Lineage for Family a.133.1.2: Vertebrate phospholipase A2

  1. Root: SCOP 1.63
  2. 208553Class a: All alpha proteins [46456] (171 folds)
  3. 217995Fold a.133: Phospholipase A2, PLA2 [48618] (1 superfamily)
    common core: 2 helices, disulphide-linked, and a calcium-binding loop
  4. 217996Superfamily a.133.1: Phospholipase A2, PLA2 [48619] (3 families) (S)
  5. 218001Family a.133.1.2: Vertebrate phospholipase A2 [48623] (2 proteins)

Proteins:

  1. 218002Phospholipase A2 [48637] (4 species)
    1. 218003Species Cow (Bos taurus), pancreas [TaxId:9913] [48639] (21 PDB entries)
    2. 218025Species Human (Homo sapiens), SPLA2 [TaxId:9606] [74797] (2 PDB entries)
      group X secretory phospholipase A2
    3. 218031Species Human (Homo sapiens), synovial fluid [TaxId:9606] [48638] (8 PDB entries)
    4. 218051Species Pig (Sus scrofa), pancreas [TaxId:9823] [48640] (13 PDB entries)
  2. 218072Snake phospholipase A2 [48624] (19 species)
    1. 218073Species Bothrops godmani [48645] (1 PDB entry)
      Monomeric Lys-49 phospholipase A2 homologue
    2. 218075Species Bothrops pirajai, Piratoxin-II (PRTX-II) [TaxId:113192] [48633] (1 PDB entry)
    3. 218078Species Chinese water moccasin (Agkistrodon halys pallas), different isoforms [48628] (9 PDB entries)
    4. 218107Species Eastern cottonmouth snake (Agkistridon piscivorus) [48629] (2 PDB entries)
    5. 218111Species Hundred-pace snake (Agkistrodon acutus) [TaxId:36307] [74796] (2 PDB entries)
      monomeric Lys-49 phospholipase A2 homologue
    6. 218114Species Indian cobra (Naja naja naja) [48626] (3 PDB entries)
    7. 218122Species Indian krait (Bungarus caeruleus), different isoforms [TaxId:132961] [48636] (2 PDB entries)
    8. 218125Species King cobra (Ophiophagus hannah) [TaxId:8665] [81939] (1 PDB entry)
    9. 218129Species Mainland tiger snake (Notechis scutatus scutatus), notechis II-5 [TaxId:8663] [48632] (1 PDB entry)
      neurotoxic phospholipase a2
    10. 218132Species Mainland tiger snake (Notechis scutatus scutatus), notexin [TaxId:8663] [48631] (1 PDB entry)
      presynaptic neurotoxic phospholipase A2
    11. 218134Species Many-banded krait (Bungarus multicinctus), beta2-bungarotoxin [TaxId:8616] [48642] (1 PDB entry)
    12. 218136Species Russell's viper (Vipera russelli) [TaxId:8707] [48634] (1 PDB entry)
      anticoagulant class II phospholipase A2
    13. 218138Species Sand viper (Vipera ammodytes meridionalis), vipoxin [48635] (3 PDB entries)
      heterodimer of two homologous subunits, one is catalytic and the other is inhibitory
    14. 218144Species Snake (Bothrops pirajai), piratoxin III [TaxId:113192] [69123] (1 PDB entry)
      Asp-49 phospholipase A2 homologue
    15. 218147Species Snake (Daboia russelli pulchella) [48630] (6 PDB entries)
    16. 218160Species Taiwan cobra (Naja naja atra) [TaxId:8656] [48625] (2 PDB entries)
    17. 218164Species Terciopelo (Bothrops asper), myotoxin I [TaxId:8722] [48644] (1 PDB entry)
    18. 218167Species Viper (Deinagkistrodon acutus) [TaxId:36307] [69122] (1 PDB entry)
    19. 218170Species Western diamondback rattlesnake (Crotalus atrox) [TaxId:8730] [48627] (1 PDB entry)

More info for Family a.133.1.2: Vertebrate phospholipase A2

Timeline for Family a.133.1.2: Vertebrate phospholipase A2: