Lineage for Family b.1.1.2: C1 set domains (antibody constant domain-like)

  1. Root: SCOPe 2.06
  2. 2021373Class b: All beta proteins [48724] (177 folds)
  3. 2021374Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 2021375Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 2025133Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

Proteins:

  1. 2025134beta2-microglobulin [88600] (6 species)
    1. 2025135Species Cow (Bos taurus) [TaxId:9913] [48946] (6 PDB entries)
    2. 2025146Species Felis catus [TaxId:9685] [342900] (2 PDB entries)
    3. 2025149Species Human (Homo sapiens) [TaxId:9606] [88602] (424 PDB entries)
      Uniprot P61769 21-119 ! Uniprot P01884
    4. 2025828Species Mouse (Mus musculus) [TaxId:10090] [88603] (182 PDB entries)
      Uniprot P01887
    5. 2026114Species Norway rat (Rattus norvegicus) [TaxId:10116] [88601] (6 PDB entries)
    6. 2026124Species Pig (Sus scrofa) [TaxId:9823] [189845] (2 PDB entries)
  2. 2026128CD1, alpha-3 domain [88615] (5 species)
    1. 2026129Species Cow (Bos taurus) [TaxId:9913] [226527] (2 PDB entries)
    2. 2026133Species Human (Homo sapiens), CD1a [TaxId:9606] [101513] (5 PDB entries)
    3. 2026143Species Human (Homo sapiens), CD1b [TaxId:9606] [88617] (10 PDB entries)
    4. 2026156Species Human (Homo sapiens), CD1d [TaxId:9606] [158876] (2 PDB entries)
      Uniprot P15813 202-295
    5. 2026160Species Mouse (Mus musculus) [TaxId:10090] [88616] (9 PDB entries)
  3. 2026173Class I MHC homolog, alpha-3 domain [88610] (4 species)
    gamma, delta T-cell ligand
    1. 2026174Species Human (Homo sapiens), Mic-a [TaxId:9606] [48968] (2 PDB entries)
    2. 2026177Species Human (Homo sapiens), Mic-b [TaxId:9606] [74826] (1 PDB entry)
    3. 2026179Species Mouse (Mus musculus), t10 [TaxId:10090] [101512] (1 PDB entry)
    4. 2026184Species Mouse (Mus musculus), t22 [TaxId:10090] [88611] (2 PDB entries)
  4. 2026191Class I MHC, alpha-3 domain [88604] (4 species)
    1. 2026192Species Human (Homo sapiens) [TaxId:9606] [88605] (199 PDB entries)
      Uniprot P30685 25-300 ! Uniprot P30443 25-298 # 1A01_HUMAN HLA class I histocompatibility antigen, A-1 alpha chain precursor ! Uniprot P30481 25-300 ! Uniprot P01892 25-298 ! Uniprot P13746 25-299 # 1A11_HUMAN HLA class I histocompatibility antigen, A-11 alpha chain precursor
    2. 2026491Species Mouse (Mus musculus) [TaxId:10090] [88606] (109 PDB entries)
      Uniprot P01901 22-299
    3. 2026679Species Norway rat (Rattus norvegicus), RT1-AA [TaxId:10116] [88607] (3 PDB entries)
    4. 2026684Species Rhesus monkey (Macaca mulatta) [TaxId:9544] [158875] (1 PDB entry)
  5. 2026687Class II MHC alpha chain, C-terminal domain [88618] (6 species)
    1. 2026688Species Human (Homo sapiens), HLA-DM [TaxId:9606] [88619] (1 PDB entry)
      probably orthologous to the mouse H2-DM
    2. 2026690Species Human (Homo sapiens), HLA-DQ group [TaxId:9606] [88623] (3 PDB entries)
      probably orthologous to the mouse I-A group
    3. 2026695Species Human (Homo sapiens), HLA-DR group [TaxId:9606] [88621] (37 PDB entries)
      Uniprot P01903 28-207
      probably orthologous to the mouse I-E group
    4. 2026751Species Mouse (Mus musculus), H2-DM [TaxId:10090] [88620] (1 PDB entry)
      probably orthologous to the human HLA-DM
    5. 2026753Species Mouse (Mus musculus), I-A group [TaxId:10090] [88624] (27 PDB entries)
      probably orthologous to the human HLA-DQ group
    6. 2026795Species Mouse (Mus musculus), I-E group [TaxId:10090] [88622] (9 PDB entries)
      probably orthologous to the human HLA-DR group
  6. 2026816Class II MHC beta chain, C-terminal domain [88625] (6 species)
    1. 2026817Species Human (Homo sapiens), HLA-DM [TaxId:9606] [88626] (1 PDB entry)
      probably orthologous to the mouse H2-DM
    2. 2026819Species Human (Homo sapiens), HLA-DQ group [TaxId:9606] [88630] (3 PDB entries)
      probably orthologous to the mouse I-A group
    3. 2026824Species Human (Homo sapiens), HLA-DR group [TaxId:9606] [88628] (41 PDB entries)
      Uniprot P04229 30-219
      probably orthologous to the mouse I-E group
    4. 2026887Species Mouse (Mus musculus), H2-DM [TaxId:10090] [88627] (1 PDB entry)
      probably orthologous to the human HLA-DM
    5. 2026889Species Mouse (Mus musculus), I-A group [TaxId:10090] [88631] (17 PDB entries)
      probably orthologous to the human HLA-DQ group
    6. 2026916Species Mouse (Mus musculus), I-E group [TaxId:10090] [88629] (9 PDB entries)
      probably orthologous to the human HLA-DR group
  7. 2026937Fc (IgG) receptor, alpha-3 domain [88612] (2 species)
    1. 2026938Species Human (Homo sapiens) [TaxId:9606] [88614] (1 PDB entry)
    2. 2026940Species Norway rat (Rattus norvegicus) [TaxId:10116] [88613] (3 PDB entries)
  8. 2026946Hemochromatosis protein Hfe, alpha-3 domain [88608] (1 species)
  9. 2026953Immunoglobulin heavy chain alpha constant domain 1, CH1-alpha [88580] (1 species)
  10. 2026958Immunoglobulin heavy chain alpha constant domain 2, CH2-alpha [89181] (1 species)
  11. 2026964Immunoglobulin heavy chain alpha constant domain 3, CH3-alpha [89183] (1 species)
  12. 2026970Immunoglobulin heavy chain epsilon constant domain 2, CH2-epsilon [88594] (1 species)
  13. 2026977Immunoglobulin heavy chain epsilon constant domain 3, CH3-epsilon [88596] (1 species)
  14. 2026986Immunoglobulin heavy chain epsilon constant domain 4, CH4-epsilon [88598] (1 species)
  15. 2026995Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (7 species)
    1. 2026996Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [88579] (1 PDB entry)
    2. 2026999Species Escherichia coli [TaxId:316407] [343348] (1 PDB entry)
    3. 2027002Species Human (Homo sapiens) [TaxId:9606] [88575] (179 PDB entries)
      including humanized antibodies (chimeric proteins with human constant domains)
      Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody
    4. 2027314Species Mouse (Mus musculus) [TaxId:10090] [88576] (427 PDB entries)
      Uniprot P01864 # GCAB_MOUSE Ig gamma-2A chain C region secreted form (B allele) ! Uniprot P01863 #GCAA_MOUSE Ig gamma-2A chain C region, A allele; 86% sequence identity ! SQ NA # natural chimera; best hits are: Uniprot P01751 (Ig heavy chain V region B1-8/186-2) and Uniprot P01864 (Ig gamma-2A chain C region secreted form) ! Uniprot P01868 # GC1_MOUSE Ig gamma-1 chain C region secreted form ! Uniprot P01864 # GCAB_MOUSE (P01864) Ig gamma-2A chain C region ! Uniprot P01837 # KAC_MOUSE (P01837) Ig kappa chain C region ! Uniprot P01863 # GCAA_MOUSE Ig gamma-2A chain C region, A allele ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01868 # ! GC1_MOUSE Ig gamma-1 chain C region secreted form
    5. 2027869Species Mouse (Mus musculus), gamma3 [TaxId:10090] [88577] (8 PDB entries)
      Uniprot P22436 # GC3_MOUSE (P22436) Ig gamma-3 chain C region
    6. 2027883Species Norway rat (Rattus norvegicus) [TaxId:10116] [88578] (5 PDB entries)
    7. 2027896Species Synthetic construct [TaxId:32630] [158874] (1 PDB entry)
  16. 2027898Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma [88584] (4 species)
    1. 2027899Species Human (Homo sapiens) [TaxId:9606] [88585] (57 PDB entries)
      Uniprot P01857 #118-327 ! Uniprot P01857 118-327 # GC1_HUMAN Ig gamma-1 chain C region
    2. 2028013Species Mouse (Mus musculus) [TaxId:10090] [88586] (1 PDB entry)
    3. 2028016Species Mouse (Mus musculus), gamma2 [TaxId:10090] [88587] (1 PDB entry)
    4. 2028019Species Norway rat (Rattus norvegicus) [TaxId:10116] [88588] (3 PDB entries)
  17. 2028025Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma [88589] (5 species)
    1. 2028026Species Guinea pig (Cavia porcellus) [TaxId:10141] [49123] (1 PDB entry)
    2. 2028028Species Human (Homo sapiens) [TaxId:9606] [88590] (67 PDB entries)
      Uniprot P01857 #118-327 ! Uniprot P01857 118-327 # GC1_HUMAN Ig gamma-1 chain C region
    3. 2028162Species Mouse (Mus musculus) [TaxId:10090] [88591] (2 PDB entries)
    4. 2028167Species Mouse (Mus musculus), gamma2 [TaxId:10090] [88592] (1 PDB entry)
    5. 2028170Species Norway rat (Rattus norvegicus) [TaxId:10116] [88593] (3 PDB entries)
  18. 2028176Immunoglobulin heavy chain mu constant domain 1, CH1-mu [88582] (1 species)
  19. 2028190Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (4 species)
    1. 2028191Species Human (Homo sapiens) [TaxId:9606] [88569] (144 PDB entries)
      including humanized antibodies (chimeric proteins with human constant domains)
      SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody
    2. 2028422Species Mouse (Mus musculus) [TaxId:10090] [88567] (358 PDB entries)
      Uniprot P01837# KAC_MOUSE Ig kappa chain C region; 99% sequence identity ! SQ NA # natural chimera; best hits are: Uniprot P01637 (Ig kappa chain V-V region T1) and Uniprot P01837 (Ig kappa chain C region) ! Uniprot P01837 # KAC_MOUSE Ig kappa chain C region ! Uniprot P01837 # KAC_MOUSE (P01837) Ig kappa chain C region ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01837 # ! KAC_MOUSE Ig kappa chain C region
    3. 2028887Species Norway rat (Rattus norvegicus) [TaxId:10116] [88568] (5 PDB entries)
    4. 2028900Species Synthetic construct [TaxId:32630] [158871] (1 PDB entry)
  20. 2028905Immunoglobulin light chain lambda constant domain, CL-lambda [88570] (3 species)
    1. 2028906Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [88573] (1 PDB entry)
    2. 2028909Species Human (Homo sapiens) [TaxId:9606] [88572] (46 PDB entries)
    3. 2028990Species Mouse (Mus musculus) [TaxId:10090] [88571] (21 PDB entries)
      Uniprot Q8N355 20-230 # 94% sequence identity; natural chimera: antibody light chain (Fab HYB3)
  21. 2029018Immunomodulatory protein m144, alpha-3 domain [110048] (1 species)
  22. 2029022T-cell antigen receptor [49125] (7 species)
    1. 2029023Species Human (Homo sapiens), alpha-chain [TaxId:9606] [49127] (24 PDB entries)
    2. 2029060Species Human (Homo sapiens), beta-chain [TaxId:9606] [49129] (29 PDB entries)
    3. 2029103Species Human (Homo sapiens), delta-chain [TaxId:9606] [63662] (2 PDB entries)
    4. 2029110Species Human (Homo sapiens), gamma-chain [TaxId:9606] [63661] (2 PDB entries)
    5. 2029117Species Mouse (Mus musculus) [TaxId:10090] [226194] (2 PDB entries)
    6. 2029120Species Mouse (Mus musculus), alpha-chain [TaxId:10090] [49126] (11 PDB entries)
    7. 2029141Species Mouse (Mus musculus), beta-chain [TaxId:10090] [49128] (15 PDB entries)
  23. 2029170Zinc-alpha-2-glycoprotein, ZAG, alpha-3 domain [48965] (1 species)
    fat depleting factor related to class I MHC
  24. 2029182automated matches [190374] (16 species)
    not a true protein
    1. 2029183Species Chimpanzee (Pan troglodytes) [TaxId:9598] [226268] (1 PDB entry)
    2. 2029186Species Cow (Bos taurus) [TaxId:9913] [225911] (1 PDB entry)
    3. 2029191Species Dengue virus [TaxId:12637] [335510] (1 PDB entry)
    4. 2029194Species Escherichia coli [TaxId:316407] [343296] (1 PDB entry)
    5. 2029197Species Escherichia coli [TaxId:562] [224854] (1 PDB entry)
    6. 2029202Species Felis catus [TaxId:9685] [342904] (2 PDB entries)
    7. 2029205Species Homo sapiens/mus [TaxId:1383439] [326991] (2 PDB entries)
    8. 2029210Species Human (Homo sapiens) [TaxId:9606] [187221] (698 PDB entries)
    9. 2030575Species Lama glama [TaxId:9844] [317148] (1 PDB entry)
    10. 2030577Species Llama glama [TaxId:9844] [271450] (2 PDB entries)
    11. 2030580Species Mouse (Mus musculus) [TaxId:10090] [224855] (498 PDB entries)
    12. 2031398Species Murinae, homo sapiens [TaxId:39107] [228176] (2 PDB entries)
    13. 2031403Species Norway rat (Rattus norvegicus) [TaxId:10116] [262079] (4 PDB entries)
    14. 2031416Species Other sequences [TaxId:28384] [313544] (1 PDB entry)
    15. 2031419Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [226687] (4 PDB entries)
    16. 2031425Species Rhesus monkey (Macaca mulatta) [TaxId:9544] [226134] (12 PDB entries)

More info for Family b.1.1.2: C1 set domains (antibody constant domain-like)

Timeline for Family b.1.1.2: C1 set domains (antibody constant domain-like):