Lineage for Family b.1.1.1: V set domains (antibody variable domain-like)

  1. Root: SCOP 1.71
  2. 546417Class b: All beta proteins [48724] (149 folds)
  3. 546418Fold b.1: Immunoglobulin-like beta-sandwich [48725] (25 superfamilies)
    sandwich; 7 strands in 2 sheets; greek-key
    some members of the fold have additional strands
  4. 546419Superfamily b.1.1: Immunoglobulin [48726] (4 families) (S)
  5. 546420Family b.1.1.1: V set domains (antibody variable domain-like) [48727] (28 proteins)

Proteins:

  1. 546421Biliary glycoprotein C (CD66a, CEACAM1A[1,4]), N-terminal domain [81942] (1 species)
  2. 546424Camelid IG heavy chain variable domain, VHh [88563] (2 species)
    1. 546425Species Camel (Camelus dromedarius) [TaxId:9838] [88564] (13 PDB entries)
    2. 546453Species Llama (Lama glama) [TaxId:9844] [88565] (7 PDB entries)
  3. 546462CD2, first domain [48740] (2 species)
    1. 546463Species Human (Homo sapiens) [TaxId:9606] [48741] (4 PDB entries)
    2. 546469Species Rat (Rattus norvegicus) [TaxId:10116] [48742] (5 PDB entries)
  4. 546482CD2-binding domain of CD58, N-terminal domain [48743] (1 species)
  5. 546488CD4 V-set domains [48737] (2 species)
    1. 546489Species Human (Homo sapiens) [TaxId:9606] [48738] (15 PDB entries)
    2. 546514Species Rat (Rattus rattus) [TaxId:10117] [48739] (1 PDB entry)
  6. 546516CD8 [48734] (2 species)
    1. 546517Species Human (Homo sapiens) [TaxId:9606] [48735] (2 PDB entries)
    2. 546521Species Mouse (Mus musculus) [TaxId:10090] [48736] (2 PDB entries)
  7. 546528CD80, N-terminal domain [48745] (1 species)
    a soluble form of b7-1
  8. 546533CD86 (b7-2), N-terminal domain [63635] (1 species)
  9. 546539Coxsackie virus and adenovirus receptor (Car), domain 1 [48730] (1 species)
  10. 546549HSV glycoprotein D [63637] (1 species)
  11. 546556Immunoglobulin heavy chain variable domain, VH [88543] (20 species)
    VH domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VH domains with artificial or grafted exogenous CDRs are listed as engineered species
    1. 546557Species Engineered (including hybrid species) [88562] (52 PDB entries)
    2. 546630Species Hamster (Cricetulus griseus) [TaxId:10029] [88561] (1 PDB entry)
    3. 546633Species Human (Homo sapiens), cluster 1 [TaxId:9606] [88544] (15 PDB entries)
    4. 546661Species Human (Homo sapiens), cluster 2.1 [TaxId:9606] [88545] (3 PDB entries)
    5. 546667Species Human (Homo sapiens), cluster 2.2 [TaxId:9606] [88546] (1 PDB entry)
    6. 546669Species Human (Homo sapiens), cluster 3 [TaxId:9606] [88547] (12 PDB entries)
    7. 546687Species Human (Homo sapiens), cluster 4 [TaxId:9606] [101505] (1 PDB entry)
    8. 546690Species Mouse (Mus musculus), cluster 1 [TaxId:10090] [88548] (42 PDB entries)
    9. 546744Species Mouse (Mus musculus), cluster 2.1 [TaxId:10090] [88549] (16 PDB entries)
    10. 546768Species Mouse (Mus musculus), cluster 2.2 [TaxId:10090] [88550] (49 PDB entries)
    11. 546842Species Mouse (Mus musculus), cluster 3.1 [TaxId:10090] [88551] (33 PDB entries)
    12. 546882Species Mouse (Mus musculus), cluster 3.2 [TaxId:10090] [88552] (148 PDB entries)
    13. 547076Species Mouse (Mus musculus), cluster 3.3 [TaxId:10090] [88553] (1 PDB entry)
    14. 547079Species Mouse (Mus musculus), cluster 4 [TaxId:10090] [88554] (32 PDB entries)
    15. 547125Species Mouse (Mus musculus), cluster 5 [TaxId:10090] [88555] (36 PDB entries)
    16. 547173Species Mouse (Mus musculus), cluster 6 [TaxId:10090] [88556] (12 PDB entries)
    17. 547188Species Mouse (Mus musculus), cluster 7.1 [TaxId:10090] [88557] (34 PDB entries)
    18. 547229Species Mouse (Mus musculus), cluster 7.2 [TaxId:10090] [88558] (20 PDB entries)
    19. 547252Species Mouse (Mus musculus), cluster 7.3 [TaxId:10090] [88559] (2 PDB entries)
    20. 547255Species Rat (Rattus norvegicus) [TaxId:10116] [88560] (14 PDB entries)
  12. 547289Immunoglobulin light chain kappa variable domain, VL-kappa [88519] (14 species)
    VL-kappa domains of human and mouse antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the species genomes; VL-kappa domains with artificial or grafted exogenous CDRs are listed as engineered species
    1. 547290Species Engineered (including hybrid species) [88533] (52 PDB entries)
    2. 547362Species Human (Homo sapiens), cluster 1 [TaxId:9606] [88520] (18 PDB entries)
    3. 547405Species Human (Homo sapiens), cluster 2 [TaxId:9606] [88521] (10 PDB entries)
    4. 547421Species Human (Homo sapiens), cluster 3.1 [TaxId:9606] [88522] (5 PDB entries)
    5. 547431Species Human (Homo sapiens), cluster 3.2 [TaxId:9606] [88523] (7 PDB entries)
    6. 547441Species Mouse (Mus musculus), cluster 1.1 [TaxId:10090] [88524] (126 PDB entries)
    7. 547602Species Mouse (Mus musculus), cluster 1.2 [TaxId:10090] [88525] (35 PDB entries)
    8. 547654Species Mouse (Mus musculus), cluster 2 [TaxId:10090] [88526] (24 PDB entries)
    9. 547687Species Mouse (Mus musculus), cluster 3.1 [TaxId:10090] [88527] (12 PDB entries)
    10. 547704Species Mouse (Mus musculus), cluster 3.2 [TaxId:10090] [88528] (19 PDB entries)
    11. 547731Species Mouse (Mus musculus), cluster 3.3 [TaxId:10090] [88529] (2 PDB entries)
    12. 547735Species Mouse (Mus musculus), cluster 3.4 [TaxId:10090] [88530] (3 PDB entries)
    13. 547739Species Mouse (Mus musculus), cluster 4 [TaxId:10090] [88531] (170 PDB entries)
    14. 547956Species Rat (Rattus norvegicus) [TaxId:10116] [88532] (7 PDB entries)
  13. 547970Immunoglobulin light chain lambda variable domain, VL-lambda [88534] (9 species)
    VL-lambda domains of human antibodies are clustered by the sequence similarity within the germline encoded segment and then by the size of the complementarity determining regions CDR1 and CDR2, so the clusters may correspond to putative germline families in the human genome; mouse VL-lambda domains belong to a single germline family
    1. 547971Species Hamster (Cricetulus griseus) [TaxId:10029] [88542] (1 PDB entry)
    2. 547974Species Human (Homo sapiens), cluster 1 [TaxId:9606] [88535] (4 PDB entries)
    3. 547983Species Human (Homo sapiens), cluster 2 [TaxId:9606] [88536] (9 PDB entries)
    4. 547997Species Human (Homo sapiens), cluster 3.1 [TaxId:9606] [88537] (1 PDB entry)
    5. 547999Species Human (Homo sapiens), cluster 3.2 [TaxId:9606] [88538] (1 PDB entry)
    6. 548001Species Human (Homo sapiens), cluster 4 [TaxId:9606] [88539] (23 PDB entries)
    7. 548047Species Human (Homo sapiens), cluster 5 [TaxId:9606] [88540] (4 PDB entries)
    8. 548055Species Mouse (Mus musculus) [TaxId:10090] [88541] (33 PDB entries)
    9. 548100Species Rat (Rattus norvegicus) [TaxId:10116] [101504] (7 PDB entries)
  14. 548121Immunoreceptor CTLA-4 (CD152), N-terminal fragment [48939] (2 species)
    1. 548122Species Human (Homo sapiens) [TaxId:9606] [48940] (3 PDB entries)
    2. 548128Species Mouse (Mus musculus) [TaxId:10090] [48941] (1 PDB entry)
  15. 548133Junction adhesion molecule, JAM, N-terminal domain [48747] (2 species)
    1. 548134Species Human (Homo sapiens) [TaxId:9606] [89180] (1 PDB entry)
    2. 548137Species Mouse (Mus musculus) [TaxId:10090] [48748] (1 PDB entry)
  16. 548139Myelin membrane adhesion molecule P0 [48728] (1 species)
  17. 548142Myelin oligodendrocyte glycoprotein (MOG) [89174] (1 species)
  18. 548148N-terminal domain of sialic acid binding Ig-like lectin 7 (SIGLEC-7, p75/AIRM1) [89176] (1 species)
  19. 548153N-terminal domain of sialoadhesin [48732] (1 species)
  20. 548163NK cell activating receptor NKP44 [89178] (1 species)
    a triggering partner in natural cytotoxicity
  21. 548166Novel antigen receptor (against lysozyme) [110042] (1 species)
  22. 548171Novel antigen receptor 12Y-1 [110044] (1 species)
  23. 548174Novel antigen receptor 12Y-2 [110046] (1 species)
  24. 548178Polymeric-immunoglobulin receptor, PIGR [117038] (1 species)
  25. 548186Programmed cell death protein 1, PD1, extracellular domain [101510] (1 species)
  26. 548189T-cell antigen receptor [48933] (6 species)
    sequences may differ within each classified species
    1. 548190Species Human (Homo sapiens), alpha-chain [TaxId:9606] [48935] (10 PDB entries)
    2. 548201Species Human (Homo sapiens), beta-chain [TaxId:9606] [48937] (11 PDB entries)
    3. 548214Species Human (Homo sapiens), delta-chain [TaxId:9606] [48938] (2 PDB entries)
    4. 548221Species Human (Homo sapiens), gamma-chain [TaxId:9606] [63651] (1 PDB entry)
    5. 548226Species Mouse (Mus musculus), alpha-chain [TaxId:10090] [48934] (16 PDB entries)
    6. 548255Species Mouse (Mus musculus), beta-chain [TaxId:10090] [48936] (17 PDB entries)
  27. 548284TREM-1 (triggering receptor expressed on myeloid cells 1) [101506] (2 species)
    1. 548285Species Human (Homo sapiens) [TaxId:9606] [101507] (2 PDB entries)
    2. 548292Species Mouse (Mus musculus) [TaxId:10090] [117037] (1 PDB entry)
  28. 548295Tyrosine-protein kinase receptor tyro3, N-terminal domain [101508] (1 species)

More info for Family b.1.1.1: V set domains (antibody variable domain-like)

Timeline for Family b.1.1.1: V set domains (antibody variable domain-like):