Lineage for Protein: Calcyclin (S100)

  1. Root: SCOP 1.75
  2. 758332Class a: All alpha proteins [46456] (284 folds)
  3. 768455Fold a.39: EF Hand-like [47472] (4 superfamilies)
    core: 4 helices; array of 2 hairpins, opened
  4. 768456Superfamily a.39.1: EF-hand [47473] (11 families) (S)
    Duplication: consists of two EF-hand units: each is made of two helices connected with calcium-binding loop
  5. 768482Family a.39.1.2: S100 proteins [47478] (1 protein)
    dimer: subunits are made of two EF-hands
  6. 768483Protein Calcyclin (S100) [47479] (17 species)

Species:

  1. 768484Cow (Bos taurus), s100b [TaxId:9913] [47482] (6 PDB entries)
    1. Domains for 1cfp:
      1. 768491Domain d1cfpa_: 1cfp A: [17172]
      2. 768492Domain d1cfpb_: 1cfp B: [17173]
        mutant
    2. Domain for 1mho:
    3. Domains for 1psb:
      1. 768489Domain d1psba_: 1psb A: [95079]
        complexed with a peptide from Ndr kinase, chains C and D
      2. 768490Domain d1psbb_: 1psb B: [95080]
        complexed with a peptide from Ndr kinase, chains C and D
    4. Domain for 3cr2:
    5. Domain for 3cr4:
    6. Domain for 3cr5:
  2. 768493Human (Homo sapiens), calgranulin C, s100a12 [TaxId:9606] [47488] (3 PDB entries)
    1. Domains for 1e8a:
      1. 768494Domain d1e8aa_: 1e8a A: [17188]
      2. 768495Domain d1e8ab_: 1e8a B: [17189]
        complexed with ca
    2. Domains for 1gqm:
      1. 768502Domain d1gqma_: 1gqm A: [70360]
        structure in a hexameric form
      2. 768503Domain d1gqmb_: 1gqm B: [70361]
        structure in a hexameric form
      3. 768504Domain d1gqmc_: 1gqm C: [70362]
        structure in a hexameric form
      4. 768505Domain d1gqmd_: 1gqm D: [70363]
        structure in a hexameric form
      5. 768506Domain d1gqme_: 1gqm E: [70364]
        structure in a hexameric form
      6. 768507Domain d1gqmf_: 1gqm F: [70365]
        structure in a hexameric form
      7. 768508Domain d1gqmg_: 1gqm G: [70366]
        structure in a hexameric form
      8. 768509Domain d1gqmh_: 1gqm H: [70367]
        structure in a hexameric form
      9. 768510Domain d1gqmi_: 1gqm I: [70368]
        structure in a hexameric form
      10. 768511Domain d1gqmj_: 1gqm J: [70369]
        structure in a hexameric form
      11. 768512Domain d1gqmk_: 1gqm K: [70370]
        structure in a hexameric form
      12. 768513Domain d1gqml_: 1gqm L: [70371]
        structure in a hexameric form
        complexed with ca
    3. Domains for 1odb:
      1. 768496Domain d1odba_: 1odb A: [86840]
      2. 768497Domain d1odbb_: 1odb B: [86841]
      3. 768498Domain d1odbc_: 1odb C: [86842]
      4. 768499Domain d1odbd_: 1odb D: [86843]
      5. 768500Domain d1odbe_: 1odb E: [86844]
      6. 768501Domain d1odbf_: 1odb F: [86845]
        complexed with ca, cu
  3. 768514Human (Homo sapiens), calgranulin s100a8, MRP8 [TaxId:9606] [47487] (2 PDB entries)
    Migration inhibitory factor-related protein 8
    1. Domains for 1mr8:
      1. 768521Domain d1mr8a_: 1mr8 A: [17186]
      2. 768522Domain d1mr8b_: 1mr8 B: [17187]
        complexed with oc1
    2. Domains for 1xk4:
      1. 768515Domain d1xk4a1: 1xk4 A:1-87 [122055]
        complexed with ca, cl, flc; mutant
      2. 768516Domain d1xk4b1: 1xk4 B:1-87 [122056]
        automatically matched to 1XK4 A:1-87
        complexed with ca, cl, flc; mutant
      3. 768517Domain d1xk4e1: 1xk4 E:1-87 [122059]
        automatically matched to 1XK4 A:1-87
        complexed with ca, cl, flc; mutant
      4. 768518Domain d1xk4f1: 1xk4 F:1-87 [122060]
        automatically matched to 1XK4 A:1-87
        complexed with ca, cl, flc; mutant
      5. 768519Domain d1xk4i1: 1xk4 I:1-87 [122063]
        automatically matched to 1XK4 A:1-87
        complexed with ca, cl, flc; mutant
      6. 768520Domain d1xk4j1: 1xk4 J:1-87 [122064]
        automatically matched to 1XK4 A:1-87
        complexed with ca, cl, flc; mutant
  4. 768523Human (Homo sapiens), P11 s100a10, calpactin [TaxId:9606] [47484] (2 PDB entries)
    ligand of annexin II
    1. Domains for 1a4p:
      1. 768524Domain d1a4pa_: 1a4p A: [17176]
      2. 768525Domain d1a4pb_: 1a4p B: [17177]
    2. Domains for 1bt6:
      1. 768526Domain d1bt6a_: 1bt6 A: [17178]
      2. 768527Domain d1bt6b_: 1bt6 B: [17179]
        complexed with ace
  5. 768528Human (Homo sapiens), psoriasin s100a7 [TaxId:9606] [47485] (3 PDB entries)
    1. Domains for 1psr:
      1. 768529Domain d1psra_: 1psr A: [17180]
      2. 768530Domain d1psrb_: 1psr B: [17181]
        complexed with ho
    2. Domain for 2psr:
    3. Domains for 3psr:
      1. 768532Domain d3psra_: 3psr A: [17183]
      2. 768533Domain d3psrb_: 3psr B: [17184]
        complexed with ca, zn
  6. 768534Human (Homo sapiens), s100a13 [TaxId:9606] [140535] (4 PDB entries)
    Uniprot Q99584 1-98
    1. Domains for 1yur:
      1. 768539Domain d1yura1: 1yur A:1-98 [124062]
      2. 768540Domain d1yurb1: 1yur B:1-98 [124063]
        automatically matched to 1YUR A:1-98
    2. Domains for 1yus:
      1. 768541Domain d1yusa1: 1yus A:1-98 [124064]
        automatically matched to 1YUR A:1-98
      2. 768542Domain d1yusb1: 1yus B:1-98 [124065]
        automatically matched to 1YUR A:1-98
    3. Domains for 1yut:
      1. 768535Domain d1yuta1: 1yut A:1-98 [124066]
        automatically matched to 1YUR A:1-98
        complexed with ca
      2. 768536Domain d1yutb1: 1yut B:1-98 [124067]
        automatically matched to 1YUR A:1-98
        complexed with ca
    4. Domains for 1yuu:
      1. 768537Domain d1yuua1: 1yuu A:1-98 [124068]
        automatically matched to 1YUR A:1-98
        complexed with ca
      2. 768538Domain d1yuub1: 1yuu B:1-98 [124069]
        automatically matched to 1YUR A:1-98
        complexed with ca
  7. 768543Human (Homo sapiens), s100a3 [TaxId:9606] [74720] (1 PDB entry)
  8. 768546Human (Homo sapiens), s100a4 [TaxId:9606] [81754] (4 PDB entries)
    MTS1 protein
    1. Domains for 1m31:
      1. 768555Domain d1m31a_: 1m31 A: [78506]
      2. 768556Domain d1m31b_: 1m31 B: [78507]
    2. Domains for 2q91:
      1. 768551Domain d2q91a1: 2q91 A:2-97 [150135]
        automatically matched to d1m31a_
        complexed with ca
      2. 768552Domain d2q91b1: 2q91 B:2-97 [150136]
        automatically matched to d1m31a_
        complexed with ca
    3. Domains for 3c1v:
      1. 768547Domain d3c1va1: 3c1v A:2-94 [155867]
        automatically matched to d1m31a_
        complexed with ca
      2. 768548Domain d3c1vb1: 3c1v B:2-94 [155868]
        automatically matched to d1m31a_
        complexed with ca
      3. 768549Domain d3c1vc1: 3c1v C:2-94 [155869]
        automatically matched to d1m31a_
        complexed with ca
      4. 768550Domain d3c1vd1: 3c1v D:2-94 [155870]
        automatically matched to d1m31a_
        complexed with ca
    4. Domains for 3cga:
      1. 768553Domain d3cgaa1: 3cga A:4-90 [156615]
        automatically matched to d1m31a_
        complexed with ca
      2. 768554Domain d3cgab1: 3cga B:4-90 [156616]
        automatically matched to d1m31a_
        complexed with ca
  9. 768557Human (Homo sapiens), s100a6 [TaxId:9606] [74719] (4 PDB entries)
    1. Domain for 1k8u:
    2. Domain for 1k96:
    3. Domains for 1k9k:
      1. 768560Domain d1k9ka_: 1k9k A: [72206]
      2. 768561Domain d1k9kb_: 1k9k B: [72207]
        complexed with bme, ca
    4. Domain for 1k9p:
  10. 768563Human (Homo sapiens), s100a9 (mrp14) [TaxId:9606] [69020] (2 PDB entries)
    1. Domains for 1irj:
      1. 768570Domain d1irja_: 1irj A: [66289]
      2. 768571Domain d1irjb_: 1irj B: [66290]
      3. 768572Domain d1irjc_: 1irj C: [66291]
      4. 768573Domain d1irjd_: 1irj D: [66292]
      5. 768574Domain d1irje_: 1irj E: [66293]
      6. 768575Domain d1irjf_: 1irj F: [66294]
      7. 768576Domain d1irjg_: 1irj G: [66295]
      8. 768577Domain d1irjh_: 1irj H: [66296]
        complexed with ca, cps
    2. Domains for 1xk4:
      1. 768564Domain d1xk4c1: 1xk4 C:4-86 [122057]
        automatically matched to d1irja_
        complexed with ca, cl, flc; mutant
      2. 768565Domain d1xk4d1: 1xk4 D:4-86 [122058]
        automatically matched to d1irja_
        complexed with ca, cl, flc; mutant
      3. 768566Domain d1xk4g1: 1xk4 G:4-86 [122061]
        automatically matched to d1irja_
        complexed with ca, cl, flc; mutant
      4. 768567Domain d1xk4h1: 1xk4 H:4-86 [122062]
        automatically matched to d1irja_
        complexed with ca, cl, flc; mutant
      5. 768568Domain d1xk4k1: 1xk4 K:4-86 [122065]
        automatically matched to d1irja_
        complexed with ca, cl, flc; mutant
      6. 768569Domain d1xk4l1: 1xk4 L:4-86 [122066]
        automatically matched to d1irja_
        complexed with ca, cl, flc; mutant
  11. 768578Human (Homo sapiens), s100b [TaxId:9606] [47483] (4 PDB entries)
    1. Domains for 1mq1:
      1. 768589Domain d1mq1a_: 1mq1 A: [79392]
        complex with high-affinity target peptide trtk-12, chains C and D
      2. 768590Domain d1mq1b_: 1mq1 B: [79393]
        complex with high-affinity target peptide trtk-12, chains C and D
    2. Domains for 1uwo:
      1. 768591Domain d1uwoa_: 1uwo A: [17174]
      2. 768592Domain d1uwob_: 1uwo B: [17175]
    3. Domains for 2h61:
      1. 768579Domain d2h61a1: 2h61 A:1-90 [136169]
        automatically matched to d1mq1a_
        complexed with ca, pg4
      2. 768580Domain d2h61b1: 2h61 B:1-90 [136170]
        automatically matched to d1mq1a_
        complexed with ca, pg4
      3. 768581Domain d2h61c1: 2h61 C:1-90 [136171]
        automatically matched to d1mq1a_
        complexed with ca, pg4
      4. 768582Domain d2h61d1: 2h61 D:1-90 [136172]
        automatically matched to d1mq1a_
        complexed with ca, pg4
      5. 768583Domain d2h61e1: 2h61 E:1-90 [136173]
        automatically matched to d1mq1a_
        complexed with ca, pg4
      6. 768584Domain d2h61f1: 2h61 F:1-90 [136174]
        automatically matched to d1mq1a_
        complexed with ca, pg4
      7. 768585Domain d2h61g1: 2h61 G:1-90 [136175]
        automatically matched to d1mq1a_
        complexed with ca, pg4
      8. 768586Domain d2h61h1: 2h61 H:1-89 [136176]
        automatically matched to d1mq1a_
        complexed with ca, pg4
    4. Domains for 2pru:
      1. 768587Domain d2prua1: 2pru A:1-91 [149815]
        automatically matched to d1mq1a_
      2. 768588Domain d2prub1: 2pru B:1-91 [149816]
        automatically matched to d1mq1a_
  12. 768593Human (Homo sapiens), s100p [TaxId:9606] [81755] (2 PDB entries)
    1. Domain for 1j55:
    2. Domains for 1ozo:
      1. 768595Domain d1ozoa_: 1ozo A: [93851]
      2. 768596Domain d1ozob_: 1ozo B: [93852]
  13. 768597Pig (Sus scrofa), calgizzarin s100c (s100a11) [TaxId:9823] [47486] (1 PDB entry)
    • Domain for 1qls:
      • 768598Domain d1qlsa_: 1qls A: [17185]
        complex with annexin I N-terminus
        complexed with ace, ca
  14. 768599Rabbit (Oryctolagus cuniculus) [TaxId:9986] [47480] (5 PDB entries)
    1. Domains for 1a03:
      1. 768600Domain d1a03a_: 1a03 A: [17157]
      2. 768601Domain d1a03b_: 1a03 B: [17158]
    2. Domains for 1cnp:
      1. 768608Domain d1cnpa_: 1cnp A: [17161]
      2. 768609Domain d1cnpb_: 1cnp B: [17162]
    3. Domains for 1jwd:
      1. 768606Domain d1jwda_: 1jwd A: [71908]
      2. 768607Domain d1jwdb_: 1jwd B: [71909]
    4. Domains for 2cnp:
      1. 768602Domain d2cnpa_: 2cnp A: [17159]
      2. 768603Domain d2cnpb_: 2cnp B: [17160]
    5. Domains for 2jtt:
      1. 768604Domain d2jtta1: 2jtt A:1-90 [148205]
        automatically matched to d1a03a_
      2. 768605Domain d2jttb1: 2jtt B:1-90 [148206]
        automatically matched to d1a03a_
  15. 768610Rabbit (Oryctolagus cuniculus), calgizzarin s100a11 [TaxId:9986] [89047] (1 PDB entry)
  16. 768613Rat (Rattus norvegicus), s100a1 [TaxId:10116] [69019] (3 PDB entries)
    1. Domains for 1k2h:
      1. 768618Domain d1k2ha_: 1k2h A: [68056]
        apo-form
      2. 768619Domain d1k2hb_: 1k2h B: [68057]
        apo-form
    2. Domains for 1zfs:
      1. 768614Domain d1zfsa1: 1zfs A:1-93 [125003]
        automatically matched to d1k2ha_
        complexed with ca
      2. 768615Domain d1zfsb1: 1zfs B:1-93 [125004]
        automatically matched to d1k2ha_
        complexed with ca
    3. Domains for 2k2f:
      1. 768616Domain d2k2fa1: 2k2f A:1-93 [148258]
        automatically matched to d1k2ha_
        complexed with ca
      2. 768617Domain d2k2fb1: 2k2f B:1-93 [148259]
        automatically matched to d1k2ha_
        complexed with ca
  17. 768620Rat (Rattus norvegicus), s100b [TaxId:10116] [47481] (6 PDB entries)
    1. Domains for 1b4c:
      1. 768627Domain d1b4ca_: 1b4c A: [17169]
      2. 768628Domain d1b4cb_: 1b4c B: [17170]
    2. Domains for 1dt7:
      1. 768625Domain d1dt7a_: 1dt7 A: [17165]
        Other proteins in same PDB: d1dt7x_, d1dt7y_
        complex with the C-terminal negative regulatory domain of p53
      2. 768626Domain d1dt7b_: 1dt7 B: [17166]
        Other proteins in same PDB: d1dt7x_, d1dt7y_
        complex with the C-terminal negative regulatory domain of p53
        complexed with ca
    3. Domains for 1mwn:
      1. 768623Domain d1mwna_: 1mwn A: [79584]
        complex with high-affinity target peptide trtk-12, chains X and Y
      2. 768624Domain d1mwnb_: 1mwn B: [79585]
        complex with high-affinity target peptide trtk-12, chains X and Y
        complexed with ca
    4. Domains for 1qlk:
      1. 768621Domain d1qlka_: 1qlk A: [17163]
      2. 768622Domain d1qlkb_: 1qlk B: [17164]
        complexed with ca
    5. Domains for 1sym:
      1. 768631Domain d1syma_: 1sym A: [17167]
      2. 768632Domain d1symb_: 1sym B: [17168]
    6. Domains for 1xyd:
      1. 768629Domain d1xyda1: 1xyd A:0-91 [122457]
        automatically matched to d1b4ca_
        complexed with ca, zn
      2. 768630Domain d1xydb1: 1xyd B:0-91 [122458]
        automatically matched to d1b4ca_
        complexed with ca, zn

More info for Protein Calcyclin (S100) from a.39.1.2: S100 proteins

Timeline for Protein Calcyclin (S100) from a.39.1.2: S100 proteins: