Lineage for Family a.39.1.5: Calmodulin-like

  1. Root: SCOP 1.65
  2. 275720Class a: All alpha proteins [46456] (179 folds)
  3. 280804Fold a.39: EF Hand-like [47472] (4 superfamilies)
    core: 4 helices; array of 2 hairpins, opened
  4. 280805Superfamily a.39.1: EF-hand [47473] (10 families) (S)
    Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop
  5. 280971Family a.39.1.5: Calmodulin-like [47502] (18 proteins)
    Duplication: made with two pairs of EF-hands

Proteins:

  1. 280972Calcineurin regulatory subunit (B-chain) [47530] (2 species)
    1. 280973Species Cow (Bos taurus) [TaxId:9913] [47531] (1 PDB entry)
    2. 280975Species Human (Homo sapiens) [TaxId:9606] [47532] (3 PDB entries)
  2. 280980Calcium vector protein [47514] (1 species)
  3. 280986Calcium- and integrin-binding protein, CIB [47541] (1 species)
  4. 280990Calcium-regulated photoprotein [47512] (3 species)
    structurally most similar to sarcoplasmic calcium-binding protein
    1. 280991Species Hydrozoa (Obelia geniculata), obelin [TaxId:185004] [63542] (1 PDB entry)
    2. 280993Species Hydrozoa (Obelia longissima), obelin [TaxId:32570] [63541] (2 PDB entries)
    3. 280996Species Jellyfish (Aequorea aequorea), aequorin [TaxId:168712] [47513] (1 PDB entry)
  5. 280999Calmodulin [47516] (9 species)
    1. 281000Species African frog (Xenopus laevis) [TaxId:8355] [47521] (10 PDB entries)
    2. 281011Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [89052] (3 PDB entries)
    3. 281015Species Chicken (Gallus gallus) [TaxId:9031] [47520] (1 PDB entry)
      mutant with a two residue deletion in the central helix
    4. 281017Species Ciliate (Paramecium tetraurelia) [TaxId:5888] [47523] (3 PDB entries)
    5. 281021Species Cow (Bos taurus) [TaxId:9913] [47518] (15 PDB entries)
    6. 281044Species Drosophila melanogaster [TaxId:7227] [47522] (4 PDB entries)
    7. 281050Species Human (Homo sapiens) [TaxId:9606] [47517] (6 PDB entries)
    8. 281063Species Nematode (Caenorhabditis elegans) [TaxId:6239] [89051] (1 PDB entry)
    9. 281065Species Rat (Rattus rattus) [TaxId:10117] [47519] (3 PDB entries)
  6. 281072Calmodulin-related protein NB-1 (CLP) [74721] (1 species)
  7. 281075Caltractin (centrin 2) [89053] (2 species)
    1. 281076Species Green algae (Chlamydomonas reinhardtii) [TaxId:3055] [89055] (1 PDB entry)
    2. 281078Species Human (Homo sapiens) [TaxId:9606] [89054] (1 PDB entry)
  8. 281080Cdc4p [63543] (1 species)
  9. 281083EHCABP [69021] (1 species)
  10. 281087Frequenin (neuronal calcium sensor 1) [47535] (2 species)
    1. 281088Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [47536] (1 PDB entry)
    2. 281090Species Human (Homo sapiens) [TaxId:9606] [63545] (1 PDB entry)
  11. 281093Guanylate cyclase activating protein 2, GCAP-2 [47537] (1 species)
  12. 281096Myosin Essential Chain [47524] (2 species)
    1. 281097Species Bay scallop (Aequipecten irradians) [TaxId:31199] [47525] (10 PDB entries)
    2. 281109Species Chicken (Gallus gallus) [TaxId:9031] [47526] (3 PDB entries)
  13. 281119Myosin Light Chain Mlc1p [81756] (1 species)
    light chain of class V myosin
  14. 281123Myosin Regulatory Chain [47527] (2 species)
    1. 281124Species Bay scallop (Aequipecten irradians) [TaxId:31199] [47528] (10 PDB entries)
    2. 281136Species Chicken (Gallus gallus) [TaxId:9031] [47529] (1 PDB entry)
  15. 281138Neurocalcin [47539] (1 species)
  16. 281142Recoverin [47533] (1 species)
    Calcium-myristoyl switch; only one EF-hand is functional
  17. 281148Sarcoplasmic calcium-binding protein [47509] (2 species)
    1. 281149Species Amphioxus (Branchiostoma lanceolatum) [TaxId:7740] [47511] (1 PDB entry)
    2. 281151Species Sandworm (Nereis diversicolor) [TaxId:126592] [47510] (1 PDB entry)
  18. 281154Troponin C [47503] (5 species)
    1. 281155Species Chicken (Gallus gallus) [TaxId:9031] [47504] (24 PDB entries)
    2. 281183Species Chicken (Gallus gallus), cardiac isoform [TaxId:9031] [47507] (1 PDB entry)
    3. 281185Species Human (Homo sapiens), cardiac isoform [TaxId:9606] [47508] (7 PDB entries)
    4. 281195Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [47506] (4 PDB entries)
    5. 281200Species Turkey (Meleagris gallopavo) [TaxId:9103] [47505] (2 PDB entries)

More info for Family a.39.1.5: Calmodulin-like

Timeline for Family a.39.1.5: Calmodulin-like: