SCOP 1.73: Superfamily a.100.1: 6-phosphogluconate dehydrogenase C-terminal domain-like

Lineage for Superfamily a.100.1: 6-phosphogluconate dehydrogenase C-terminal domain-like

1. Root: SCOP 1.73

2. Class a: All alpha proteins [46456] (258 folds)

3. Fold a.100: 6-phosphogluconate dehydrogenase C-terminal domain-like [48178] (1 superfamily)
   multihelical; common core is formed around two long antiparallel helices related by (pseudo) twofold symmetry

4. Superfamily a.100.1: 6-phosphogluconate dehydrogenase C-terminal domain-like [48179] (12 families)
   N-terminal domain is Rossmann-fold with a family-specific C-terminal extension

Families:

1. a.100.1.1: Hydroxyisobutyrate and 6-phosphogluconate dehydrogenase domain [48180] (2 proteins)
   Hydroxyisobutyrate dehydrogenase domain is similar to one structural repeat in the 6-phosphogluconate dehydrogenase domain

2. a.100.1.2: Acetohydroxy acid isomeroreductase (ketol-acid reductoisomerase, KARI) [48184] (2 proteins)

3. a.100.1.3: HCDH C-domain-like [48187] (2 proteins)

4. a.100.1.4: UDP-glucose/GDP-mannose dehydrogenase dimerisation domain [48191] (2 proteins)

5. a.100.1.5: N-(1-D-carboxylethyl)-L-norvaline dehydrogenase [48194] (1 protein)

6. a.100.1.6: Glycerol-3-phosphate dehydrogenase [48197] (1 protein)

7. a.100.1.7: Ketopantoate reductase PanE [69084] (1 protein)

8. a.100.1.8: Conserved hypothetical protein MTH1747 [74762] (1 protein)

9. a.100.1.9: Mannitol 2-dehydrogenase [81843] (1 protein)

10. a.100.1.10: Pyrroline-5-carboxylate reductase ProC [116984] (1 protein)
    similar dimer to the class I KARI

11. a.100.1.11: HMD dimerization domain-like [140777] (1 protein)
    dimer similar to those of the GDP-mannose 6-dehydrogenase and class I KARI domains

12. a.100.1.12: TyrA dimerization domain-like [140780] (1 protein)
    new dimerisation mode with swapping of C-terminal helices

More info for Superfamily a.100.1: 6-phosphogluconate dehydrogenase C-terminal domain-like

Timeline for Superfamily a.100.1: 6-phosphogluconate dehydrogenase C-terminal domain-like:

• Superfamily a.100.1: 6-phosphogluconate dehydrogenase C-terminal domain-like first appeared (with stable ids) in SCOP 1.55
  
• Superfamily a.100.1: 6-phosphogluconate dehydrogenase C-terminal domain-like appears in SCOP 1.71
  
• Superfamily a.100.1: 6-phosphogluconate dehydrogenase C-terminal domain-like appears in SCOP 1.75
  
• Superfamily a.100.1: 6-phosphogluconate dehydrogenase C-terminal domain-like appears in the current release, SCOPe 2.08