Lineage for Family a.133.1.2: Vertebrate phospholipase A2

  1. Root: SCOPe 2.01
  2. 901761Class a: All alpha proteins [46456] (284 folds)
  3. 925252Fold a.133: Phospholipase A2, PLA2 [48618] (1 superfamily)
    common core: 2 helices, disulfide-linked, and a calcium-binding loop
  4. 925253Superfamily a.133.1: Phospholipase A2, PLA2 [48619] (3 families) (S)
  5. 925258Family a.133.1.2: Vertebrate phospholipase A2 [48623] (3 proteins)

Proteins:

  1. 925259Phospholipase A2 [48637] (5 species)
    1. 925260Species Cow (Bos taurus), pancreas [TaxId:9913] [48639] (32 PDB entries)
      Uniprot P00593
    2. 925294Species Human (Homo sapiens) [TaxId:9606] [188854] (1 PDB entry)
    3. 925296Species Human (Homo sapiens), SPLA2 [TaxId:9606] [74797] (2 PDB entries)
      group X secretory phospholipase A2
    4. 925302Species Human (Homo sapiens), synovial fluid [TaxId:9606] [48638] (12 PDB entries)
    5. 925328Species Pig (Sus scrofa), pancreas [TaxId:9823] [48640] (20 PDB entries)
  2. 925358Snake phospholipase A2 [48624] (35 species)
    1. 925359Species Andaman cobra (Naja sagittifera), acidic isoform 1 [TaxId:195058] [89168] (1 PDB entry)
    2. 925361Species Andaman cobra (Naja sagittifera), calcium-free isoform 5 [TaxId:195058] [89172] (2 PDB entries)
    3. 925364Species Andaman cobra (Naja sagittifera), isoform 2 [TaxId:195058] [89169] (4 PDB entries)
      heterodimer of two different isoforms
    4. 925369Species Andaman cobra (Naja sagittifera), isoform 3 [TaxId:195058] [89170] (4 PDB entries)
      heterodimer of two different isoforms
    5. 925374Species Andaman cobra (Naja sagittifera), isoform 4 [TaxId:195058] [89171] (14 PDB entries)
      Uniprot P60045 8-126 # ! yet another isoform, 98% identity
    6. 925389Species Bothrops pirajai, Piratoxin-II (PRTX-II) [TaxId:113192] [48633] (3 PDB entries)
    7. 925396Species Broad-banded copperhead (Agkistrodon contortrix laticinctus) [TaxId:37195] [101483] (3 PDB entries)
    8. 925400Species Cerrophidion godmani, formerly Bothrops godmani [TaxId:44722] [48645] (1 PDB entry)
      Monomeric Lys-49 phospholipase A2 homologue
    9. 925402Species Eastern cottonmouth snake (Agkistrodon piscivorus piscivorus) [TaxId:8716] [48629] (2 PDB entries)
    10. 925406Species Hundred-pace snake (Agkistrodon acutus) [TaxId:36307] [74796] (2 PDB entries)
      monomeric Lys-49 phospholipase A2 homologue
    11. 925409Species Indian cobra (Naja naja) [TaxId:35670] [48626] (3 PDB entries)
    12. 925417Species Indian cobra (Naja naja), a C49 isoform 2 [TaxId:35670] [89166] (1 PDB entry)
    13. 925419Species Indian cobra (Naja naja), isoform 3 [TaxId:35670] [89167] (1 PDB entry)
    14. 925421Species Indian krait (Bungarus caeruleus), different isoforms [TaxId:132961] [48636] (7 PDB entries)
      Uniprot Q6SLM1 # fragment; Uniprot Q9DF52 28-145 # ! 74% sequence identity
    15. 925433Species Jararacussu (Bothrops jararacussu) [TaxId:8726] [101487] (8 PDB entries)
      Uniprot Q8AXY1 17-138
    16. 925447Species King cobra (Ophiophagus hannah) [TaxId:8665] [81939] (1 PDB entry)
    17. 925451Species King cobra (Ophiophagus hannah), an acidic isoform [TaxId:8665] [101482] (1 PDB entry)
    18. 925458Species Mainland tiger snake (Notechis scutatus scutatus), notechis II-5 [TaxId:8663] [48632] (1 PDB entry)
      neurotoxic phospholipase a2
    19. 925461Species Mainland tiger snake (Notechis scutatus scutatus), notexin [TaxId:8663] [48631] (1 PDB entry)
      presynaptic neurotoxic phospholipase A2
    20. 925463Species Many-banded krait (Bungarus multicinctus), beta2-bungarotoxin [TaxId:8616] [48642] (1 PDB entry)
    21. 925465Species Neuwied's lancehead (Bothrops neuwiedi pauloensis), different isoforms [TaxId:95649] [110032] (3 PDB entries)
    22. 925472Species Russell's viper (Vipera russelli) [TaxId:8707] [48634] (1 PDB entry)
      anticoagulant class II phospholipase A2
    23. 925474Species Sand viper (Vipera ammodytes meridionalis), vipoxin catalytic subunit [TaxId:8704] [88518] (2 PDB entries)
    24. 925477Species Sand viper (Vipera ammodytes meridionalis), vipoxin inhibitor [TaxId:8704] [88517] (5 PDB entries)
    25. 925487Species Saw-scaled viper (Echis carinatus) [TaxId:40353] [101486] (1 PDB entry)
    26. 925489Species Sharp-nosed viper (Deinagkistrodon acutus) [TaxId:36307] [69122] (1 PDB entry)
    27. 925492Species Siamese russell's viper (Daboia russelli siamensis), RV4 catalytic subunit [TaxId:343250] [101485] (1 PDB entry)
    28. 925497Species Siamese russell's viper (Daboia russelli siamensis), RV7 inhibitory subunit [TaxId:343250] [101484] (1 PDB entry)
    29. 925502Species Small-eye snake (Micropechis ikaheka), different isoforms [TaxId:66188] [110033] (2 PDB entries)
      Uniprot Q8JFB2 # 65% sequence identity
    30. 925511Species Snake (Agkistrodon halys) [TaxId:8714] [48628] (9 PDB entries)
    31. 925540Species Snake (Bothrops pirajai), piratoxin III [TaxId:113192] [69123] (1 PDB entry)
      Uniprot Q9IAT9; Asp-49 phospholipase A2 homologue
    32. 925543Species Snake (Daboia russellii pulchella), different isoforms [TaxId:97228] [48630] (28 PDB entries)
      Uniprot P59071
    33. 925584Species Taiwan cobra (Naja naja atra) [TaxId:8656] [48625] (2 PDB entries)
    34. 925588Species Terciopelo (Bothrops asper), myotoxin I [TaxId:8722] [48644] (2 PDB entries)
    35. 925593Species Western diamondback rattlesnake (Crotalus atrox) [TaxId:8730] [48627] (1 PDB entry)
  3. 925596automated matches [190139] (19 species)
    not a true protein
    1. 925597Species Atropoides nummifer [TaxId:44730] [187413] (1 PDB entry)
    2. 925599Species Bothrops moojeni [TaxId:98334] [188126] (1 PDB entry)
    3. 925602Species Bothrops pirajai [TaxId:113192] [188615] (1 PDB entry)
    4. 925605Species Bungarus caeruleus [TaxId:132961] [187166] (1 PDB entry)
    5. 925607Species Chinese cobra (Naja atra) [TaxId:8656] [187966] (1 PDB entry)
    6. 925609Species Crotalus durissus [TaxId:8732] [188410] (2 PDB entries)
    7. 925615Species Daboia russelli [TaxId:97228] [188715] (1 PDB entry)
    8. 925617Species Daboia russellii [TaxId:31159] [188906] (1 PDB entry)
    9. 925619Species Daboia russellii [TaxId:343250] [187787] (1 PDB entry)
    10. 925628Species Daboia russellii [TaxId:97228] [186865] (26 PDB entries)
    11. 925656Species Indian cobra (Naja naja) [TaxId:35670] [189291] (1 PDB entry)
    12. 925658Species Jararacussu (Bothrops jararacussu) [TaxId:8726] [186913] (7 PDB entries)
    13. 925671Species Micropechis ikaheka [TaxId:66188] [188000] (1 PDB entry)
    14. 925676Species Naja sagittifera [TaxId:195058] [188129] (2 PDB entries)
    15. 925680Species Pig (Sus scrofa) [TaxId:9823] [186957] (8 PDB entries)
    16. 925692Species Saw-scaled viper (Echis carinatus) [TaxId:40353] [188231] (3 PDB entries)
    17. 925704Species Vipera ammodytes [TaxId:8705] [188519] (3 PDB entries)
    18. 925708Species Vipera nikolskii [TaxId:110206] [187834] (1 PDB entry)
    19. 925711Species Zhaoermia mangshanensis [TaxId:242058] [188379] (1 PDB entry)

More info for Family a.133.1.2: Vertebrate phospholipase A2

Timeline for Family a.133.1.2: Vertebrate phospholipase A2: