SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Fold a.34: Dimerisation interlock

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 1993627Fold a.34: Dimerisation interlock [47405] (4 superfamilies)
    4 helices; bundle, closed, right-handed twist

Superfamilies:

  1. 1993628a.34.1: SinR repressor dimerisation domain-like [47406] (1 family) (S)
    intertwined heterodimer of two homologous chains
  2. 1993636a.34.2: Dimerization cofactor of HNF-1 alpha [100957] (1 family) (S)
    automatically mapped to Pfam PF04814
  3. 1993656a.34.3: Docking domain A of the erythromycin polyketide synthase (DEBS) [101166] (1 family) (S)
    automatically mapped to Pfam PF09277
  4. 1993662a.34.4: Phenylalanine zipper [109805] (1 family) (S)
    interlocking dimer with longer helices and aromatic-rich core
    automatically mapped to Pfam PF08916

More info for Fold a.34: Dimerisation interlock

Timeline for Fold a.34: Dimerisation interlock: