SCOPe 2.06: Family a.39.1.7: EF-hand modules in multidomain proteins

Lineage for Family a.39.1.7: EF-hand modules in multidomain proteins

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.39: EF Hand-like [47472] (4 superfamilies)
   core: 4 helices; array of 2 hairpins, opened

4. Superfamily a.39.1: EF-hand [47473] (12 families)
   Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop

5. Family a.39.1.7: EF-hand modules in multidomain proteins [47547] (9 proteins)

Proteins:

1. alpha-Actinin [63553] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [63554] (1 PDB entry)

2. Cbl [47561] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [47562] (11 PDB entries)

3. Diacylglycerol kinase alpha, N-terminal domain [116905] (1 species)
   contains two pairs of EF-hands, the modified first pair (res 25-109) does not bind calcium but retains the common fold

   • Species Human (Homo sapiens) [TaxId:9606] [116906] (1 PDB entry)
     Uniprot O95217 P23743 1-116

4. DJ-1-binding protein, DJBP [140536] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [140537] (1 PDB entry)
     Uniprot Q5THR3 1160-1242

5. Dystrophin [47559] (1 species)
   probably lost calcium-binding function; contains extra helices in each domain

   • Species Human (Homo sapiens) [TaxId:9606] [47560] (2 PDB entries)

6. Nucleobindin 1 (CALNUC) [109825] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [109826] (1 PDB entry)
     Uniprot Q02818 228-326

7. Phosphoinositide-specific phospholipase C, isozyme D1 (PLC-D!) [47548] (1 species)

   • Species Norway rat (Rattus norvegicus) [TaxId:10116] [47549] (11 PDB entries)

8. Phospholipase C-beta-2 [158478] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [158479] (2 PDB entries)
     Uniprot Q00722 142-311

9. automated matches [190808] (1 species)
   not a true protein

   • Species Human (Homo sapiens) [TaxId:9606] [188079] (2 PDB entries)

More info for Family a.39.1.7: EF-hand modules in multidomain proteins

Timeline for Family a.39.1.7: EF-hand modules in multidomain proteins:

• Family a.39.1.7: EF-hand modules in multidomain proteins first appeared (with stable ids) in SCOP 1.55
  
• Family a.39.1.7: EF-hand modules in multidomain proteins appears in SCOPe 2.05
  
• Family a.39.1.7: EF-hand modules in multidomain proteins appears in SCOPe 2.07
  
• Family a.39.1.7: EF-hand modules in multidomain proteins appears in the current release, SCOPe 2.08