Lineage for Protein: Snake phospholipase A2

  1. Root: SCOP 1.67
  2. 349259Class a: All alpha proteins [46456] (202 folds)
  3. 361220Fold a.133: Phospholipase A2, PLA2 [48618] (1 superfamily)
    common core: 2 helices, disulfide-linked, and a calcium-binding loop
  4. 361221Superfamily a.133.1: Phospholipase A2, PLA2 [48619] (3 families) (S)
  5. 361226Family a.133.1.2: Vertebrate phospholipase A2 [48623] (2 proteins)
  6. 361305Protein Snake phospholipase A2 [48624] (33 species)

Species:

  1. 361306Bothrops godmani [48645] (1 PDB entry)
    Monomeric Lys-49 phospholipase A2 homologue
  2. 361308Bothrops pirajai, Piratoxin-II (PRTX-II) [TaxId:113192] [48633] (1 PDB entry)
  3. 361311Broad-banded copperhead (Agkistrodon contortrix laticinctus) [TaxId:37195] [101483] (3 PDB entries)
    1. Domain for 1s8g:
    2. Domain for 1s8h:
    3. Domain for 1s8i:
  4. 361315Chinese water moccasin (Agkistrodon halys pallas), different isoforms [48628] (9 PDB entries)
    1. Domains for 1a2a:
      1. 361336Domain d1a2aa_: 1a2a A: [19540]
      2. 361337Domain d1a2ab_: 1a2a B: [19541]
      3. 361338Domain d1a2ac_: 1a2a C: [19542]
      4. 361339Domain d1a2ad_: 1a2a D: [19543]
      5. 361340Domain d1a2ae_: 1a2a E: [19544]
      6. 361341Domain d1a2af_: 1a2a F: [19545]
      7. 361342Domain d1a2ag_: 1a2a G: [19546]
      8. 361343Domain d1a2ah_: 1a2a H: [19547]
        complexed with cl
    2. Domains for 1b4w:
      1. 361322Domain d1b4wa_: 1b4w A: [19536]
      2. 361323Domain d1b4wb_: 1b4w B: [19537]
      3. 361324Domain d1b4wc_: 1b4w C: [19538]
      4. 361325Domain d1b4wd_: 1b4w D: [19539]
    3. Domains for 1bjj:
      1. 361326Domain d1bjja_: 1bjj A: [19530]
      2. 361327Domain d1bjjb_: 1bjj B: [19531]
      3. 361328Domain d1bjjc_: 1bjj C: [19532]
      4. 361329Domain d1bjjd_: 1bjj D: [19533]
      5. 361330Domain d1bjje_: 1bjj E: [19534]
      6. 361331Domain d1bjjf_: 1bjj F: [19535]
        complexed with ca
    4. Domain for 1bk9:
    5. Domains for 1c1j:
      1. 361332Domain d1c1ja_: 1c1j A: [70061]
      2. 361333Domain d1c1jb_: 1c1j B: [70062]
      3. 361334Domain d1c1jc_: 1c1j C: [70063]
      4. 361335Domain d1c1jd_: 1c1j D: [70064]
        complexed with bog, cd
    6. Domains for 1jia:
      1. 361320Domain d1jiaa_: 1jia A: [19528]
      2. 361321Domain d1jiab_: 1jia B: [19529]
        complexed with ca
    7. Domain for 1m8r:
    8. Domain for 1m8s:
    9. Domain for 1psj:
  5. 361344Eastern cottonmouth snake (Agkistridon piscivorus) [48629] (2 PDB entries)
    1. Domain for 1ppa:
    2. Domains for 1vap:
      1. 361345Domain d1vapa_: 1vap A: [19548]
      2. 361346Domain d1vapb_: 1vap B: [19549]
  6. 361348Hundred-pace snake (Agkistrodon acutus) [TaxId:36307] [74796] (2 PDB entries)
    monomeric Lys-49 phospholipase A2 homologue
    1. Domain for 1mc2:
    2. Domain for 1mg6:
  7. 361351Indian cobra (Naja naja naja) [48626] (3 PDB entries)
    1. Domain for 1a3d:
    2. Domains for 1a3f:
      1. 361356Domain d1a3fa_: 1a3f A: [19521]
      2. 361357Domain d1a3fb_: 1a3f B: [19522]
      3. 361358Domain d1a3fc_: 1a3f C: [19523]
    3. Domains for 1psh:
      1. 361353Domain d1psha_: 1psh A: [19518]
      2. 361354Domain d1pshb_: 1psh B: [19519]
      3. 361355Domain d1pshc_: 1psh C: [19520]
        complexed with ca
  8. 361359Indian cobra (Naja naja sagittifera), acidic isoform 1 [TaxId:195058] [89168] (1 PDB entry)
  9. 361361Indian cobra (Naja naja sagittifera), calcium-free isoform 5 [TaxId:195058] [89172] (2 PDB entries)
    1. Domain for 1mh7:
    2. Domain for 1mh8:
      • 361362Domain d1mh8a_: 1mh8 A: [84963]
        possibly another isoform with isoleucine at second position
  10. 361364Indian cobra (Naja naja sagittifera), isoform 2 [TaxId:195058] [89169] (2 PDB entries)
    heterodimer of two different isoforms
    1. Domain for 1mh2:
      • 361366Domain d1mh2a_: 1mh2 A: [84960]
        zinc containing heterodimer of two different isoforms
        complexed with acy, zn
    2. Domain for 1s6b:
      • 361365Domain d1s6ba_: 1s6b A: [98592]
        heterodimer of two different isoforms
        complexed with acy, ca, po4
  11. 361367Indian cobra (Naja naja sagittifera), isoform 3 [TaxId:195058] [89170] (2 PDB entries)
    heterodimer of two different isoforms
    1. Domain for 1mh2:
      • 361369Domain d1mh2b_: 1mh2 B: [84961]
        zinc containing heterodimer of two different isoforms
        complexed with acy, zn
    2. Domain for 1s6b:
      • 361368Domain d1s6bb_: 1s6b B: [98593]
        heterodimer of two different isoforms
        complexed with acy, ca, po4
  12. 361370Indian cobra (Naja naja sagittifera), isoform 4 [TaxId:195058] [89171] (4 PDB entries)
    1. Domain for 1ln8:
    2. Domain for 1mf4:
      • 361372Domain d1mf4a_: 1mf4 A: [91261]
        complexed with a designed peptide inhibitor
        complexed with ca
    3. Domain for 1oxr:
    4. Domain for 1t37:
  13. 361375Indian cobra (Naja naja), a C49 isoform 2 [TaxId:35670] [89166] (1 PDB entry)
    • Domain for 1ows:
      • 361376Domain d1owsa_: 1ows A: [87491]
        zinc containing heterodimer of two different isoforms
        complexed with nag, zn
  14. 361377Indian cobra (Naja naja), isoform 3 [TaxId:35670] [89167] (1 PDB entry)
    • Domain for 1ows:
      • 361378Domain d1owsb_: 1ows B: [87492]
        zinc containing heterodimer of two different isoforms
        complexed with nag, zn
  15. 361379Indian krait (Bungarus caeruleus), different isoforms [TaxId:132961] [48636] (5 PDB entries)
    1. Domain for 1dpy:
    2. Domain for 1fe5:
    3. Domains for 1g0z:
      1. 361380Domain d1g0za_: 1g0z A: [83263]
      2. 361381Domain d1g0zb_: 1g0z B: [83264]
        complexed with cl; mutant
    4. Domains for 1g2x:
      1. 361384Domain d1g2xa_: 1g2x A: [83265]
      2. 361385Domain d1g2xb_: 1g2x B: [83266]
      3. 361386Domain d1g2xc_: 1g2x C: [83267]
        trimeric isoform
    5. Domain for 1po8:
  16. 361388Jararacussu (Bothrops jararacussu) [TaxId:8726] [101487] (1 PDB entry)
    • Domain for 1umv:
      • 361389Domain d1umvx_: 1umv X: [99630]
        acidic, non-myotoxic phospholipase A2
        complexed with ca
  17. 361390King cobra (Ophiophagus hannah) [TaxId:8665] [81939] (1 PDB entry)
  18. 361394King cobra (Ophiophagus hannah), an acidic isoform [TaxId:8665] [101482] (1 PDB entry)
  19. 361401Mainland tiger snake (Notechis scutatus scutatus), notechis II-5 [TaxId:8663] [48632] (1 PDB entry)
    neurotoxic phospholipase a2
  20. 361404Mainland tiger snake (Notechis scutatus scutatus), notexin [TaxId:8663] [48631] (1 PDB entry)
    presynaptic neurotoxic phospholipase A2
  21. 361406Many-banded krait (Bungarus multicinctus), beta2-bungarotoxin [TaxId:8616] [48642] (1 PDB entry)
  22. 361408Russell's viper (Vipera russelli) [TaxId:8707] [48634] (1 PDB entry)
    anticoagulant class II phospholipase A2
  23. 361410Sand viper (Vipera ammodytes meridionalis), vipoxin catalytic subunit [TaxId:8704] [88518] (2 PDB entries)
    1. Domain for 1aok:
      • 361412Domain d1aokb_: 1aok B: [19561]
        complex with inhibitory subunit
        complexed with act
    2. Domain for 1jlt:
      • 361411Domain d1jltb_: 1jlt B: [66868]
        complex with inhibitory subunit
        complexed with mpd
  24. 361413Sand viper (Vipera ammodytes meridionalis), vipoxin inhibitor [TaxId:8704] [88517] (4 PDB entries)
    1. Domain for 1aok:
      • 361416Domain d1aoka_: 1aok A: [19560]
        complex with catalytic subunit
        complexed with act
    2. Domain for 1jlt:
      • 361414Domain d1jlta_: 1jlt A: [66867]
        complex with catalytic subunit
        complexed with mpd
    3. Domains for 1q5t:
      1. 361417Domain d1q5ta_: 1q5t A: [95932]
      2. 361418Domain d1q5tb_: 1q5t B: [95933]
        complexed with so4
    4. Domain for 1vpi:
  25. 361419Saw-scaled viper (Echis carinatus) [TaxId:40353] [101486] (1 PDB entry)
  26. 361421Siamese russell's viper (Daboia russelli siamensis), RV4 catalytic subunit [TaxId:343250] [101485] (1 PDB entry)
  27. 361426Siamese russell's viper (Daboia russelli siamensis), RV7 inhibitory subunit [TaxId:343250] [101484] (1 PDB entry)
  28. 361431Snake (Bothrops pirajai), piratoxin III [TaxId:113192] [69123] (1 PDB entry)
    Asp-49 phospholipase A2 homologue
  29. 361434Snake (Daboia russelli pulchella) [48630] (15 PDB entries)
    1. Domains for 1cl5:
      1. 361453Domain d1cl5a_: 1cl5 A: [19551]
      2. 361454Domain d1cl5b_: 1cl5 B: [19552]
        complexed with vitamin E
    2. Domains for 1fb2:
      1. 361451Domain d1fb2a_: 1fb2 A: [59758]
      2. 361452Domain d1fb2b_: 1fb2 B: [59759]
    3. Domains for 1fv0:
      1. 361439Domain d1fv0a_: 1fv0 A: [70147]
      2. 361440Domain d1fv0b_: 1fv0 B: [70148]
        complexed with aristolochic acid
        complexed with 9ar, act, cry, dox, so4
    4. Domains for 1jq8:
      1. 361449Domain d1jq8a_: 1jq8 A: [77147]
      2. 361450Domain d1jq8b_: 1jq8 B: [77148]
        complexed with a designed peptide inhibitor, chain P
        complexed with acy, so4
    5. Domains for 1jq9:
      1. 361444Domain d1jq9a_: 1jq9 A: [77149]
      2. 361445Domain d1jq9b_: 1jq9 B: [77150]
        complexed with a designed peptide inhibitor, chain P
        complexed with acy
    6. Domains for 1kpm:
      1. 361446Domain d1kpma_: 1kpm A: [72844]
      2. 361447Domain d1kpmb_: 1kpm B: [72845]
        complexed with vitamin E
        complexed with acy, vit
    7. Domains for 1oxl:
      1. 361442Domain d1oxla_: 1oxl A: [93702]
      2. 361443Domain d1oxlb_: 1oxl B: [93703]
        complexed with co3, ida, so4
    8. Domains for 1oyf:
      1. 361455Domain d1oyfa_: 1oyf A: [87595]
      2. 361456Domain d1oyfb_: 1oyf B: [87596]
        complexed with acy, mhn, so4
    9. Domain for 1q6v:
    10. Domain for 1q7a:
    11. Domain for 1skg:
    12. Domain for 1sqz:
    13. Domain for 1sv3:
    14. Domain for 1sv9:
    15. Domain for 1sxk:
  30. 361458Taiwan cobra (Naja naja atra) [TaxId:8656] [48625] (2 PDB entries)
    1. Domain for 1poa:
    2. Domains for 1pob:
      1. 361460Domain d1poba_: 1pob A: [19515]
      2. 361461Domain d1pobb_: 1pob B: [19516]
        complexed with ca, gel
  31. 361462Terciopelo (Bothrops asper), myotoxin I [TaxId:8722] [48644] (1 PDB entry)
  32. 361465Viper (Deinagkistrodon acutus) [TaxId:36307] [69122] (1 PDB entry)
  33. 361468Western diamondback rattlesnake (Crotalus atrox) [TaxId:8730] [48627] (1 PDB entry)

More info for Protein Snake phospholipase A2 from a.133.1.2: Vertebrate phospholipase A2

Timeline for Protein Snake phospholipase A2 from a.133.1.2: Vertebrate phospholipase A2: