (1 species)

    • Species Turkey (Meleagris gallopavo) [TaxId:9103] [49171] (2 PDB entries)

26. The p40 domain of interleukin-12 (IL-12 beta chain), N-teminal domain [63665] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [63666] (2 PDB entries)

27. Titin [49172] (1 species)

    • Species Human (Homo sapiens), different modules [TaxId:9606] [49173] (5 PDB entries)

28. Twitchin [49174] (2 species)

    1. Species Human (Homo sapiens), Ig repeat 27 [TaxId:9606] [49176] (2 PDB entries)

    2. Species Nematode (Caenorhabditis elegans) [TaxId:6239] [49175] (3 PDB entries)
       different modules

29. Type-1 interleukin-1 receptor [49177] (1 species)
    duplication: tandem repeat of 3 domains

    • Species Human (Homo sapiens) [TaxId:9606] [49178] (3 PDB entries)

More info for Family b.1.1.4: I set domains

Timeline for Family b.1.1.4: I set domains:

• Family b.1.1.4: I set domains first appeared (with stable ids) in SCOP 1.55
  
• Family b.1.1.4: I set domains appears in SCOP 1.63
  
• Family b.1.1.4: I set domains appears in SCOP 1.67
  
• Family b.1.1.4: I set domains appears in the current release, SCOPe 2.08