Lineage for Family a.133.1.2: Vertebrate phospholipase A2

  1. Root: SCOPe 2.07
  2. 2299346Class a: All alpha proteins [46456] (289 folds)
  3. 2338840Fold a.133: Phospholipase A2, PLA2 [48618] (1 superfamily)
    common core: 2 helices, disulfide-linked, and a calcium-binding loop
  4. 2338841Superfamily a.133.1: Phospholipase A2, PLA2 [48619] (4 families) (S)
  5. 2338846Family a.133.1.2: Vertebrate phospholipase A2 [48623] (3 proteins)
    automatically mapped to Pfam PF00068

Proteins:

  1. 2338847Phospholipase A2 [48637] (5 species)
    1. 2338848Species Cow (Bos taurus), pancreas [TaxId:9913] [48639] (32 PDB entries)
      Uniprot P00593
    2. 2338882Species Human (Homo sapiens) [TaxId:9606] [188854] (1 PDB entry)
    3. 2338884Species Human (Homo sapiens), SPLA2 [TaxId:9606] [74797] (5 PDB entries)
      group X secretory phospholipase A2
    4. 2338892Species Human (Homo sapiens), synovial fluid [TaxId:9606] [48638] (16 PDB entries)
    5. 2338925Species Pig (Sus scrofa), pancreas [TaxId:9823] [48640] (23 PDB entries)
  2. 2338958Snake phospholipase A2 [48624] (38 species)
    1. 2338959Species Andaman cobra (Naja sagittifera), acidic isoform 1 [TaxId:195058] [89168] (1 PDB entry)
    2. 2338961Species Andaman cobra (Naja sagittifera), calcium-free isoform 5 [TaxId:195058] [89172] (2 PDB entries)
    3. 2338964Species Andaman cobra (Naja sagittifera), isoform 2 [TaxId:195058] [89169] (4 PDB entries)
      heterodimer of two different isoforms
    4. 2338969Species Andaman cobra (Naja sagittifera), isoform 3 [TaxId:195058] [89170] (4 PDB entries)
      heterodimer of two different isoforms
    5. 2338974Species Andaman cobra (Naja sagittifera), isoform 4 [TaxId:195058] [89171] (14 PDB entries)
      Uniprot P60045 8-126 # ! yet another isoform, 98% identity
    6. 2338989Species Bothrops brazili [TaxId:157546] [228951] (1 PDB entry)
    7. 2338992Species Bothrops pauloensis [TaxId:1042543] [343230] (4 PDB entries)
    8. 2338997Species Bothrops pirajai, Piratoxin-II (PRTX-II) [TaxId:113192] [48633] (3 PDB entries)
    9. 2339004Species Broad-banded copperhead (Agkistrodon contortrix laticinctus) [TaxId:37195] [101483] (3 PDB entries)
    10. 2339008Species Cerrophidion godmani, formerly Bothrops godmani [TaxId:44722] [48645] (1 PDB entry)
      Monomeric Lys-49 phospholipase A2 homologue
    11. 2339010Species Eastern cottonmouth snake (Agkistrodon piscivorus piscivorus) [TaxId:8716] [48629] (2 PDB entries)
    12. 2339014Species Halys viper (Agkistrodon halys) [TaxId:8714] [48628] (9 PDB entries)
    13. 2339043Species Hundred-pace snake (Agkistrodon acutus) [TaxId:36307] [74796] (2 PDB entries)
      monomeric Lys-49 phospholipase A2 homologue
    14. 2339046Species Indian cobra (Naja naja) [TaxId:35670] [48626] (3 PDB entries)
    15. 2339054Species Indian cobra (Naja naja), a C49 isoform 2 [TaxId:35670] [89166] (1 PDB entry)
    16. 2339056Species Indian cobra (Naja naja), isoform 3 [TaxId:35670] [89167] (1 PDB entry)
    17. 2339058Species Indian krait (Bungarus caeruleus), different isoforms [TaxId:132961] [48636] (7 PDB entries)
      Uniprot Q6SLM1 # fragment; Uniprot Q9DF52 28-145 # ! 74% sequence identity
    18. 2339070Species Jararacussu (Bothrops jararacussu) [TaxId:8726] [101487] (9 PDB entries)
      Uniprot Q8AXY1 17-138
    19. 2339086Species King cobra (Ophiophagus hannah) [TaxId:8665] [81939] (1 PDB entry)
    20. 2339090Species King cobra (Ophiophagus hannah), an acidic isoform [TaxId:8665] [101482] (1 PDB entry)
    21. 2339097Species Mainland tiger snake (Notechis scutatus scutatus), notechis II-5 [TaxId:8663] [48632] (1 PDB entry)
      neurotoxic phospholipase a2
    22. 2339100Species Mainland tiger snake (Notechis scutatus scutatus), notexin [TaxId:8663] [48631] (2 PDB entries)
      presynaptic neurotoxic phospholipase A2
    23. 2339103Species Many-banded krait (Bungarus multicinctus), beta2-bungarotoxin [TaxId:8616] [48642] (1 PDB entry)
    24. 2339105Species Naja naja [311160] (1 PDB entry)
    25. 2339108Species Neuwied's lancehead (Bothrops neuwiedi pauloensis), different isoforms [TaxId:95649] [110032] (3 PDB entries)
    26. 2339115Species Russell's viper (Vipera russelli) [TaxId:8707] [48634] (1 PDB entry)
      anticoagulant class II phospholipase A2
    27. 2339117Species Sand viper (Vipera ammodytes meridionalis), vipoxin catalytic subunit [TaxId:8704] [88518] (2 PDB entries)
    28. 2339120Species Sand viper (Vipera ammodytes meridionalis), vipoxin inhibitor [TaxId:8704] [88517] (5 PDB entries)
    29. 2339130Species Saw-scaled viper (Echis carinatus) [TaxId:40353] [101486] (1 PDB entry)
    30. 2339132Species Sharp-nosed viper (Deinagkistrodon acutus) [TaxId:36307] [69122] (1 PDB entry)
    31. 2339135Species Siamese russell's viper (Daboia russelli siamensis), RV4 catalytic subunit [TaxId:343250] [101485] (1 PDB entry)
    32. 2339140Species Siamese russell's viper (Daboia russelli siamensis), RV7 inhibitory subunit [TaxId:343250] [101484] (1 PDB entry)
    33. 2339145Species Small-eye snake (Micropechis ikaheka), different isoforms [TaxId:66188] [110033] (2 PDB entries)
      Uniprot Q8JFB2 # 65% sequence identity
    34. 2339154Species Snake (Bothrops pirajai), piratoxin III [TaxId:113192] [69123] (1 PDB entry)
      Uniprot Q9IAT9; Asp-49 phospholipase A2 homologue
    35. 2339157Species Snake (Daboia russellii pulchella), different isoforms [TaxId:97228] [48630] (39 PDB entries)
      Uniprot P59071
    36. 2339206Species Taiwan cobra (Naja naja atra) [TaxId:8656] [48625] (2 PDB entries)
    37. 2339210Species Terciopelo (Bothrops asper), myotoxin I [TaxId:8722] [48644] (2 PDB entries)
    38. 2339215Species Western diamondback rattlesnake (Crotalus atrox) [TaxId:8730] [48627] (1 PDB entry)
  3. 2339218automated matches [190139] (26 species)
    not a true protein
    1. 2339219Species Atropoides nummifer [TaxId:44730] [187413] (1 PDB entry)
    2. 2339221Species Bothrops asper [TaxId:8722] [339854] (1 PDB entry)
    3. 2339224Species Bothrops brazili [TaxId:157546] [195180] (2 PDB entries)
    4. 2339231Species Bothrops moojeni [TaxId:98334] [188126] (9 PDB entries)
    5. 2339242Species Bothrops pirajai [TaxId:113192] [188615] (4 PDB entries)
    6. 2339251Species Bungarus caeruleus [TaxId:132961] [187166] (1 PDB entry)
    7. 2339253Species Chinese cobra (Naja atra) [TaxId:8656] [187966] (1 PDB entry)
    8. 2339255Species Crotalus durissus [TaxId:8732] [188410] (2 PDB entries)
    9. 2339261Species Daboia russelli [TaxId:97228] [188715] (1 PDB entry)
    10. 2339263Species Daboia russellii [TaxId:31159] [188906] (1 PDB entry)
    11. 2339265Species Daboia russellii [TaxId:343250] [187787] (1 PDB entry)
    12. 2339274Species Daboia russellii [TaxId:97228] [186865] (27 PDB entries)
    13. 2339306Species Halys viper (Agkistrodon halys) [TaxId:8714] [194477] (1 PDB entry)
    14. 2339311Species Human (Homo sapiens) [TaxId:9606] [260458] (11 PDB entries)
    15. 2339316Species Indian cobra (Naja naja) [TaxId:35670] [189291] (2 PDB entries)
    16. 2339319Species Jararacussu (Bothrops jararacussu) [TaxId:8726] [186913] (8 PDB entries)
    17. 2339332Species Micropechis ikaheka [TaxId:66188] [188000] (1 PDB entry)
    18. 2339337Species Naja sagittifera [TaxId:195058] [188129] (2 PDB entries)
    19. 2339341Species Pig (Sus scrofa) [TaxId:9823] [186957] (9 PDB entries)
    20. 2339354Species Pseudechis australis [TaxId:8670] [193996] (1 PDB entry)
    21. 2339357Species Saw-scaled viper (Echis carinatus) [TaxId:40353] [188231] (4 PDB entries)
    22. 2339377Species Vipera ammodytes [TaxId:73841] [195494] (1 PDB entry)
    23. 2339386Species Vipera ammodytes [TaxId:8705] [188519] (3 PDB entries)
    24. 2339390Species Vipera nikolskii [TaxId:110206] [187834] (1 PDB entry)
    25. 2339393Species Viridovipera stejnegeri [TaxId:39682] [194681] (3 PDB entries)
    26. 2339401Species Zhaoermia mangshanensis [TaxId:242058] [188379] (1 PDB entry)

More info for Family a.133.1.2: Vertebrate phospholipase A2

Timeline for Family a.133.1.2: Vertebrate phospholipase A2: