Lineage for Protein: Snake phospholipase A2

  1. Root: SCOP 1.65
  2. 275720Class a: All alpha proteins [46456] (179 folds)
  3. 286043Fold a.133: Phospholipase A2, PLA2 [48618] (1 superfamily)
    common core: 2 helices, disulphide-linked, and a calcium-binding loop
  4. 286044Superfamily a.133.1: Phospholipase A2, PLA2 [48619] (3 families) (S)
  5. 286049Family a.133.1.2: Vertebrate phospholipase A2 [48623] (2 proteins)
  6. 286123Protein Snake phospholipase A2 [48624] (27 species)

Species:

  1. 286124Bothrops godmani [48645] (1 PDB entry)
    Monomeric Lys-49 phospholipase A2 homologue
  2. 286126Bothrops pirajai, Piratoxin-II (PRTX-II) [TaxId:113192] [48633] (1 PDB entry)
  3. 286129Chinese water moccasin (Agkistrodon halys pallas), different isoforms [48628] (9 PDB entries)
    1. Domains for 1a2a:
      1. 286150Domain d1a2aa_: 1a2a A: [19540]
      2. 286151Domain d1a2ab_: 1a2a B: [19541]
      3. 286152Domain d1a2ac_: 1a2a C: [19542]
      4. 286153Domain d1a2ad_: 1a2a D: [19543]
      5. 286154Domain d1a2ae_: 1a2a E: [19544]
      6. 286155Domain d1a2af_: 1a2a F: [19545]
      7. 286156Domain d1a2ag_: 1a2a G: [19546]
      8. 286157Domain d1a2ah_: 1a2a H: [19547]
        complexed with cl
    2. Domains for 1b4w:
      1. 286136Domain d1b4wa_: 1b4w A: [19536]
      2. 286137Domain d1b4wb_: 1b4w B: [19537]
      3. 286138Domain d1b4wc_: 1b4w C: [19538]
      4. 286139Domain d1b4wd_: 1b4w D: [19539]
    3. Domains for 1bjj:
      1. 286140Domain d1bjja_: 1bjj A: [19530]
      2. 286141Domain d1bjjb_: 1bjj B: [19531]
      3. 286142Domain d1bjjc_: 1bjj C: [19532]
      4. 286143Domain d1bjjd_: 1bjj D: [19533]
      5. 286144Domain d1bjje_: 1bjj E: [19534]
      6. 286145Domain d1bjjf_: 1bjj F: [19535]
        complexed with ca
    4. Domain for 1bk9:
    5. Domains for 1c1j:
      1. 286146Domain d1c1ja_: 1c1j A: [70061]
      2. 286147Domain d1c1jb_: 1c1j B: [70062]
      3. 286148Domain d1c1jc_: 1c1j C: [70063]
      4. 286149Domain d1c1jd_: 1c1j D: [70064]
        complexed with bog, cd
    6. Domains for 1jia:
      1. 286134Domain d1jiaa_: 1jia A: [19528]
      2. 286135Domain d1jiab_: 1jia B: [19529]
        complexed with ca
    7. Domain for 1m8r:
    8. Domain for 1m8s:
    9. Domain for 1psj:
  4. 286158Eastern cottonmouth snake (Agkistridon piscivorus) [48629] (2 PDB entries)
    1. Domain for 1ppa:
    2. Domains for 1vap:
      1. 286159Domain d1vapa_: 1vap A: [19548]
      2. 286160Domain d1vapb_: 1vap B: [19549]
  5. 286162Hundred-pace snake (Agkistrodon acutus) [TaxId:36307] [74796] (2 PDB entries)
    monomeric Lys-49 phospholipase A2 homologue
    1. Domain for 1mc2:
    2. Domain for 1mg6:
  6. 286165Indian cobra (Naja naja naja) [48626] (3 PDB entries)
    1. Domain for 1a3d:
    2. Domains for 1a3f:
      1. 286170Domain d1a3fa_: 1a3f A: [19521]
      2. 286171Domain d1a3fb_: 1a3f B: [19522]
      3. 286172Domain d1a3fc_: 1a3f C: [19523]
    3. Domains for 1psh:
      1. 286167Domain d1psha_: 1psh A: [19518]
      2. 286168Domain d1pshb_: 1psh B: [19519]
      3. 286169Domain d1pshc_: 1psh C: [19520]
        complexed with ca
  7. 286173Indian cobra (Naja naja sagittifera), acidic isoform 1 [TaxId:195058] [89168] (1 PDB entry)
  8. 286175Indian cobra (Naja naja sagittifera), calcium-free isoform 5 [TaxId:195058] [89172] (2 PDB entries)
    1. Domain for 1mh7:
    2. Domain for 1mh8:
      • 286176Domain d1mh8a_: 1mh8 A: [84963]
        possibly another isoform with isoleucine at second position
  9. 286178Indian cobra (Naja naja sagittifera), isoform 2 [TaxId:195058] [89169] (2 PDB entries)
    1. Domain for 1lfj:
      • 286179Domain d1lfja_: 1lfj A: [84604]
        heterodimer of two different isoforms
        complexed with acy, ca, po4
    2. Domain for 1mh2:
      • 286180Domain d1mh2a_: 1mh2 A: [84960]
        zinc containing heterodimer of two different isoforms
        complexed with acy, zn
  10. 286181Indian cobra (Naja naja sagittifera), isoform 3 [TaxId:195058] [89170] (2 PDB entries)
    1. Domain for 1lfj:
      • 286182Domain d1lfjb_: 1lfj B: [84605]
        heterodimer of two different isoforms
        complexed with acy, ca, po4
    2. Domain for 1mh2:
      • 286183Domain d1mh2b_: 1mh2 B: [84961]
        zinc containing heterodimer of two different isoforms
        complexed with acy, zn
  11. 286184Indian cobra (Naja naja sagittifera), isoform 4 [TaxId:195058] [89171] (1 PDB entry)
  12. 286186Indian cobra (Naja naja), a C49 isoform 2 [TaxId:35670] [89166] (1 PDB entry)
    • Domain for 1ows:
      • 286187Domain d1owsa_: 1ows A: [87491]
        zinc containing heterodimer of two different isoforms
        complexed with nag, zn
  13. 286188Indian cobra (Naja naja), isoform 3 [TaxId:35670] [89167] (1 PDB entry)
    • Domain for 1ows:
      • 286189Domain d1owsb_: 1ows B: [87492]
        zinc containing heterodimer of two different isoforms
        complexed with nag, zn
  14. 286190Indian krait (Bungarus caeruleus), different isoforms [TaxId:132961] [48636] (4 PDB entries)
    1. Domain for 1dpy:
    2. Domain for 1fe5:
    3. Domains for 1g0z:
      1. 286191Domain d1g0za_: 1g0z A: [83263]
      2. 286192Domain d1g0zb_: 1g0z B: [83264]
        complexed with cl; mutant
    4. Domains for 1g2x:
      1. 286195Domain d1g2xa_: 1g2x A: [83265]
      2. 286196Domain d1g2xb_: 1g2x B: [83266]
      3. 286197Domain d1g2xc_: 1g2x C: [83267]
        trimeric isoform
  15. 286198King cobra (Ophiophagus hannah) [TaxId:8665] [81939] (1 PDB entry)
  16. 286202Mainland tiger snake (Notechis scutatus scutatus), notechis II-5 [TaxId:8663] [48632] (1 PDB entry)
    neurotoxic phospholipase a2
  17. 286205Mainland tiger snake (Notechis scutatus scutatus), notexin [TaxId:8663] [48631] (1 PDB entry)
    presynaptic neurotoxic phospholipase A2
  18. 286207Many-banded krait (Bungarus multicinctus), beta2-bungarotoxin [TaxId:8616] [48642] (1 PDB entry)
  19. 286209Russell's viper (Vipera russelli) [TaxId:8707] [48634] (1 PDB entry)
    anticoagulant class II phospholipase A2
  20. 286211Sand viper (Vipera ammodytes meridionalis), vipoxin catalytic subunit [TaxId:8704] [88518] (2 PDB entries)
    1. Domain for 1aok:
      • 286213Domain d1aokb_: 1aok B: [19561]
        complex with inhibitory subunit
        complexed with act
    2. Domain for 1jlt:
      • 286212Domain d1jltb_: 1jlt B: [66868]
        complex with inhibitory subunit
        complexed with mpd
  21. 286214Sand viper (Vipera ammodytes meridionalis), vipoxin inhibitor [TaxId:8704] [88517] (3 PDB entries)
    1. Domain for 1aok:
      • 286217Domain d1aoka_: 1aok A: [19560]
        complex with catalytic subunit
        complexed with act
    2. Domain for 1jlt:
      • 286215Domain d1jlta_: 1jlt A: [66867]
        complex with catalytic subunit
        complexed with mpd
    3. Domain for 1vpi:
  22. 286218Snake (Bothrops pirajai), piratoxin III [TaxId:113192] [69123] (1 PDB entry)
    Asp-49 phospholipase A2 homologue
  23. 286221Snake (Daboia russelli pulchella) [48630] (7 PDB entries)
    1. Domains for 1cl5:
      1. 286232Domain d1cl5a_: 1cl5 A: [19551]
      2. 286233Domain d1cl5b_: 1cl5 B: [19552]
        complexed with vitamin E
    2. Domains for 1fb2:
      1. 286230Domain d1fb2a_: 1fb2 A: [59758]
      2. 286231Domain d1fb2b_: 1fb2 B: [59759]
    3. Domains for 1fv0:
      1. 286222Domain d1fv0a_: 1fv0 A: [70147]
      2. 286223Domain d1fv0b_: 1fv0 B: [70148]
        complexed with aristolochic acid
        complexed with 9ar, act, cry, dox, so4
    4. Domains for 1jq8:
      1. 286228Domain d1jq8a_: 1jq8 A: [77147]
      2. 286229Domain d1jq8b_: 1jq8 B: [77148]
        complexed with a designed peptide inhibitor, chain P
        complexed with acy, so4
    5. Domains for 1jq9:
      1. 286224Domain d1jq9a_: 1jq9 A: [77149]
      2. 286225Domain d1jq9b_: 1jq9 B: [77150]
        complexed with a designed peptide inhibitor, chain P
        complexed with acy
    6. Domains for 1kpm:
      1. 286226Domain d1kpma_: 1kpm A: [72844]
      2. 286227Domain d1kpmb_: 1kpm B: [72845]
        complexed with vitamin E
        complexed with acy, vit
    7. Domains for 1oyf:
      1. 286234Domain d1oyfa_: 1oyf A: [87595]
      2. 286235Domain d1oyfb_: 1oyf B: [87596]
        complexed with acy, mhn, so4
  24. 286236Taiwan cobra (Naja naja atra) [TaxId:8656] [48625] (2 PDB entries)
    1. Domain for 1poa:
    2. Domains for 1pob:
      1. 286238Domain d1poba_: 1pob A: [19515]
      2. 286239Domain d1pobb_: 1pob B: [19516]
        complexed with ca, gel
  25. 286240Terciopelo (Bothrops asper), myotoxin I [TaxId:8722] [48644] (1 PDB entry)
  26. 286243Viper (Deinagkistrodon acutus) [TaxId:36307] [69122] (1 PDB entry)
  27. 286246Western diamondback rattlesnake (Crotalus atrox) [TaxId:8730] [48627] (1 PDB entry)

More info for Protein Snake phospholipase A2 from a.133.1.2: Vertebrate phospholipase A2

Timeline for Protein Snake phospholipase A2 from a.133.1.2: Vertebrate phospholipase A2: