SCOPe 2.07: Family a.211.1.2: PDEase

Lineage for Family a.211.1.2: PDEase

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

Proteins:

1. Catalytic domain of cyclic nucleotide phosphodiesterase 1b, PDE1B [109944] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [109945] (1 PDB entry)
     Uniprot Q01064 126-482

2. Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b [48549] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [48550] (31 PDB entries)
     Uniprot Q07343 324-667

3. Catalytic domain of cyclic nucleotide phosphodiesterase pde4d [89151] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [89152] (72 PDB entries)
     Uniprot Q08499 388-713

4. cGMP-inhibited 3',5'-cyclic phosphodiesterase B, pde3b [101441] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [101442] (2 PDB entries)

5. cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx [101439] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [101440] (26 PDB entries)
     Uniprot O76074 534-860

6. High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, PDE9A [109942] (2 species)

   1. Species Chimpanzee (Pan troglodytes) [TaxId:9598] [261550] (1 PDB entry)

   2. Species Human (Homo sapiens) [TaxId:9606] [109943] (22 PDB entries)
      Uniprot O76083 241-566

7. automated matches [190370] (2 species)
   not a true protein

   1. Species Human (Homo sapiens) [TaxId:9606] [187208] (37 PDB entries)

   2. Species Schistosoma mansoni [TaxId:6183] [361055] (2 PDB entries)

More info for Family a.211.1.2: PDEase

Timeline for Family a.211.1.2: PDEase:

• Family a.211.1.2: PDEase first appeared (with stable ids) in SCOP 1.55, called Family a.125.1.1: Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
  
• Family a.211.1.2: PDEase appears in SCOPe 2.06
  
• Family a.211.1.2: PDEase appears in the current release, SCOPe 2.08