Lineage for Family b.1.1.2: C1 set domains (antibody constant domain-like)

  1. Root: SCOPe 2.03
  2. 1287432Class b: All beta proteins [48724] (174 folds)
  3. 1287433Fold b.1: Immunoglobulin-like beta-sandwich [48725] (28 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 1287434Superfamily b.1.1: Immunoglobulin [48726] (5 families) (S)
  5. 1290587Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

Proteins:

  1. 1290588beta2-microglobulin [88600] (5 species)
    1. 1290589Species Cow (Bos taurus) [TaxId:9913] [48946] (6 PDB entries)
    2. 1290600Species Human (Homo sapiens) [TaxId:9606] [88602] (342 PDB entries)
      Uniprot P61769 21-119 ! Uniprot P01884
    3. 1291129Species Mouse (Mus musculus) [TaxId:10090] [88603] (155 PDB entries)
      Uniprot P01887
    4. 1291372Species Norway rat (Rattus norvegicus) [TaxId:10116] [88601] (6 PDB entries)
    5. 1291382Species Pig (Sus scrofa) [TaxId:9823] [189845] (2 PDB entries)
  2. 1291386CD1, alpha-3 domain [88615] (5 species)
    1. 1291387Species Cow (Bos taurus) [TaxId:9913] [226527] (2 PDB entries)
    2. 1291391Species Human (Homo sapiens), CD1a [TaxId:9606] [101513] (7 PDB entries)
    3. 1291404Species Human (Homo sapiens), CD1b [TaxId:9606] [88617] (4 PDB entries)
    4. 1291410Species Human (Homo sapiens), CD1d [TaxId:9606] [158876] (2 PDB entries)
      Uniprot P15813 202-295
    5. 1291415Species Mouse (Mus musculus) [TaxId:10090] [88616] (11 PDB entries)
  3. 1291430Class I MHC homolog, alpha-3 domain [88610] (4 species)
    gamma, delta T-cell ligand
    1. 1291431Species Human (Homo sapiens), Mic-a [TaxId:9606] [48968] (2 PDB entries)
    2. 1291434Species Human (Homo sapiens), Mic-b [TaxId:9606] [74826] (1 PDB entry)
    3. 1291436Species Mouse (Mus musculus), t10 [TaxId:10090] [101512] (1 PDB entry)
    4. 1291441Species Mouse (Mus musculus), t22 [TaxId:10090] [88611] (2 PDB entries)
  4. 1291448Class I MHC, alpha-3 domain [88604] (4 species)
    1. 1291449Species Human (Homo sapiens) [TaxId:9606] [88605] (186 PDB entries)
      Uniprot P30685 25-300 ! Uniprot P30443 25-298 # 1A01_HUMAN HLA class I histocompatibility antigen, A-1 alpha chain precursor ! Uniprot P30481 25-300 ! Uniprot P01892 25-298 ! Uniprot P13746 25-299 # 1A11_HUMAN HLA class I histocompatibility antigen, A-11 alpha chain precursor
    2. 1291720Species Mouse (Mus musculus) [TaxId:10090] [88606] (101 PDB entries)
      Uniprot P01901 22-299
    3. 1291891Species Norway rat (Rattus norvegicus), RT1-AA [TaxId:10116] [88607] (3 PDB entries)
    4. 1291896Species Rhesus monkey (Macaca mulatta) [TaxId:9544] [158875] (1 PDB entry)
  5. 1291899Class II MHC alpha chain, C-terminal domain [88618] (6 species)
    1. 1291900Species Human (Homo sapiens), HLA-DM [TaxId:9606] [88619] (1 PDB entry)
      probably orthologous to the mouse H2-DM
    2. 1291902Species Human (Homo sapiens), HLA-DQ group [TaxId:9606] [88623] (3 PDB entries)
      probably orthologous to the mouse I-A group
    3. 1291907Species Human (Homo sapiens), HLA-DR group [TaxId:9606] [88621] (37 PDB entries)
      Uniprot P01903 28-207
      probably orthologous to the mouse I-E group
    4. 1291963Species Mouse (Mus musculus), H2-DM [TaxId:10090] [88620] (1 PDB entry)
      probably orthologous to the human HLA-DM
    5. 1291965Species Mouse (Mus musculus), I-A group [TaxId:10090] [88624] (24 PDB entries)
      probably orthologous to the human HLA-DQ group
    6. 1292005Species Mouse (Mus musculus), I-E group [TaxId:10090] [88622] (9 PDB entries)
      probably orthologous to the human HLA-DR group
  6. 1292026Class II MHC beta chain, C-terminal domain [88625] (6 species)
    1. 1292027Species Human (Homo sapiens), HLA-DM [TaxId:9606] [88626] (1 PDB entry)
      probably orthologous to the mouse H2-DM
    2. 1292029Species Human (Homo sapiens), HLA-DQ group [TaxId:9606] [88630] (3 PDB entries)
      probably orthologous to the mouse I-A group
    3. 1292034Species Human (Homo sapiens), HLA-DR group [TaxId:9606] [88628] (41 PDB entries)
      Uniprot P04229 30-219
      probably orthologous to the mouse I-E group
    4. 1292097Species Mouse (Mus musculus), H2-DM [TaxId:10090] [88627] (1 PDB entry)
      probably orthologous to the human HLA-DM
    5. 1292099Species Mouse (Mus musculus), I-A group [TaxId:10090] [88631] (16 PDB entries)
      probably orthologous to the human HLA-DQ group
    6. 1292125Species Mouse (Mus musculus), I-E group [TaxId:10090] [88629] (9 PDB entries)
      probably orthologous to the human HLA-DR group
  7. 1292146Fc (IgG) receptor, alpha-3 domain [88612] (2 species)
    1. 1292147Species Human (Homo sapiens) [TaxId:9606] [88614] (1 PDB entry)
    2. 1292149Species Norway rat (Rattus norvegicus) [TaxId:10116] [88613] (3 PDB entries)
  8. 1292155Hemochromatosis protein Hfe, alpha-3 domain [88608] (1 species)
  9. 1292162Immunoglobulin heavy chain alpha constant domain 1, CH1-alpha [88580] (1 species)
  10. 1292167Immunoglobulin heavy chain alpha constant domain 2, CH2-alpha [89181] (1 species)
  11. 1292173Immunoglobulin heavy chain alpha constant domain 3, CH3-alpha [89183] (1 species)
  12. 1292179Immunoglobulin heavy chain epsilon constant domain 2, CH2-epsilon [88594] (1 species)
  13. 1292184Immunoglobulin heavy chain epsilon constant domain 3, CH3-epsilon [88596] (1 species)
  14. 1292191Immunoglobulin heavy chain epsilon constant domain 4, CH4-epsilon [88598] (1 species)
  15. 1292198Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (6 species)
    1. 1292199Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [88579] (1 PDB entry)
    2. 1292202Species Human (Homo sapiens) [TaxId:9606] [88575] (177 PDB entries)
      including humanized antibodies (chimeric proteins with human constant domains)
      Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody
    3. 1292510Species Mouse (Mus musculus) [TaxId:10090] [88576] (414 PDB entries)
      Uniprot P01864 # GCAB_MOUSE Ig gamma-2A chain C region secreted form (B allele) ! Uniprot P01863 #GCAA_MOUSE Ig gamma-2A chain C region, A allele; 86% sequence identity ! SQ NA # natural chimera; best hits are: Uniprot P01751 (Ig heavy chain V region B1-8/186-2) and Uniprot P01864 (Ig gamma-2A chain C region secreted form) ! Uniprot P01868 # GC1_MOUSE Ig gamma-1 chain C region secreted form ! Uniprot P01864 # GCAB_MOUSE (P01864) Ig gamma-2A chain C region ! Uniprot P01837 # KAC_MOUSE (P01837) Ig kappa chain C region ! Uniprot P01863 # GCAA_MOUSE Ig gamma-2A chain C region, A allele ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01868 # ! GC1_MOUSE Ig gamma-1 chain C region secreted form
    4. 1293052Species Mouse (Mus musculus), gamma3 [TaxId:10090] [88577] (8 PDB entries)
      Uniprot P22436 # GC3_MOUSE (P22436) Ig gamma-3 chain C region
    5. 1293066Species Norway rat (Rattus norvegicus) [TaxId:10116] [88578] (5 PDB entries)
    6. 1293079Species Synthetic construct [TaxId:32630] [158874] (3 PDB entries)
  16. 1293085Immunoglobulin heavy chain gamma constant domain 2, CH2-gamma [88584] (4 species)
    1. 1293086Species Human (Homo sapiens) [TaxId:9606] [88585] (33 PDB entries)
      Uniprot P01857 #118-327 ! Uniprot P01857 118-327 # GC1_HUMAN Ig gamma-1 chain C region
    2. 1293145Species Mouse (Mus musculus) [TaxId:10090] [88586] (1 PDB entry)
    3. 1293148Species Mouse (Mus musculus), gamma2 [TaxId:10090] [88587] (1 PDB entry)
    4. 1293151Species Norway rat (Rattus norvegicus) [TaxId:10116] [88588] (3 PDB entries)
  17. 1293157Immunoglobulin heavy chain gamma constant domain 3, CH3-gamma [88589] (5 species)
    1. 1293158Species Guinea pig (Cavia porcellus) [TaxId:10141] [49123] (1 PDB entry)
    2. 1293160Species Human (Homo sapiens) [TaxId:9606] [88590] (33 PDB entries)
      Uniprot P01857 #118-327 ! Uniprot P01857 118-327 # GC1_HUMAN Ig gamma-1 chain C region
    3. 1293222Species Mouse (Mus musculus) [TaxId:10090] [88591] (2 PDB entries)
    4. 1293227Species Mouse (Mus musculus), gamma2 [TaxId:10090] [88592] (1 PDB entry)
    5. 1293230Species Norway rat (Rattus norvegicus) [TaxId:10116] [88593] (3 PDB entries)
  18. 1293236Immunoglobulin heavy chain mu constant domain 1, CH1-mu [88582] (1 species)
  19. 1293251Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (4 species)
    1. 1293252Species Human (Homo sapiens) [TaxId:9606] [88569] (147 PDB entries)
      including humanized antibodies (chimeric proteins with human constant domains)
      SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody
    2. 1293486Species Mouse (Mus musculus) [TaxId:10090] [88567] (364 PDB entries)
      Uniprot P01837# KAC_MOUSE Ig kappa chain C region; 99% sequence identity ! SQ NA # natural chimera; best hits are: Uniprot P01637 (Ig kappa chain V-V region T1) and Uniprot P01837 (Ig kappa chain C region) ! Uniprot P01837 # KAC_MOUSE Ig kappa chain C region ! Uniprot P01837 # KAC_MOUSE (P01837) Ig kappa chain C region ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01837 # ! KAC_MOUSE Ig kappa chain C region
    3. 1293967Species Norway rat (Rattus norvegicus) [TaxId:10116] [88568] (6 PDB entries)
    4. 1293982Species Synthetic construct [TaxId:32630] [158871] (2 PDB entries)
  20. 1293989Immunoglobulin light chain lambda constant domain, CL-lambda [88570] (3 species)
    1. 1293990Species Chinese hamster (Cricetulus griseus) [TaxId:10029] [88573] (1 PDB entry)
    2. 1293993Species Human (Homo sapiens) [TaxId:9606] [88572] (46 PDB entries)
    3. 1294075Species Mouse (Mus musculus) [TaxId:10090] [88571] (21 PDB entries)
      Uniprot Q8N355 20-230 # 94% sequence identity; natural chimera: antibody light chain (Fab HYB3)
  21. 1294103Immunomodulatory protein m144, alpha-3 domain [110048] (1 species)
  22. 1294107T-cell antigen receptor [49125] (7 species)
    1. 1294108Species Human (Homo sapiens), alpha-chain [TaxId:9606] [49127] (20 PDB entries)
    2. 1294138Species Human (Homo sapiens), beta-chain [TaxId:9606] [49129] (31 PDB entries)
    3. 1294184Species Human (Homo sapiens), delta-chain [TaxId:9606] [63662] (2 PDB entries)
    4. 1294191Species Human (Homo sapiens), gamma-chain [TaxId:9606] [63661] (2 PDB entries)
    5. 1294198Species Mouse (Mus musculus) [TaxId:10090] [226194] (2 PDB entries)
    6. 1294201Species Mouse (Mus musculus), alpha-chain [TaxId:10090] [49126] (11 PDB entries)
    7. 1294222Species Mouse (Mus musculus), beta-chain [TaxId:10090] [49128] (15 PDB entries)
  23. 1294251Zinc-alpha-2-glycoprotein, ZAG, alpha-3 domain [48965] (1 species)
    fat depleting factor related to class I MHC
  24. 1294263automated matches [190374] (12 species)
    not a true protein
    1. 1294264Species Chimpanzee (Pan troglodytes) [TaxId:9598] [226268] (1 PDB entry)
    2. 1294267Species Cow (Bos taurus) [TaxId:9913] [225911] (1 PDB entry)
    3. 1294272Species Escherichia coli [TaxId:562] [224854] (11 PDB entries)
    4. 1294292Species Homo sapiens [TaxId:9606] [225511] (1 PDB entry)
    5. 1294295Species Human (Homo sapiens) [TaxId:9606] [187221] (293 PDB entries)
    6. 1294862Species Mouse (Mus musculus) [TaxId:10090] [224855] (237 PDB entries)
    7. 1295255Species Murinae,homo sapiens [TaxId:39107] [228176] (2 PDB entries)
    8. 1295260Species Mus musculus [TaxId:10090] [226774] (1 PDB entry)
    9. 1295262Species Mus musculus [TaxId:10090] [238130] (4 PDB entries)
    10. 1295270Species Mus musculus, [TaxId:10090] [237991] (4 PDB entries)
    11. 1295275Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [226687] (1 PDB entry)
    12. 1295277Species Rhesus monkey (Macaca mulatta) [TaxId:9544] [226134] (3 PDB entries)

More info for Family b.1.1.2: C1 set domains (antibody constant domain-like)

Timeline for Family b.1.1.2: C1 set domains (antibody constant domain-like):